European Journal of Gastroenterology & Hepatology,
Год журнала:
2023,
Номер
36(2), С. 210 - 219
Опубликована: Ноя. 30, 2023
Objective
The
possible
interaction
of
dietary
flavonoid
intake
and
sleep
on
non-alcoholic
fatty
liver
disease
(NAFLD)
has
not
been
well
studied.
This
study
investigated
the
between
trouble
sleeping
risk
NAFLD.
Methods
Three
discrete
National
Health
Nutrition
Examination
Survey
data
cycles
from
2007
to
2010
2017
2018
were
used.
NAFLD
was
diagnosed
by
a
US
Fatty
Liver
Index
≥30.
A
questionnaire
sleeping.
Univariate
multivariate
logistic
regression,
restricted
cubic
spline
(RCS)
subgroup
analyses
used
evaluate
association
flavonoids,
We
employed
relative
excess
due
interaction,
attributable
proportion
synergy
index
additive
interactions.
Results
Ultimately,
5056
participants
enrolled,
higher
anthocyanidins
flavanones
negatively
correlated
with
Conversely,
positively
associated
These
correlations
remained
stable
after
adjusting
for
confounders,
there
sex
difference
in
this
relationship.
In
RCS
model,
anthocyanins
non-linearly
related
NAFLD,
while
showed
negative
linear
Moreover,
synergistic
interplay
low
anthocyanin
similar
relationship
existed
flavanone
intake.
Conclusion
Anthocyanin
associated,
whereas
risk.
There
effect
same
Genes,
Год журнала:
2024,
Номер
15(2), С. 204 - 204
Опубликована: Фев. 4, 2024
Sophora
flavescens
is
a
medicinal
herb
distributed
widely
in
Japan
and
it
has
been
used
to
treat
various
diseases
symptoms.
To
explore
its
pharmacological
use,
we
examined
the
estrogenic
activity
of
four
prenylated
flavonoids,
namely
kurarinone,
kushenols
A
I,
sophoraflavanone
G,
which
are
characterized
by
lavandulyl
group
at
position
8
ring
A,
but
have
variations
hydroxyl
positions
3
(ring
C),
5
A)
4'
B).
These
flavonoids
were
via
cell
proliferation
assays
using
sulforhodamine
B,
Western
blotting,
RT-PCR,
corresponding
cell,
protein,
transcription
assays,
respectively,
based
on
estrogen
action
mechanisms.
All
employed
here
found
weak
clear
activities
for
examined.
Furthermore,
inhibited
an
receptor
antagonist,
suggesting
that
likely
being
mediated
receptors.
However,
there
differences
activity,
attributable
4',
absent
kushenol
A.
While
kurarinone
G
reported
before,
best
our
knowledge,
no
such
reports
I.
Therefore,
this
study
represents
first
report
their
activity.
European Journal of Gastroenterology & Hepatology,
Год журнала:
2023,
Номер
36(2), С. 210 - 219
Опубликована: Ноя. 30, 2023
Objective
The
possible
interaction
of
dietary
flavonoid
intake
and
sleep
on
non-alcoholic
fatty
liver
disease
(NAFLD)
has
not
been
well
studied.
This
study
investigated
the
between
trouble
sleeping
risk
NAFLD.
Methods
Three
discrete
National
Health
Nutrition
Examination
Survey
data
cycles
from
2007
to
2010
2017
2018
were
used.
NAFLD
was
diagnosed
by
a
US
Fatty
Liver
Index
≥30.
A
questionnaire
sleeping.
Univariate
multivariate
logistic
regression,
restricted
cubic
spline
(RCS)
subgroup
analyses
used
evaluate
association
flavonoids,
We
employed
relative
excess
due
interaction,
attributable
proportion
synergy
index
additive
interactions.
Results
Ultimately,
5056
participants
enrolled,
higher
anthocyanidins
flavanones
negatively
correlated
with
Conversely,
positively
associated
These
correlations
remained
stable
after
adjusting
for
confounders,
there
sex
difference
in
this
relationship.
In
RCS
model,
anthocyanins
non-linearly
related
NAFLD,
while
showed
negative
linear
Moreover,
synergistic
interplay
low
anthocyanin
similar
relationship
existed
flavanone
intake.
Conclusion
Anthocyanin
associated,
whereas
risk.
There
effect
same
