Host Defense Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Activities toward Phytopathogens to Alleviate Antimicrobial Resistance in Agriculture DOI
Sheng Chen, Min Zhou, Ximian Xiao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Given the limited types of agricultural bactericides and rapid emergence antimicrobial resistance, bacterial plant diseases pose a serious threat to production, which calls for effective agents with low propensity resistance. Host defense peptides (HDPs) have drawn significant attention their broad-spectrum activity. In this study, we found that HPD-mimicking poly(2-oxazoline) Gly-POX20 exhibits potent activity against phytopathogens, superior antibacterial selectivity proteolytic stability compared natural HDP melittin. Compared commonly used bactericides, displays more efficient antibiofilm lower resistance than does antibiotic streptomycin, likely due its mechanism, involves DNA interaction generating lethal doses ROS. vivo studies reveal is in preventing treating phytopathogens without observable damage tissues, suggesting could be promising bactericide applications.

Язык: Английский

Transmission Dynamics and Novel Treatments of High Risk Carbapenem-Resistant Klebsiella pneumoniae: The Lens of One Health DOI Creative Commons

Jiaying Zhu,

Taoyu Chen, Yanmin Ju

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1206 - 1206

Опубликована: Сен. 12, 2024

The rise of antibiotic resistance and the dwindling antimicrobial pipeline have emerged as significant threats to public health. emergence carbapenem-resistant

Язык: Английский

Процитировано

10
Multipurpose β-Cyclodextrin-Involved nanospherical Aggregates: Self-Assembly Process, foliar Adhesion, and promising applications for kiwifruit and rice Protections DOI
Pan Liu, Jinghan Yang,

Juan Liu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160385 - 160385

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Host Defense Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Activities toward Phytopathogens to Alleviate Antimicrobial Resistance in Agriculture DOI
Sheng Chen, Min Zhou, Ximian Xiao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Given the limited types of agricultural bactericides and rapid emergence antimicrobial resistance, bacterial plant diseases pose a serious threat to production, which calls for effective agents with low propensity resistance. Host defense peptides (HDPs) have drawn significant attention their broad-spectrum activity. In this study, we found that HPD-mimicking poly(2-oxazoline) Gly-POX20 exhibits potent activity against phytopathogens, superior antibacterial selectivity proteolytic stability compared natural HDP melittin. Compared commonly used bactericides, displays more efficient antibiofilm lower resistance than does antibiotic streptomycin, likely due its mechanism, involves DNA interaction generating lethal doses ROS. vivo studies reveal is in preventing treating phytopathogens without observable damage tissues, suggesting could be promising bactericide applications.

Язык: Английский

Процитировано

0