Effect of Sterilization Methods on the Morphological, Molecular, and Biocompatibility Characteristics of Nanofibrous PEEK Layers

E3S Web of Conferences, Год журнала: 2024, Номер 588, С. 01001 - 01001

Опубликована: Янв. 1, 2024

In this work, the polyether ether ketone (PEEK) nanofibrous layers and their sterilized methods influence on molecular properties, structural biocompatibility have been discussed.Some instrument employed were gamma radiation, ultraviolet light, Ethylene oxide (EtOx) an autoclave to sterilised developed through melt-electrospinning process.umber of instruments used such as ethylene (EtOx), was sterilise prepared via process. The SEM result unveiled that sterilization processes changed fibre form slightly well diameter which modified well.However, did not alter weight PEEK fibers, far GPC study concerned.d has explored. A number scanning electron microscopy (SEM) showed altered fiber’s along with small variations in diameter. While, achanged according gel permeation chromatography (GPC) research. addition, murine fibroblasts (3T3) assessed for vitro using MTT test. While cell adhesion proliferation rate same across all sterile control sample, UV-sterilized material significantly reduced level viability. Consequently, methods, namely autoclave, EtOx, radiation determined be efficient layers. However, solar method may also reduce biocompatibility.

Язык: Английский

Functional Mechanical Behavior and Biocompatible Characteristics of Graphene-Coated Cardiovascular Stents

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13345 - 13345

Опубликована: Дек. 12, 2024

Percutaneous Coronary Intervention (PCI) is a treatment method that involves reopening narrowed arteries with balloon catheter delivers cylindrical, mesh-shaped implant device to the site of stenosis. Currently, by applying coating bare metal stent (BMS) surface improve biocompatibility, main risks after PCI, such as restenosis and thrombosis, are reduced while maintaining basic requirements for mechanical behavior itself. In this work, first time, development optimization process spatial structure Co-Cr (L-605) graphene-based using cold-wall chemical vapor deposition (CW-CVD) ensure uniform coverage was attempted. The CW-CVD allows 3D structures, minimizing thermal stress on surrounding equipment allowing coatings temperature-sensitive materials. It produces high-purity films control over thickness composition. heating chamber walls minimizes unwanted reactions, leading fewer impurities in final coating. graphene layers obtained Raman spectroscopy at different parameters were verified, their properties investigated, functional studied graphene-covered confirmed. vitro, graphene-coated stents promoted rapid endothelial cell repopulation, an advantage gold-standard drug-eluting delaying re-endothelialization. Also, full-range biocompatibility studies potential allergic, irritation, toxicological, pyrogenic reactions new material vivo small animal models demonstrated excellent stents.

Язык: Английский

Covalent conjugate based on graphene oxide and alkylating agent belonging to 1,3,5-triazine class as promising agent for anticancer chemo- and phototherapy

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141046 - 141046

Опубликована: Дек. 1, 2024

Язык: Английский