European Polymer Journal,
Год журнала:
2024,
Номер
215, С. 113251 - 113251
Опубликована: Июнь 19, 2024
Meeting
the
escalating
demands
in
biomedical
applications
has
spurred
creation
of
diverse
scaffolds,
where
selection
materials
and
manufacturing
techniques
stands
as
a
linchpin
fostering
bone
tissue
formation.
These
scaffolds
provide
fundamental
structural
framework
that
supports
cell
growth
differentiation.
It
is
vital
for
repair,
addressing
various
biological
requisites
such
biocompatibility,
biodegradability,
mechanical
properties
becomes
imperative.
This
comprehensive
review
discusses
recent
advancements
3D
tailored
specifically
engineering
applications.
Stereolithography,
fused
deposition
modelling,
selective
laser
sintering,
binder
jetting,
electron
beam
melting,
bioprinting
(including
laser-based,
inkjet
extrusion
bioprinting)
are
meticulously
explored.
Focusing
on
their
respective
applications,
limitations,
well
advantages
disadvantages
within
context
regeneration.
Furthermore,
article
underscores
pivotal
role
material
potential
solution
to
address
challenges
associated
with
grafts.
emphasizes
need
nuanced
understanding
significant
considerations
regardless
type
when
designing
or
evaluating
suitability
integration
into
expansive
realm
engineering.
Advanced Engineering Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 8, 2024
This
study
is
initiated
with
the
aim
of
regulating
release
silver
(Ag)
as
an
antibacterial
agent
from
micro‐arc
oxidation
(MAO)
coating.
Herein,
external
5
wt%
Tin(II)
chloride
(SnCl
2
)
containing
biodegradable
polycaprolactone
(PCL)
layer
formed
on
0.8
Ag‐incorporated
MAO
coating
by
dip
method.
SnCl
addition
into
PCL
provides
a
steady
Ag
concentrated
simulated
body
fluid
(1.5X
SBF)
underlying
at
37
°C.
When
rate
taken
consideration,
it
quantified
0.0089
and
0.0586
ppm
day
−1
for
PCL‐covered
PCL‐free
coatings,
respectively.
It
finally
concluded
that
preliminary
result
this
can
be
promising
minimizing
in
vivo
adverse
effects
+
ions
arising
rapid
well
maintaining
efficacy
prolonged
periods,
which
ideal
preventing
risk
postimplantation
infections.
Biomedical Materials,
Год журнала:
2024,
Номер
20(1), С. 012001 - 012001
Опубликована: Ноя. 22, 2024
Abstract
Advancement
in
medicine
and
technology
has
resulted
into
prevention
of
countless
deaths
increased
life
span.
However,
it
is
important
to
note
that,
the
modern
lifestyle
altered
food
habits,
witnessed
life-style
stresses
road
accidents
leading
several
health
complications
one
primary
victims
bone
health.
More
often
than
ever,
healthcare
professionals
encounter
cases
massive
fracture,
loss
generation
critical
sized
defects.
Surgical
interventions,
through
use
grafting
techniques
are
necessary
such
cases.
Natural
grafts
(allografts,
autografts
xenografts)
however,
have
major
drawbacks
terms
delayed
rehabilitation,
lack
appropriate
donors,
infection
morbidity
that
shifted
focus
investigators
direction
synthetic
grafts.
By
employing
biomaterials
based
on
tissue
engineering
(BTE),
provide
a
more
biologically
acceptable
approach
establishing
phases
healing.
In
BTE,
various
materials
utilized
support
enhance
regeneration.
Biodegradable
polymers
like
poly-(lactic
acid),
poly-(glycolic
poly-(
ϵ
-caprolactone)
commonly
used
for
their
customizable
mechanical
properties
ability
degrade
over
time,
allowing
natural
growth.
PEG
employed
hydrogels
promote
cell
adhesion
Ceramics,
as
hydroxyapatite
beta-tricalcium
phosphate
(
β
-TCP)
mimic
mineral
attachment,
with
-TCP
gradually
resorbing
new
forms.
Composite
materials,
including
polymer-ceramic
polymer-glasses,
combine
benefits
both
ceramics/glasses
offer
enhanced
biological
properties.
collagen,
gelatin,
chitosan
matrix
attachment
formation,
also
offering
antimicrobial
Hybrid
decellularized
retain
structure
factors,
while
functionalized
scaffolds
incorporate
growth
factors
or
bioactive
molecules
further
stimulate
healing
integration.
The
current
review
article
provides
insights
could
yield
revolutionary
improvements
orthopedic
medical
fields.
introduction
section
this
focuses
statistical
information
requirements
globally
its
impact
economy.
later
section,
anatomy
human
bone,
defects
diseases
pertaining
limitations
were
detailed.
Biopolymers,
bioceramics,
biometals-based
discussed
depth
sections
followed.
then
concludes
summary
addressing
trends
future
prospects
potential
transplants.
The
repair
of
bone
graft
defects
remains
a
challenging
clinical
issue,
often
accompanied
by
the
risk
infection
in
grafted
area.
To
address
this,
we
have
developed
novel
GO-CS@ZnO
composite
material
specifically
designed
for
defect
repair.
key
innovation
this
study
lies
successful
synthesis
and
characterization
material,
which
exhibits
excellent
antibacterial
properties
favorable
biocompatibility.
was
synthesized
using
water
bath
method
characterized
XRD,
FT-IR,
XPS,
SEM.
material's
hydrophilic
confirmed
through
contact
angle
measurements.
Rigorous
testing
demonstrated
its
strong
properties,
while
cytotoxicity
tests
further
good
These
findings
highlight
significant
potential
field
repair,
offering
promising
new
approach
to
addressing
challenge.
Polymer Composites,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
ABSTRACT
Carbon
fiber
composites
are
considered
ideal
candidates
for
orthopedic
implants
due
to
their
elastic
modulus
being
similar
that
of
human
bone,
but
the
interfacial
bonding
between
carbon
fibers
and
matrix
is
still
a
challenge.
In
this
work,
multiscaled
calcium
phosphate
dihydrate
nanosheets/microsheets
(CHPDnm)
introduced
on
surface
by
one‐step
pulsed
electrodeposition
method
(PED),
which
significantly
improves
mechanical
biofriction
properties
composites.
CHPD
nanosheets
grow
in
situ
fibers,
fiber/matrix
interface
bonding.
microsheets
extend
into
enhance
cohesion
matrix.
The
improved
synergistic
effect
microsheets.
Compared
pristine
composites,
flexural
compressive
strength
CHPDnm‐reinforced
epoxy
resin/phenolic
resin/pyrolytic
(CHPDnm‐CE,
CHPDnm‐CP,
CHPDnm‐CC)
enhanced
18.1%,
118.31%,
218.0%
53.3%,
32.33%,
41.3%,
respectively.
addition,
CHPDnm‐CE,
CHPDnm‐CC
showed
reduction
80.5%,
50.0%,
21.6%
wear
rate.
This
work
provides
practical
strategy
modification
while
broadening
application
as
implants.
