Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19 DOI Creative Commons

Huirong Dai,

Chih‐Jung Chang, Zishun Li

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 11, 2025

Background Multiple lines of evidence indicate a connection between the pathogenesis coronavirus disease 2019 (COVID-19) and psychiatric diseases (PDs). To improve treatment management individuals with psychosis COVID-19, we evaluated biomarkers PD patients, including those schizophrenia (SCZ), bipolar disorder (BD), major depression (MDD), along COVID-19. Methods In this study, 104 inpatients concurrent COVID-19 (PD+), same patients after they had recovered from (PD-), 97 healthy controls (HCs) were evaluated. We analyzed peripheral blood hematological parameters, serum biochemical cytokine levels participants compared results among three groups. Results The monocyte count; neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte (MLR); systemic immune-inflammation index (SII); C-reactive protein (CRP), CK isoenzyme MB (CK-MB), glucose (GLU), interleukin (IL)-6 significantly greater ( P < 0.05), whereas magnesium (Mg) level was lower 0.05) in both PD+ PD- groups than HC group. Moreover, above indicators different 0.05). Conclusion Neutrophil count, NLR, MLR, SII, CRP, CK-MB, GLU IL-6 positively correlated PD. Mg negatively Our findings suggest that supplementation might be considered potential approach for Despite these insights, underlying pathophysiological mechanisms remain unclear, highlighting vital need further research to validate build upon findings.

Язык: Английский

Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19 DOI Creative Commons

Huirong Dai,

Chih‐Jung Chang, Zishun Li

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 11, 2025

Background Multiple lines of evidence indicate a connection between the pathogenesis coronavirus disease 2019 (COVID-19) and psychiatric diseases (PDs). To improve treatment management individuals with psychosis COVID-19, we evaluated biomarkers PD patients, including those schizophrenia (SCZ), bipolar disorder (BD), major depression (MDD), along COVID-19. Methods In this study, 104 inpatients concurrent COVID-19 (PD+), same patients after they had recovered from (PD-), 97 healthy controls (HCs) were evaluated. We analyzed peripheral blood hematological parameters, serum biochemical cytokine levels participants compared results among three groups. Results The monocyte count; neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte (MLR); systemic immune-inflammation index (SII); C-reactive protein (CRP), CK isoenzyme MB (CK-MB), glucose (GLU), interleukin (IL)-6 significantly greater ( P < 0.05), whereas magnesium (Mg) level was lower 0.05) in both PD+ PD- groups than HC group. Moreover, above indicators different 0.05). Conclusion Neutrophil count, NLR, MLR, SII, CRP, CK-MB, GLU IL-6 positively correlated PD. Mg negatively Our findings suggest that supplementation might be considered potential approach for Despite these insights, underlying pathophysiological mechanisms remain unclear, highlighting vital need further research to validate build upon findings.

Язык: Английский

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