Mapping the intersection of HIV and Alzheimer’s disease: a bibliometric analysis of emerging research trends DOI Creative Commons

Hao Zhang,

S. C. Yuan,

H. -R. Bao

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 29, 2025

Background HIV and Alzheimer’s disease (AD) are significant global health challenges with overlapping neuroinflammatory protein aggregation mechanisms. Understanding their intersection is critical for advancing therapeutic strategies, particularly in aging populations. Objective This study aims to provide a comprehensive bibliometric analysis of research trends at the AD, identify emerging themes, highlight key contributors this interdisciplinary field. Methods Using Web Science Core Collection, we retrieved 4,856 articles reviews published between 1994 2025. Bibliometric was conducted VOSviewer, CiteSpace, R software examine publication trends, international collaboration, institutional contributions, journal dynamics, author networks, thematic evolution. Results The reveals 14.18% annual growth rate publications, U.S. leading productivity, followed by China, Germany, Japan. Key institutions include NIH University California System, while journals such as Journal Biological Chemistry PLOS ONE show growth. Prominent authors Masliah, Eliezer, Heaton, RK. Research highlights overlap HIV-associated neurocognitive disorders (HAND) emphasizing shared mechanisms like neuroinflammation, aggregation, blood–brain barrier disruption. Recent advances focus on cerebrospinal fluid biomarkers, oxidative stress, impact antiretroviral therapy (ART) neurological outcomes. Studies increasingly explore role advanced methodologies, including machine learning, elucidating endoplasmic reticulum misfolding. Conclusion underscores dynamic rapidly evolving landscape driven collaborative efforts technological advancements. Future should prioritize longitudinal studies, mechanistic insights, translational applications address unanswered questions

Язык: Английский

Mapping the intersection of HIV and Alzheimer’s disease: a bibliometric analysis of emerging research trends DOI Creative Commons

Hao Zhang,

S. C. Yuan,

H. -R. Bao

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 29, 2025

Background HIV and Alzheimer’s disease (AD) are significant global health challenges with overlapping neuroinflammatory protein aggregation mechanisms. Understanding their intersection is critical for advancing therapeutic strategies, particularly in aging populations. Objective This study aims to provide a comprehensive bibliometric analysis of research trends at the AD, identify emerging themes, highlight key contributors this interdisciplinary field. Methods Using Web Science Core Collection, we retrieved 4,856 articles reviews published between 1994 2025. Bibliometric was conducted VOSviewer, CiteSpace, R software examine publication trends, international collaboration, institutional contributions, journal dynamics, author networks, thematic evolution. Results The reveals 14.18% annual growth rate publications, U.S. leading productivity, followed by China, Germany, Japan. Key institutions include NIH University California System, while journals such as Journal Biological Chemistry PLOS ONE show growth. Prominent authors Masliah, Eliezer, Heaton, RK. Research highlights overlap HIV-associated neurocognitive disorders (HAND) emphasizing shared mechanisms like neuroinflammation, aggregation, blood–brain barrier disruption. Recent advances focus on cerebrospinal fluid biomarkers, oxidative stress, impact antiretroviral therapy (ART) neurological outcomes. Studies increasingly explore role advanced methodologies, including machine learning, elucidating endoplasmic reticulum misfolding. Conclusion underscores dynamic rapidly evolving landscape driven collaborative efforts technological advancements. Future should prioritize longitudinal studies, mechanistic insights, translational applications address unanswered questions

Язык: Английский

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