ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

Herein, we demonstrate a one-step, scalable, solution-processed method for the growth of nickel sulfide (NiS) nanostructures using single-source precursors (SSPs) on flexible substrate as versatile framework simultaneous detection four DNA nucleobases. The as-grown NiS exhibit broad bandgap range and spherical morphology with high surface area significant porosity, confirmed by SEM, TEM, BET analysis. Consequently, NiS/Ni-foam electrode exhibited remarkable electrochemical performance toward oxidation A, G, T, C due to its large area, activity, efficient electron transfer capacity. Under optimum conditions, demonstrated selective all nucleobases over wide linear from 200 1000 μM A 50 500 T C, low limit 159 147.6 16.8 45.9 along sensitivity 1.2 × 10-4 M-1 6.1 10-3 3.0 C. as-fabricated revealed excellent reproducibility stability nucleobase reliable DPV response under different bending twisting conditions. For immediate practical application, was utilized quantify concentration in calf thymus Escherichia coli (E. coli) DNA, resulting (G + C)/(A T) ratio 0.79 1.10, respectively. This simple, cost-effective, paves way development non-invasive, wearable biosensors potential applications early disease detection.

Язык: Английский