Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Curcumin
(cur)
possesses
excellent
therapeutic
properties,
including
anti-inflammatory,
antioxidant,
and
healing-promoting
effects.
However,
its
biomedical
application
is
impeded
by
rapid
degradation,
limited
bioavailability,
poor
aqueous
solubility.
Zeolitic
imidazole
framework
(ZIF-8),
with
a
high
surface
area
tunable
pore
size,
designed
used
as
cur
delivery
carrier
to
overcome
these
limitations.
The
synthesis
of
cur-loaded
ZIF-8
involves
solvothermal
method,
followed
encapsulation
within
the
porous
structure
ZIF-8.
amount
was
varied
synthesize
series
panel
0.5
mg/mL
cur@ZIF-8
that
showed
higher
drug
loading
efficiency
(85.91
±
1.26%)
capability
(12.93
0.19%)
without
changes
in
shape,
crystallinity,
chemical
composition,
thermal
stability
original
exhibited
(1591.02
m2/g)
micropore
volume
(0.54
cm3/g).
Cur@ZIF-8
demonstrated
superior
outstanding
antibacterial
achieving
99%
compared
free
cur.
It
less
cytotoxicity
against
human
fibroblast
cells
better
antioxidant
properties
than
Furthermore,
release
rate
under
acidic
conditions,
which
promotes
wound
healing
due
microenvironment
skin.
biocompatibility
nanoparticles
highlight
their
potential
promising
candidates
for
diverse
applications.
Язык: Английский
Biowaste Transformation to Functional Materials: Structural Properties, Extraction Methods, Applications, and Challenges of Silk Sericin
Mohashin Kabir,
Mohammed Kamrul Hasan,
Mohamad Rafi
и другие.
ChemistrySelect,
Год журнала:
2024,
Номер
9(42)
Опубликована: Ноя. 1, 2024
Abstract
This
review
underscores
the
novelty
of
silk
sericin,
often
regarded
as
a
byproduct
in
production.
Comprising
approximately
30%
silk,
sericin
possesses
valuable
properties
that
have
been
largely
overlooked
favor
fibroin.
work
focuses
on
innovative
extraction
methods
to
convert
typically
considered
waste,
into
resource.
By
examining
these
techniques
alongside
diverse
applications,
aims
enhance
recognition
and
utilization
research
industry.
Various
processes
where
traditional
methods,
some
new
techniques,
are
all
discussed.
In
detail,
advantages,
limitations,
strategy
optimization
associated
with
each
method
highlighted.
For
instance,
has
shown
promise
wound
treatment
agent,
scaffold
for
tissue
engineering,
carrier
drug
delivery,
biomaterial
regenerative
medicine
field
biomedical
science
due
its
biocompatibility,
biodegradability,
nontoxicity.
Additionally,
it
also
finds
application
cosmetic
industry,
is
used
skincare
products
moisturizing,
antioxidant,
antiaging
properties.
Eventually,
challenges,
prospects
intensively
comprehensive
expected
serve
growing
body
knowledge
surrounding
foster
further
development
sericin‐related
fields.
Язык: Английский
Lumbrokinase-containing gelatin nanofibers with multiple bioactivities for effective skin wound healing
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101713 - 101713
Опубликована: Март 30, 2025
Wound
healing
is
a
highly
complex
and
intricate
biological
process
involving
cellular
molecular
events.
Given
that
lumbrokinase
fibrinolytic
enzyme
derived
from
earthworms
exhibits
notable
anti-inflammatory,
anti-fibrotic,
pro-angiogenic
functions,
this
study
aims
to
investigate
the
development
of
bioactive
gelatin
nanofibers
containing
(GLK)
fabricated
through
electrospinning
as
novel
nanomedicine
strategy
for
enhancing
wound
healing.
Our
results
showed
reducing
time
can
increase
cross-linking
degree
decrease
degradation
rate
maintain
an
effective
concentration
released
LK
supporting
long-term
processes.
Cells
cultured
with
biocompatible
GLK
displayed
good
adhesion
extensive
spreading,
increased
VEGF
production,
lowered
IL-6
TNF-α
secretion.
The
superior
multiple
bioactivities
was
further
tested
tissue
regeneration
potential
in
rat
model
skin
defect.
treatment
animals
shortens
time,
reduces
damage
caused
by
inflammation,
increases
collagen
angiogenesis,
fibroblast
proliferation/epithelialization,
demonstrating
effect
on
local
wounds
comparable
Comfeel
group.
Overall,
findings
preclinical
studies
suggest
high
promise
LK-loaded
biopolymer
dressing
materials
promoting
regenerative
environment
accelerating
healing,
indicating
its
future
translational
potential.
Язык: Английский
Tri-layer gradient fibre-aligned electrospun composite: Accelerating skin wound healing
Materials Today Communications,
Год журнала:
2025,
Номер
45, С. 112320 - 112320
Опубликована: Апрель 1, 2025
Язык: Английский
Tannic acid-etched PAN/PVP nanofibers loaded with Cu-MOFs enhance antibacterial efficacy and accelerate wound healing
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
253, С. 114719 - 114719
Опубликована: Апрель 18, 2025
Язык: Английский
Recent advances of HKUST-1 metal–organic frameworks in the biomedical applications: A comprehensive review
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162753 - 162753
Опубликована: Апрель 1, 2025
Язык: Английский
A Novel Bilayer Hydrogel/ Fibrous Wound Dressing Comprising Falcaria vulgaris Extract and Green Synthesized ZnO Nanoparticles Accelerates Wound Healing Process
Journal of Science Advanced Materials and Devices,
Год журнала:
2025,
Номер
unknown, С. 100896 - 100896
Опубликована: Апрель 1, 2025
Язык: Английский