Cancers, Год журнала: 2025, Номер 17(2), С. 240 - 240
Опубликована: Янв. 13, 2025
The regucalcin gene is located on the X chromosome, comprising seven exons and six introns. This protein are expressed in various tissues cells predominantly human liver, kidney, adrenal tissues. Regucalcin expression enhanced via a mechanism mediated by several signaling molecules transcription factors. plays multifunctional role cellular regulation maintaining cell homeostasis. In addition, has been implicated metabolic disorders diseases. particular, as novel suppressor types of cancer patients. Increased suppresses growth cells, suggesting its pivotal suppressing tumor development. survival time patients prolonged with increased adhesion, migration, invasion, bone metastatic activity blocked overexpression regucalcin, promoting dormancy Interestingly, also found serum, character biomarker extracellular shown to suppress cells' activity. Thus, may play vital Alteration serum levels physiological pathophysiological conditions influence microenvironment. review will discuss potential critical
Язык: Английский