Modern biology of extrachromosomal DNA: A decade-long voyage of discovery

Cell Research, Год журнала: 2025, Номер 35(1), С. 11 - 22

Опубликована: Янв. 3, 2025

Abstract Genomic instability is a hallmark of cancer and major driving force tumorigenesis. A key manifestation genomic the formation extrachromosomal DNAs (ecDNAs) — acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, distinct chromosomes. Ontological studies have revealed that ecDNA serves as carrier oncogenes, immunoregulatory genes, enhancers, capable elevated transcription its cargo genes heterogeneity, leading rapid tumor evolution therapy resistance. Although was documented over half century ago, past decade has witnessed surge breakthrough discoveries about biological functions. Here, we systematically review modern biology uncovered last ten years, focusing on how during this pioneering stage illuminated our understanding ecDNA-driven transcription, progression. Furthermore, discuss ongoing efforts target novel approach therapy. This burgeoning field entering new phase, poised reshape knowledge therapeutic strategies.

Язык: Английский

Advanced Techniques for the Analysis of Proteins and RNAs

Chemosensors, Год журнала: 2024, Номер 12(1), С. 12 - 12

Опубликована: Янв. 10, 2024

Proteins and RNAs, as fundamental components of cellular machinery, play pivotal roles in the intricate landscape life [...]

Язык: Английский