Cholesterol metabolism in tumor immunity: Mechanisms and therapeutic opportunities for cancer

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116802 - 116802

Опубликована: Фев. 1, 2025

Язык: Английский

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Virulence factors and therapeutic methods of Trueperella pyogenes : A review

Virulence, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 21, 2025

Trueperella pyogenes is a prevalent opportunistic pathogen responsible for wide range of infections in livestock and wildlife, such as cattle, pigs, European bison forest musk deer. Much the successful infection T. relies on its virulence factors, including pyolysin well adhesion factors. The swift rise bacterial resistance has highlighted urgent need developing new therapeutic strategies. Currently, factor-mediated vaccine development other approaches are widely regarded primary interventions addressing diseases associated with this pathogen. This review examines broader potential pyogenes, focusing haemolysin, host cell proteins, prevalence antibiotic resistance, vaccines mediated by Additionally, it discusses current future aimed at improving interventions.

Язык: Английский

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Hypoxia- and Lactate Metabolism-Associated Prognostic and Therapeutic Signature in Pancreatic Cancer

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Background: Hypoxia and lactate metabolism products are critical components of the tumor microenvironment in pancreatic cancer (PC), influencing invasiveness, metastasis, treatment resistance. This study aims to explore role hypoxia- metabolism-related genes (HLRGs) predicting overall survival guiding for PC patients. Methods: Gene expression clinical data from patients were obtained TCGA, ICGC, GEO. Normal tissue sourced GTEx. Differential analysis was performed on merged TCGA-PAAD GTEx cohorts identify differentially expressed (DEGs). We an intersection between DEGs HLRGs MsigDB database associated with hypoxia PC. A prognostic model developed using random forests, Cox regression, LASSO cohort. The externally validated ICGC-PACA GSE85916 cohorts. Risk stratification performed, differences subgroups mutational burden, immune microenvironment, drug response analyzed. RT-qPCR key differences. Results: A based (SLC7A7, PYGL, HS3ST1, DDIT4, CYP27A1, ANKZF1, COL5A1) established. High-risk exhibited worse prognosis, higher better anti-PD-L1 therapy, while low-risk infiltration increased chemotherapy sensitivity. confirmed that SLC7A7 COL5A1 upregulated, ANKZF1 downregulated Conclusions: We HLRGs-based predicts guides strategies, contributing precision therapy

Язык: Английский

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Integrating Gene Demethylation and Immune Modulation: PD-1 Nanovesicles as a Dual-Action Therapy for NSCLC

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101851 - 101851

Опубликована: Май 1, 2025

Язык: Английский

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11th ENOR meeting: Oxysterols in human health and diseases

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2024, Номер 239, С. 106495 - 106495

Опубликована: Фев. 27, 2024

Язык: Английский

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