Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model
Journal of Magnetic Resonance Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Background
As
ferroptosis
is
a
key
factor
in
renal
fibrosis
(RF),
iron
deposition
monitoring
may
help
evaluating
RF.
The
capability
of
quantitative
susceptibility
mapping
(QSM)
for
detecting
RF
remains
uncertain.
Purpose
To
investigate
the
potential
QSM
to
detect
Study
Type
Animal
model.
Model
Eighty
New
Zealand
rabbits
were
randomly
divided
into
control
(N
=
10)
and
70)
groups,
consisting
baseline,
7,
14,
21,
28
days
12
each),
longitudinal
subgroups.
was
induced
via
unilateral
arteria
stenosis.
Field
Strength/Sequence
3
T,
with
gradient
echo,
arterial
spin
labeling
echo.
Assessment
Bilateral
kidney
values
(
χ
)
cortex
CO
outer
medulla
OM
evaluated
histopathology.
Statistical
Tests
Analysis
variance,
Kruskal–Wallis,
Spearman's
correlation,
area
under
receiver
operating
characteristic
curve
(AUC).
P
<
0.05
significant.
Results
In
fibrotic
kidneys,
decreased
at
7
([−6.69
±
0.98]
×
10
−2
ppm)
increased
during
14–28
([−1.85
2.11],
[0.14
0.58],
[1.99
0.60]
ppm,
respectively),
while
had
opposite
trend.
Both
significantly
correlated
histopathology
(|
r
|
0.674–0.849).
AUC
distinguishing
degrees
0.692–0.993.
contralateral
initially
([−6.67
0.84]
then
recovered
baseline
([−4.81
0.89]
ppm),
7–28
([2.58
1.40],
[2.25
1.83],
[2.49
[2.43
1.32]
respectively)
higher
than
([0.54
0.18]
ppm).
Data
Conclusion
Different
patterns
observed
values,
suggesting
Plain
Language
Summary
Renal
(RF)
common
outcome
most
diseases,
leading
scarring
loss
function.
Increasing
evidence
suggests
that
abnormal
metabolism
plays
an
important
role
This
study
used
technique
called
measure
levels
Specifically,
advanced
exhibited
concentrations,
moderate
strong
correlations
between
demonstrated
could
accurately
changes
assess
severity.
Overall,
shows
promise
as
tool
progression.
Evidence
Level
2
Technical
Efficacy
Stage
Язык: Английский
Serum Soluble Asialoglycoprotein Receptor 1: A Potential Predictor Marker Linked to Type 2 Diabetes Mellitus, Demonstrating Positive Correlation With High Sensitive C-Reactive Protein
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2025,
Номер
Volume 18, С. 663 - 675
Опубликована: Фев. 1, 2025
Asialoglycoprotein
receptor
1
(ASGR1)
deficiency
has
been
implicated
in
enhancing
liver
insulin
sensitivity
and
reducing
systemic
resistance,
thus
highlighting
its
pivotal
role
glucose
metabolism.
However,
the
association
between
serum
soluble
asialoglycoprotein
(sASGR1)
type
2
diabetes
mellitus
(T2DM)
remains
elusive.
Therefore,
we
conducted
a
study
to
delve
into
this
association.
From
July
October
2024,
220
newly
diagnosed
T2DM
patients
an
equal
number
of
matched
controls
with
normal
tolerance
(NGT)
were
enrolled.
Serum
sASGR1
levels
quantified
using
ELISA,
carotid
artery
assessed
ultrasound
imaging.
The
median
level
was
significantly
higher
group
(6.58
ng/mL)
compared
NGT
(5.26
ng/mL).
Notably,
no
significant
difference
observed
individuals
without
atherosclerosis
or
fatty
liver.
In
group,
exhibited
positive
correlation
high-sensitivity
C-reactive
protein
(hs-CRP)
interleukin-6
(IL-6).
Among
patients,
positively
associated
estimated
glomerular
filtration
rate
(eGFR),
resistance
(as
measured
by
HOMA-IR),
triglycerides
(TG),
hs-CRP,
but
negatively
creatinine
(Cr).
linear
regression
analysis
identified
Cr
as
independent
negative
factor
hs-CRP
levels.
Logistic
indicated
that
highest
had
odds
developing
lowest
even
after
adjusting
for
potential
confounders.
significance
attenuated
further
adjustment
hs-CRP.
area
under
receiver
operating
characteristic
(ROC)
curve
0.610.
are
elevated
correlate
demonstrates
limited
predictive
value
onset
T2DM.
Further
research
is
warranted
explore
renal
function,
blood
lipids,
health,
arteriosclerosis.
Язык: Английский
Managing Dyslipidemia in Chronic Kidney Disease: Implications for Cardiovascular and Renal Risk
Current Atherosclerosis Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Март 21, 2025
Язык: Английский
Inflammatory markers mediate association of AIP with kidney failure risk: data from National Health and Nutrition Examination Survey (NHANES) 2005–2018
Renal Failure,
Год журнала:
2025,
Номер
47(1)
Опубликована: Апрель 15, 2025
Dyslipidemia
and
inflammation
often
coexist
in
the
progression
of
kidney
failure,
with
atherosclerosis
index
plasma
(AIP)
serving
as
a
valuable
marker
for
monitoring
dyslipidemia.
This
cross-sectional
study
analyzed
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2005
to
2018,
involving
total
10,358
participants.
AIP
was
calculated
logarithmic
ratio
(base
10)
triglycerides
high-density
lipoprotein
cholesterol
(log10[TG/HDL-C]),
while
failure
assessed
through
self-reported
physician
diagnosis.
Logistic
regression
models
restricted
cubic
splines
(RCS)
were
utilized
examine
association
between
risk
additional
subgroup
analyses
performed
explore
potential
interactions.
Mediation
conducted
investigate
whether
inflammatory
markers
mediated
relationship
failure.
In
logistic
regression,
after
adjusting
all
covariates,
found
be
positively
associated
[OR
=
1.74
(95%
CI:
1.04-2.92)],
linear
observed
(P-non-linear
0.4050).
analysis
revealed
that
segmented
neutrophils,
eosinophils,
monocytes
partially
mediation
proportions
19.65%,
2.44%,
7.25%,
respectively.
These
findings
suggest
Higher
an
increased
partial
mediators.
The
results
provide
insights
into
role
highlight
avenues
its
prevention.
Язык: Английский
Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study
Journal of Clinical Hypertension,
Год журнала:
2024,
Номер
27(1)
Опубликована: Ноя. 16, 2024
Circulating
lipids
play
a
crucial
role
during
pregnancy
and
may
impact
various
pregnancy-related
diseases.
This
study
employed
two-sample
Mendelian
randomization
(MR)
framework
to
investigate
the
causal
relationship
between
alterations
in
multidimensional
plasma
lipid
levels
risk
of
preeclampsia
or
eclampsia,
offering
deeper
insight
into
this
association.
The
inverse
variance
weighted
(IVW)
method
was
utilized
as
main
analysis.
Summary
statistics
from
lipidomics
7174
Finnish
individuals
summary
data
on
preeclampsia/eclampsia
FinnGen
consortium
involving
219
817
European
participants
were
employed.
Sensitivity
analyses
conducted
evaluate
heterogeneity
pleiotropy.
identified
17
species
total
179
associated
with
susceptibility
preeclampsia/eclampsia.
Notably,
ten
species,
including
six
triacylglycerols
(TAGs)
(50:1,
48:1,
56:4,
49:2,
48:2,
54:3),
diacylglycerol
(DAG)
(16:1_18:1),
three
sphingomyelins
(SMs)
(d36:1,
d34:1,
d38:1),
found
increase
Conversely,
seven
five
phosphatidylcholines
(PCs)
(16:1_20:4,
O-18:1_20:4,
18:1_20:4,
16:0_20:4,
17:0_20:4)
two
phosphatidylethanolamines
(PEAs)
(18:0_20:4,
16:0_20:4),
all
containing
arachidonic
acid
(ARA)
sn-2
position,
reduced
(all
p
<
0.05).
results
stratified
analysis
consistent
these
findings.
Furthermore,
reverse
MR
indicated
that
does
not
causally
affect
lipids.
Our
findings
established
specific
modulation
risk,
providing
improved
resolution
for
assessment
potential
therapeutic
targets
disease.
Язык: Английский