European Journal of Gastroenterology & Hepatology,
Год журнала:
2023,
Номер
36(2), С. 210 - 219
Опубликована: Ноя. 30, 2023
Objective
The
possible
interaction
of
dietary
flavonoid
intake
and
sleep
on
non-alcoholic
fatty
liver
disease
(NAFLD)
has
not
been
well
studied.
This
study
investigated
the
between
trouble
sleeping
risk
NAFLD.
Methods
Three
discrete
National
Health
Nutrition
Examination
Survey
data
cycles
from
2007
to
2010
2017
2018
were
used.
NAFLD
was
diagnosed
by
a
US
Fatty
Liver
Index
≥30.
A
questionnaire
sleeping.
Univariate
multivariate
logistic
regression,
restricted
cubic
spline
(RCS)
subgroup
analyses
used
evaluate
association
flavonoids,
We
employed
relative
excess
due
interaction,
attributable
proportion
synergy
index
additive
interactions.
Results
Ultimately,
5056
participants
enrolled,
higher
anthocyanidins
flavanones
negatively
correlated
with
Conversely,
positively
associated
These
correlations
remained
stable
after
adjusting
for
confounders,
there
sex
difference
in
this
relationship.
In
RCS
model,
anthocyanins
non-linearly
related
NAFLD,
while
showed
negative
linear
Moreover,
synergistic
interplay
low
anthocyanin
similar
relationship
existed
flavanone
intake.
Conclusion
Anthocyanin
associated,
whereas
risk.
There
effect
same
ABSTRACT
The
most
frequent
type
of
breast
cancer
in
women
is
infiltrating
ductal
carcinoma,
followed
by
lobular
carcinoma
and
triple‐negative
cancer,
which
account
for
10%–15%
cases.
Since
this
disease
not
aggressive
its
early
stages
thus
does
flee
with
the
duct
perspective,
Epidermal
Growth
Factor
Receptor
(EGFR)
was
chosen
relevance
stage
0
as
a
primary
target.
study
aimed
to
evaluate
protective
effects
19
flavonoids
against
cancer.
In
addition,
pharmacokinetics
investigations,
molecular
docking,
free
energy
calculations,
dynamics
simulations
were
used
interactions,
stability,
draggability
between
phytoconstituents
EGFR.
acquired
results
showed
that
myricetin,
has
been
compared
raloxifene,
top
docked
score
compound
from
list
flavonoids;
docking
−9.26
kcal/mol,
standard
raloxifene
−5.39
kcal/mol
epidermal
growth
factor
receptor.
ADME
profile
shows
drug‐like
properties.
MD
revealed
myricetin
complex
more
stable
than
complex,
pharmacophore
modeling
studies
validated
hydrogen
bonding
interactions.
PASS
online
program
predicted
biological
spectrum
cancer‐causing
enzyme.
Key
parameters
like
RMSD,
RMSF,
RoG,
bonds,
PCA,
DCCM,
FEL
analysis
indicated
better
stability
myricetin.
These
suggest
promising
drug
candidate
Archives of Physiology and Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Март 31, 2025
Background:
Osteoporosis
poses
a
global
health
challenge,
particularly
with
an
ageing
population.
Quercetin,
isorhamnetin,
avicularin,
isoquercetin,
quercitrin,
and
taxifolin
are
natural
flavonoids
similar
structure
that
induce
ontogenesis.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Identifying
primary
estrogen
receptor
(ER)
agonists
in
municipal
sewage
is
essential
for
ensuring
the
health
of
aquatic
environments.
Given
complex
and
variable
chemical
composition
sewage,
predominant
ER
remain
unclear.
High-resolution
mass
spectrometry
(HRMS)-based
models
have
been
developed
to
predict
compound
bioactivity
matrices,
but
further
optimization
needed
effectively
bridge
HRMS
features
with
agonists.
To
address
this
challenge,
an
FT-GNN
(fragmentation
tree-based
graph
neural
network)
model
was
proposed.
limited
data
class
imbalance,
augmentation
performed
using
predictions
within
applicability
domain
(AD)
oversampling
technique
(OTE).
Model
development
results
demonstrated
that
integrating
improved
balanced
accuracy
(bACC)
value
by
6%-31%.
The
model,
a
high
bACC
identify
more
true
agonists,
efficiently
classified
tens
thousands
unidentified
reducing
postprocessing
workload
nontargeted
screening.
Analysis
agonist
transformation
during
treatment
revealed
anaerobic
stage
as
key
both
their
removal
formation.
Estrogenic
effect
balance
analysis
suggests
α-E2
9,11-didehydroestriol
may
be
two
previously
overlooked
Collectively,
application
are
crucial
advancements
toward
credible
tracking
efficient
control
estrogenic
risks
water.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 26, 2025
Introduction
Phytoestrogens,
with
estrogenic
activity,
are
commonly
found
across
the
Fabaceae
family.
Here
we
develop
methods
that
use
phylogeny
and
ethnomedicinal
information
in
order
to
identify
candidate
species
for
novel
phytoestrogens.
Method
We
selected
traditionally
used
as
aphrodisiacs
or
applications
control
fertility
(aphrodisiac-fertility
species),
create
a
cross-cultural
dataset
of
use.
Using
Fabaceae,
“hot
nodes”
were
lineages
higher
number
aphrodisiac-fertility
uses.
The
known
distribution
flavonoids
was
determine
whether
phytoestrogen-containing
associated
nodes”.
Additionally,
examined
overlap
uses
neurological
applications,
hypothesising
such
may
have
bioactive
compounds
properties.
Lastly,
“aphrodisiac-fertility
hot
node”
without
previously
identified.
Results
showed
nodes
more
likely
contain
(21%
major
group
phytoestrogens,
compared
(11%
species).
when
aphrodisiac
limited
those
62%
within
flavonoids.
Discussion
recognised
43
high-priority
nodes,
these
might
represent
promising
targets
future
studies
on
results
demonstrated
combining
phylogenetic
data
guide
discovery
therapeutic
potential.
Phytoestrogens
(PEs)
are
estrogen-like
nonsteroidal
compounds
derived
from
plants
(e.g.,
nuts,
seeds,
fruits
and
vegetables)
fungi
that
structurally
similar
to
17β-estradiol.
PEs
bind
all
types
of
estrogen
receptors,
including
ERα
ERβ
the
nuclear
a
membrane-bound
receptor
known
as
G
protein-coupled
(GPER).
As
endocrine-disrupting
chemicals
(EDCs)
with
pro‐
or
antiestrogenic
properties,
can
potentially
disrupt
hormonal
regulation
homeostasis,
resulting
in
developmental
reproductive
abnormalities.
However,
lack
diet
does
not
result
development
deficiency
symptoms.
To
properly
assess
benefits
risks
associated
use
PE-rich
diet,
it
is
necessary
distinguish
between
endocrine
disruption
(endocrine-mediated
adverse
effects)
nonspecific
effects
on
system.
Endometriosis
an
estrogen-dependent
disease
unknown
etiopathogenesis,
which
tissue
lining
uterus
(the
endometrium)
grows
outside
subsequent
complications
being
manifested
local
inflammatory
reactions.
affects
10–15%
women
age
chronic
pelvic
pain,
dysmenorrhoea,
dyspareunia
infertility.
In
this
review,
endocrine-disruptive
actions
reviewed
context
endometriosis
determine
whether
has
positive
negative
effect
risk
course
endometriosis.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7229 - 7229
Опубликована: Окт. 23, 2023
This
research
is
based
on
the
concept
that
mitochondria
are
a
promising
target
for
anticancer
therapy,
including
thatassociated
with
use
of
oxidative
phosphorylation
blockers
(mitochondrial
poisons).
Liposomes
L-α-phosphatidylcholine
(PC)
and
cholesterol
(Chol)
modified
cationic
surfactants
triphenylphosphonium
(TPPB-n,
where
n
=
10,
12,
14,
16)
imidazolium
(IA-n(OH),
head
groups
were
obtained.
The
physicochemical
characteristics
liposomes
at
different
surfactant/lipid
molar
ratios
determined
by
dynamic/electrophoretic
light
scattering,
transmission
electron
microscopy,
spectrophotometry.
hydrodynamic
diameter
all
systems
was
within
120
nm
polydispersity
index
no
more
than
0.24
even
after
2
months
storage.
It
shown
cationization
leads
to
an
increase
in
internalization
nanocontainers
pancreatic
carcinoma
(PANC-1)
duodenal
adenocarcinoma
(HuTu
80)
cells
compared
unmodified
liposomes.
Also,
using
confocal
it
TPPB-14
IA-14(OH)
statistically
better
colocalize
tumor
ones.
At
next
stage,
mitochondrial
poison
rotenone
(ROT)
loaded
into
optimal
loading
concentration
ROT
0.1
mg/mL.
Korsmeyer-Peppas
Higuchi
kinetic
models
used
describe
release
mechanism
from
vitro.
A
significant
reduction
IC
