International Journal of Surgery Open, Год журнала: 2024, Номер 62(6), С. 821 - 822
Опубликована: Сен. 30, 2024
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 1, 2025
Hypertension, a major global health issue and leading cause of death, is often under-assessed by traditional metrics like Body Mass Index which fail to capture comprehensive cardiovascular risks associated with obesity. The Cardiometabolic (CMI), evaluates abdominal obesity dyslipidemia, offers more accurate assessment visceral fat metabolic dysfunction. In this study, we analyzed data from 45,250 participants the National Health Nutrition Examination Survey spanning 1999 2020. Using multivariable logistic regression, explored association between CMI hypertension, employing Restricted Cubic Spline analysis assess non-linear relationships two-piecewise linear regression identify threshold effects. Subgroup analyses confirmed consistency our findings across various demographic clinical characteristics. Findings that hypertensive exhibited significantly higher levels (median 0.46 vs. 0.73), adjusted showing notable increased hypertension prevalence (OR 1.30, 95% CI 1.25-1.35, P < 0.01), characterized nonlinear L-shaped curve critical identified at value 1.37. revealed pronounced impact on in females. These results underscore CMI's potential enhance risk diverse U.S. populations.
Язык: Английский
Процитировано
2
Cells, Год журнала: 2024, Номер 13(17), С. 1413 - 1413
Опубликована: Авг. 24, 2024
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer's disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form soluble (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by produces active IL-1β, pores cell death (pyroptosis). In accord, countered injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces inflammation, improves repair following injury. inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.
Язык: Английский
Процитировано
8
Journal of Health Population and Nutrition, Год журнала: 2024, Номер 43(1)
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
7
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 10, 2025
This study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain potential of as a predictive biomarker for research employed data from National Health Nutrition Examination Survey (NHANES) 2013 2016. Weighted logistic regression analyses were investigate Restricted cubic spline (RCS) executed males females scrutinize non-linear correlation Subsequently, piecewise analysis carried out based on RCS findings. In females, notably lower in those with hyperlipidemia comparison without this condition (P < 0.05), No significant variation demonstrated > 0.05). participants stratified by sex subjected model. When log2-transformed, it significantly negatively associated risk even after adjusting all covariates (OR 0.45, 95% CI 0.24–0.82), which not observed 1.14, 0.63–2.06). same results third tertile α-Klotho. Moreover, suggested nonlinear 0.01). inflection point found be 1106.87 pg/mL. model revealed that when exceeded pg/mL, link no longer investigation highlights sex-based exhibited negative hyperlipidemia, displaying saturation effect. Serum emerges promising biological marker among females.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 10, 2025
Preserved ratio impaired spirometry (PRISm) is a prevalent yet under-researched state of diminished lung function, which has been proposed as pre-clinical abnormal associated with chronic obstructive pulmonary disease (COPD) or early-stage COPD. PRISm closely cardiovascular disease. Preventing and improving quality life in subjects important. We aimed to examined the relationship between American Heart Association's Life's Essential 8 (LE8) PRISm. This cross-sectional study utilized data 2,869 adults aged ≥ 20 years from National Health Nutrition Examination Survey (NHANES) 2007–2012. Multivariable logistic regression models were employed examine association LE8 score, health behavior factor each component Moreover, explored this correlation greater depth using restricted cubic spline curves subgroup analyses. Of participants, mean age was 44.09 ± 0.44 years, 316 (11.01%) defined having In fully adjusted models, higher scores reduced odds for (OR = 0.97; 95% CI, 0.96–0.98). A linear score observed. Similar patterns emerged subscores, particularly stronger factors analysis, inverse significantly more pronounced among those high income. lower likelihood developing Promoting optimal adherence metrics may improve offers meaningful approach its prevention management.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 11, 2025
Ethylene oxide (EO) is an industrial chemical used in the production of both consumer and non-consumer products.Additionally, it utilized as a gaseous sterilant for medical devices. As anti-aging hormone, kloth involved various physiological processes. At present, association between EO exposure klotho remains uncertain. In this retrospective cross-sectional study, 1696 participants aged 40-79 years 2013-2016 National Health Nutrition Examination Survey were included. was measured using hemoglobin adducts (HbEO) human whole blood or erythrocytes. Klotho levels also samples. Linear regression, smooth curve fitting, subgroup analyses to assess whether HbEO associated with level. After full adjustment confounders, negative log2HbEO observed after multivariate (β=-17.29, 95% CI = - 28.42 ~ 6.17, P 0.002). When categorized into quintiles, fifth quintile exhibited significant differences compared lowest (β=-70.79, 122.54 19.04, 0.007). The fitting shows inverse "L-shaped" relationship (P nonlinearity 0.04). summary, nonlinear found klotho. Further research required confirm causality connection clarify underlying mechanisms.
Язык: Английский
Процитировано
0
Опубликована: Авг. 5, 2024
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer’s disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form, soluble form (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation, appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by NF-κB, produces active IL-1β, pores cell death (pyroptosis). In accord, countered inflammation injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces improves repair following injury. Inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.
Язык: Английский
Процитировано
2
Опубликована: Авг. 12, 2024
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer’s disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form, soluble form (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation, appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by NF-κB, produces active IL-1β, pores cell death (pyroptosis). In accord, countered inflammation injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces improves repair following injury. Inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.
Язык: Английский
Процитировано
1
Nutrition Journal, Год журнала: 2024, Номер 23(1)
Опубликована: Авг. 20, 2024
Aging is an inevitable biological process. Accelerated aging renders adults more susceptible to chronic diseases and increases their mortality rates. Previous studies have reported the relationship between lifestyle factors phenotypic aging. However, intrinsic factors, such as reproductive remains unclear.
Язык: Английский
Процитировано
1
Diabetology & Metabolic Syndrome, Год журнала: 2024, Номер 16(1)
Опубликована: Ноя. 1, 2024
Both anti-aging protein α-Klotho and the triglyceride-glucose (TyG) index hold predictive value for incidence, progression, outcomes of cardiovascular disease, diabetes many other diseases. However, their relationship remains unclear.
Язык: Английский
Процитировано
0