Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review

Nanomaterials, Год журнала: 2020, Номер 10(6), С. 1244 - 1244

Опубликована: Июнь 26, 2020

The propose of this review was to summarize the advances in multi-scale surface technology titanium implants accelerate osseointegration process. several multi-scaled methods used for improving wettability, roughness, and bioactivity implant surfaces are reviewed. In addition, macro-scale (e.g., 3D printing (3DP) laser texturing (LST)), micro-scale grit-blasting, acid-etching, Sand-blasted, Large-grit, Acid-etching (SLA)) nano-scale plasma-spraying anodization) also discussed, these known have favorable properties clinical applications. Functionalized coatings with organic non-organic loadings suggest good prospects future modern biotechnology. Nevertheless, because high cost low validation, partial not been commercially available so far. A large number vitro vivo investigations necessary order obtain in-depth exploration about efficiency functional surfaces. prospective should possess optimum chemistry, bionic characteristics, standardized topographies achieve rapid osseointegration.

Язык: Английский

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Recent advances in Ti-6Al-4V additively manufactured by selective laser melting for biomedical implants: Prospect development

Journal of Alloys and Compounds, Год журнала: 2021, Номер 896, С. 163072 - 163072

Опубликована: Дек. 3, 2021

Язык: Английский

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Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo

Bioengineering & Translational Medicine, Год журнала: 2021, Номер 7(1)

Опубликована: Июнь 27, 2021

Titanium is commonly and successfully used in dental orthopedic implants. However, patients still have to face the risk of implant failure due various reasons, such as loosening or infection. The can be countered by optimizing osteointegration capacity materials. Implant surface modifications for structuring, roughening biological activation favor osteogenic differentiation been vastly studied. A key factor a successful stable long-term integration initial cellular response material. Hence, cell-material interactions, which are dependent on parameters, need considered design. Therefore, this review starts with an introduction basics interactions well common modification techniques. Afterwards, recent research impact processes vitro vivo provoked reviewed discussed, order give update currently applied developing techniques enhancing osteointegration.

Язык: Английский

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Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Frontiers in Bioengineering and Biotechnology, Год журнала: 2021, Номер 9

Опубликована: Март 26, 2021

Design an implant similar to the human bone is one of critical problems in tissue engineering. Metal porous scaffolds have good prospects replacement due their matching elastic modulus, better strength, and biocompatibility. However, traditional processing methods are challenging fabricate with a structure, limiting development scaffolds. With advancement additive manufacturing (AM) computer-aided technologies, metal also ushers unprecedented opportunities. In recent years, many new materials innovative design used excellent mechanical properties This article reviews research progress scaffolds, introduces AM technologies Then applications different summarized, advantages limitations various scaffold discussed. Finally, we look forward

Язык: Английский

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Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare

Progress in Materials Science, Год журнала: 2023, Номер 134, С. 101072 - 101072

Опубликована: Янв. 16, 2023

Язык: Английский

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Design of a biomimetic graded TPMS scaffold with quantitatively adjustable pore size

Materials & Design, Год журнала: 2022, Номер 218, С. 110665 - 110665

Опубликована: Апрель 20, 2022

The advantages of "printing the right material in position" and unique structure for function" additive manufacturing make design biomimetic graded scaffold bone tissue engineering possible. Here, under different porosities, we propose a TPMS with adjustable pore size, providing guidance designing porous implants without characteristics stress concentration, shielding barrier mass transport. Specifically, structural can be achieved concentration. By adjusting porosity, elastic modulus Ti6Al4V samples adjusted range 1158–4567 MPa, which match individual selection mechanical properties biological bone. Since is designed by layer-by-layer splicing, through height parameters single-layer structure, selective size variation realized to further transport Then, vitro culture experiments have been conducted maximum cell survival rate an offset constant 0.4 85.44%, meet implants. As such, proposed this paper shows excellent potential orthopedic

Язык: Английский

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The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(7), С. 341 - 341

Опубликована: Июнь 27, 2023

The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters, including the patient’s age, comorbidities, systemic disorders, anatomical location defect, surgeon’s preference experience. most used therapeutic modalities for regeneration long include distraction osteogenesis (bone transport), free vascularized fibular grafts, Masquelet technique, allograft, (arthroplasty with) mega-prostheses. Over past 25 years, three-dimensional (3D) printing, breakthrough layer-by-layer manufacturing technology that produces final parts directly from 3D model data, has taken off transformed enabling personalized therapies highly porous 3D-printed implants tailored to patient. Therefore, reduce morbidities complications associated current regimens, efforts have been made in translational research toward scaffolds facilitate regeneration. Three-dimensional printed should not only provide osteoconductive surfaces cell attachment subsequent formation also physical support containment graft material during process, enhancing ingrowth, while simultaneously, orthopaedic supply mechanical strength rigid, stable external and/or internal fixation. In this perspective review, we focus on elaborating history defect methods assessing approaches as well recent developments, existing evidence advantages disadvantages Furthermore, it is evident regulatory framework organization financing evidence-based trials very complex, new challenges non-biodegradable biodegradable emerging yet sufficiently addressed, such guideline development specific surgical indications, clinically feasible design concepts needed multicentre international preclinical trials, medico-legal status, reimbursement. These underscore need intensive exchange open honest debate among leaders field. This goal addressed well-planned focused stakeholder workshop topic patient-specific regeneration, proposed review.

Язык: Английский

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Additively Manufactured Porous Ti6Al4V for Bone Implants: A Review

Metals, Год журнала: 2022, Номер 12(4), С. 687 - 687

Опубликована: Апрель 16, 2022

Ti-6Al-4V (Ti64) alloy is one of the most widely used orthopedic implant materials due to its mechanical properties, corrosion resistance, and biocompatibility nature. Porous Ti64 structures are gaining more research interest as bone implants they can help in reducing stress-shielding effect when compared their solid counterpart. The literature shows that porous fabricated using different additive manufacturing (AM) process routes, such laser powder bed fusion (L-PBF) electron beam melting (EBM) be tailored mimic properties natural bone. This review paper categorizes designs into non-gradient (uniform) gradient (non-uniform) structures. Gradient design appears promising for applications closeness towards morphology improved properties. In addition, this outlines details on structure fatigue behavior, multifunctional designs, current challenges, gaps studies implants.

Язык: Английский

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3D-printed PEEK implant for mandibular defects repair - a new method

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2021, Номер 116, С. 104335 - 104335

Опубликована: Янв. 22, 2021

Язык: Английский

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Development of AM Technologies for Metals in the Sector of Medical Implants

Metals, Год журнала: 2020, Номер 10(5), С. 686 - 686

Опубликована: Май 23, 2020

Additive manufacturing (AM) processes have undergone significant progress in recent years, having been implemented sectors as diverse automotive, aerospace, electrical component manufacturing, etc. In the medical sector, different devices are printed, such implants, surgical guides, scaffolds, tissue engineering, Although nowadays some implants made of plastics or ceramics, metals traditionally employed their manufacture. However, metallic obtained by traditional methods machining drawbacks that they manufactured standard sizes, and it is difficult to obtain porous structures favor fixation prostheses means osseointegration. The present paper presents an overview use AM technologies manufacture implants. First, used for presented, focusing on main advantages each one them. Considered binder jetting (BJ), selective laser melting (SLM), electron beam (EBM), direct energy deposition (DED), material extrusion fused filament fabrication (FFF) with metal filled polymers. Then, sector listed, properties summarized, focus Ti CoCr alloys. They divided into two groups, namely ferrous non-ferrous Finally, state-of-art about summarized. will help explain latest application

Язык: Английский

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