Zinc–gallic acid–polylysine nanocomplexes with enhanced bactericidal activity for the treatment of bacterial keratitis

e-Polymers, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 1, 2025

Abstract Bacterial keratitis is a common infectious eye disease. Conventional antibiotic drops are becoming less effective due to resistance. Herein, we design an innovative transition metal ion-based nano-delivery system for the treatment of bacterial keratitis. Zinc (Zn 2+ )–gallic acid–poly- l -lysine nanocomplex (ZGNC) designed by coordination interaction. ZGNC stable in physiological environment and can be dissociated acidic infected microenvironment. The positively charged effectively adhered onto cells subsequently realizes situ release Zn , leading much better bactericidal effect than free . Importantly, maintains excellent activity protein-rich environment, while completely invalid eradicate bacteria environment. vivo ability further confirmed murine model. This research provides promising method treat system.

Язык: Английский

---

Self-oxygenated biomimetic nano-heterojunction combats bacterial biofilm infections via near-infrared triggered ROS storms

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162359 - 162359

Опубликована: Апрель 1, 2025

Язык: Английский

---

Effects of microplastics and tetracycline induced intestinal damage, intestinal microbiota dysbiosis, and antibiotic resistome: metagenomic analysis in young mice

Environment International, Год журнала: 2025, Номер 199, С. 109512 - 109512

Опубликована: Май 1, 2025

Microplastics (MPs) and antibiotic tetracycline (TC) are widespread in the environment constitute emerging combined contaminants. Young individuals particularly vulnerable to agents that disrupt intestinal health development. However, effects of MPs TC remain poorly understood. In this study, we developed a young mouse model exposed polystyrene MPs, either alone or combination with for 8 weeks simulate real-life dietary exposure during early life. Our findings revealed concurrent caused most severe barrier dysfunction driven by inflammatory activation oxidative imbalance. Moreover, reduced abundance potential probiotics while promoting growth opportunistic pathogens. Metagenomic analysis further indicated co-exposure enhanced bacteria carrying resistance genes (ARGs) virulence factor (VFGs), contributing dissemination potentially harmful genes. Finally, strong positive correlation was observed between microbiota dysbiosis, ARGs, VFGs. general, study highlighted hazards antibiotics mice, which provided new perspective into dynamics pathogens, VFGs early-life environments.

Язык: Английский

---

A light-responsive multilayered 3D porous Ga2O3 hydrogel for photocatalytic antibacterial therapy promoting healing of MDR S. aureus-infected wounds

Journal of Material Science and Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

---

Glucose-Activated Janus Wound Dressing for Enhanced Management of Infected and Exudative Diabetic Wounds

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 675 - 688

Опубликована: Дек. 18, 2024

Diabetic wounds, often multifactorial and affecting multiple organs, pose substantial challenges to patient well-being, drawing significant interest in biomedical engineering. The demanding wound microenvironment, marked by heightened glucose levels, local exudate, bacterial infections, emphasizes the pressing demand for advanced dressings meet escalating clinical needs. Herein, a Janus dressing with an integration of antimicrobial hydrophobic nanofiber layer 3D hydrophilic sponge was designed prepared manage utilize exudate. skillfully combined electrospun poly(ε-caprolactone) (PCL) membranes (ENMs) metal-organic frameworks (MOFs) peroxidase-like properties solvent etching, oxidase (GOx) grafted through ligand interaction. GOx acts consume while modulating pH, thus suitable pH self-supplied H2O2 were able activate catalytic activity MOFs generate •OH. Additionally, sponges are constructed using gas foaming technology, which tactfully ENMs form structure, can transport exudate layer, sufficient contact enhances dressing. Experimental results demonstrate effectiveness cascade effect GOx@PCL/MOF ENMs, ultimately releasing reactive oxygen species exhibiting robust antibacterial properties. In vivo animal experiments reveal ability mitigate methicillin-resistant Staphylococcus aureus (MRSA) infections early stages, thereby expediting healing process. study, achieved rate 54% on day 3. Our findings underscore potential promoting chronic diabetic wounds.

Язык: Английский

---

Enhanced chemodynamic therapy for biofilm eradication: A self-supplied H2O2 nanoplatform with integrated photothermal property

Journal of Material Science and Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

---