Alzheimer s & Dementia, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
The retinal nerve fiber layer (RNFL) or ganglion cell-inner plexiform (GC-IPL) is associated with cognitive impairment. However, the relationship between asymmetry and frailty (CF) remains unknown.
Язык: Английский
Frontiers in Public Health, Год журнала: 2025, Номер 13
Опубликована: Фев. 18, 2025
The relationship between handgrip strength (HGS) at baseline and subsequent depressive symptoms among middle-aged older Chinese adults remains highly uncertain. This research endeavored to investigate the effect of functional limitation on association these two variables. A total 5,684 participants aged ≥45 years from China Longitudinal Study Health Retirement (CHARLS) were enrolled, using data 2015 2018 waves. Functional was evaluated based participants' self-reported basic activities daily living (BADL) instrumental (IADL). Logistic regression models utilized analyze HGS symptoms, bootstrap analysis performed explore potential mediating role limitation. After adjusting for confounders, an inverse correlation detected (B = -0.885, p < 0.001), a positive found 1.054, 0.001). mediated size through a*b -0.933 (BCa 95% CI: -1.224, -0.642). had significant impact 18.9% overall association. Among senior population, accounted connection symptoms. Interventions targeting enhancement muscle should be regarded as crucial elements maintaining physical function preventing
Язык: Английский
Процитировано
0
Brain and Behavior, Год журнала: 2025, Номер 15(3)
Опубликована: Март 1, 2025
ABSTRACT Background Prior research has consistently shown an association between muscle strength and various metabolic diseases. However, the relationship cognitive impairment remains elusive. Methods Using data from 2011–2014 National Health Nutrition Examination Survey (NHANES), we investigated impairment. We used multivariate logistic regression, restricted cubic spline regression (RCS), threshold effects to investigate impact of on function. In addition, analyzed correlation in subgroups age, gender, race, education, smoking status, drinking hypertension, diabetes, heart disease. Results 2124 participants were ultimately included for further analysis. Multivariate trend testing, RCS analysis showed a non‐linear negative Threshold effect suggests that when reaches certain value, this undergoes significant changes. three function scoring tests, interaction was only observed racial subgroup. Conclusion This study function, which may have effect. Further longitudinal studies are needed elucidate its potential mechanisms.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 21, 2025
Abstract This study investigated the association between handgrip strength (HGS) asymmetry and weakness with cognitive function depressive symptoms among 920 community-dwelling adults aged above 60 years in suburban Shanghai. Participants were selected using a multistage cluster-stratified sampling approach. Assessments included HGS measured dynamometer, Montreal Cognitive Assessment (MoCA) for cognition, Geriatric Depression Scale (GDS) symptoms. Restricted cubic splines revealed positive dominant MoCA scores, indicating better performance, negative GDS suggesting fewer The ratio scores varied by sex. Women alone (odds (OR) = 2.00, 95% confidence interval (CI) 1.17–3.37), (OR 1.93, CI 1.14–3.29), or together 2.57, 1.48–4.46) had significantly increased risk of impairment. However, no such associations observed men. These findings suggest that asymmetrical may be associated higher decline symptoms, particularly women. emphasizes need sex-specific assessments prevention strategies to address mental health issues older adults.
Язык: Английский
Процитировано
0
European Geriatric Medicine, Год журнала: 2024, Номер unknown
Опубликована: Июнь 22, 2024
Язык: Английский
Процитировано
0
Epidemiology and Health, Год журнала: 2024, Номер unknown, С. e2024057 - e2024057
Опубликована: Июнь 25, 2024
The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with aim identifying older adults an increased risk dementia preclinical phase. TIGER, a population-based prospective cohort, recruited 605 629 (total 1,234) (aged 65 above) at baseline (2011-2013 2019-2022) phase I II, respectively. Participants have undergone structured questionnaires, assessments, physical exams, biological specimen collections biennial follow-ups date. By 2022, TIGER has included 4 follow-ups, participants comprising 53.9% female having mean age 73.2 years baseline. After 8-year follow-up, annual attrition rate 6.1%, reflecting combination 9.9% who passed away 36.2% dropped out. published novel multidisciplinary research on cognitive-related outcomes adults, including environmental exposures (indoor ambient air pollution), multimorbidity, sarcopenia, frailty, biomarkers (brain retinal images, renal inflammatory markers), diet. TIGER's meticulous design, data, findings complex etiology impairment offering valuable insights into factors that can be used predict prevent
Язык: Английский
Процитировано
0
Alzheimer s & Dementia, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
The retinal nerve fiber layer (RNFL) or ganglion cell-inner plexiform (GC-IPL) is associated with cognitive impairment. However, the relationship between asymmetry and frailty (CF) remains unknown.
Язык: Английский
Процитировано
0