Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective

Phytomedicine, Год журнала: 2023, Номер 122, С. 155142 - 155142

Опубликована: Окт. 11, 2023

Язык: Английский

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Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Nutrients, Год журнала: 2023, Номер 15(22), С. 4722 - 4722

Опубликована: Ноя. 8, 2023

Inflammatory bowel disease (IBD) is a chronic and recurrent disease. It has been observed that the incidence prevalence of IBD are increasing, which consequently raises risk developing colon cancer. Recently, regulation intestinal barrier by probiotics become an effective treatment for colitis. Akkermansia muciniphila-derived extracellular vesicles (Akk EVs) nano-vesicles contain multiple bioactive macromolecules with potential to modulate barrier. In this study, we used ultrafiltration in conjunction high-speed centrifugation extract Akk EVs. A lipopolysaccharide (LPS)-induced RAW264.7 cell model was established assess anti-inflammatory effects found EVs were able be absorbed cells significantly reduce expression nitric oxide (NO), TNF-α, IL-1β (p < 0.05). We explored preventative on colitis regulating using mouse caused dextran sulfate sodium (DSS). The findings demonstrated effectively prevented symptoms reduced colonic tissue injury. Additionally, enhanced effectiveness elevating MUC2 (0.53 ± 0.07), improving mucus integrity, reducing permeability Moreover, increased proportion beneficial bacteria Firmicutes (33.01 0.09%) downregulated harmful Proteobacteria (0.32 0.27%). These suggest possess ability regulate immune responses, protect barriers, gut microbiota. research presents intervention approach prevent

Язык: Английский

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Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties

Phytomedicine, Год журнала: 2023, Номер 123, С. 155251 - 155251

Опубликована: Ноя. 28, 2023

Язык: Английский

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Reducing Immunoreactivity of Gluten Peptides by Probiotic Lactic Acid Bacteria for Dietary Management of Gluten-Related Diseases

Nutrients, Год журнала: 2024, Номер 16(7), С. 976 - 976

Опубликована: Март 27, 2024

Immunoreactive gluten peptides that are not digested by peptidases produced humans can trigger celiac disease, allergy and non-celiac hypersensitivity. The aim of this study was to evaluate the ability selected probiotic strains hydrolyze immunoreactive gliadin identify peptidase-encoding genes in genomes most efficient strains. Residual immunoreactivity measured after one- or two-step hydrolysis using commercial enzymes bacterial peptidase preparations G12 R5 immunoenzymatic assays. Peptidase from Lacticaseibacillus casei LC130, paracasei LPC100 Streptococcus thermophilus ST250 significantly reduced peptides, including 33-mer, effect markedly higher when a mixture these used. In silico genome analyses L. LC130 revealed presence encoding with potential bonds proline-rich peptides. This suggests S. ST250, especially used as mixture, have could be administered patients on restricted gluten-free diet help treat gluten-related diseases.

Язык: Английский

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Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults

Journal of the American Heart Association, Год журнала: 2024, Номер 13(13)

Опубликована: Июнь 27, 2024

The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers including daidzein, glycitein, genistein, equol (a gut microbial metabolite daidzein), equol-predicting species with risk markers.

Язык: Английский

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Weight Loss Promotion in Individuals with Obesity through Gut Microbiota Alterations with a Multiphase Modified Ketogenic Diet

Nutrients, Год журнала: 2023, Номер 15(19), С. 4163 - 4163

Опубликована: Сен. 27, 2023

The occurrence of obesity and related metabolic disorders is rising, necessitating effective long-term weight management strategies. With growing interest in the potential role gut microbes due to their association with responses different loss diets, understanding mechanisms underlying interactions between diet, microbiota, remains a challenge. This study aimed investigate impact multiphase dietary protocol, incorporating an improved ketogenic diet (MDP-i-KD), on microbiota. Using metagenomic sequencing, we comprehensively analyzed taxonomic functional composition microbiota 13 participants before after 12-week MDP-i-KD intervention. results revealed significant reduction BMI (9.2% loss) among obese following Machine learning analysis identified seven key microbial species highly correlated MDP-i-KD, Parabacteroides distasonis exhibiting highest response. Additionally, co-occurrence network post-weight-loss demonstrated healthier state. Notably, pathways nucleotide biosynthesis, aromatic amino acid synthesis, starch degradation were enriched pre-intervention positively BMI. Furthermore, associated obesity, such as Blautia obeum Ruminococcus torques, played pivotal roles regulating these activities. In conclusion, intervention may assist by modulating functions distasonis, obeum, torques could be targets for microbiota-based interventions.

Язык: Английский

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The potential of flavonoids in hepatic fibrosis: A comprehensive review

Phytomedicine, Год журнала: 2024, Номер 133, С. 155932 - 155932

Опубликована: Авг. 8, 2024

Язык: Английский

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Non/Low-Caloric Artificial Sweeteners and Gut Microbiome: From Perturbed Species to Mechanisms

Metabolites, Год журнала: 2024, Номер 14(10), С. 544 - 544

Опубликована: Окт. 11, 2024

Non/low-caloric artificial sweeteners (NAS) are recognized as chemical additives substituting sugars to avoid caloric intake and subsequent sugar-derived diseases such diabetes hyperglycemia. Six NAS have been claimed safe authorized by the US Food Drug Administration (FDA) for public use, with acceptable daily information available: aspartame, acesulfame-K, saccharin, sucralose, neotame, advantame. However, impacts of on gut microbiome raised potential concerns, since sporadic research revealed NAS-induced microbial changes in gastrointestinal tracts alterations microbiome-host interactive metabolism.

Язык: Английский

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Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study

Nutrients, Год журнала: 2023, Номер 15(19), С. 4260 - 4260

Опубликована: Окт. 5, 2023

Gout is a form of prevalent and painful inflammatory arthritis characterized by elevated serum urate (SUA) levels. The gut microbiota (GM) believed to influence the development gout SUA Our study aimed explore causal relationship between GM composition gout, as well levels, utilizing two-sample Mendelian Randomization (MR) approach. A total 196 taxa from five levels were available for analysis. We identified associated with 10 gout. In reverse MR analysis, we discovered that affected taxa, while influenced 30 taxa. Combining existing research, our unveiled potential negative feedback loop phylum Actinobacteria establishing connections also proposed two novel associations connecting (genus Faecalibacterium genus Prevotella9), These findings provide compelling evidence relationships specific contributing valuable insights treatment

Язык: Английский

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The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors

Cancers, Год журнала: 2024, Номер 16(8), С. 1575 - 1575

Опубликована: Апрель 19, 2024

Head and neck squamous cell carcinoma (HNSCC) is the most common histological form of head tumors (HNTs), which originate from epithelium lips oral cavity, pharynx, larynx, salivary glands, nasal sinuses. The main risk factors include consumption tobacco in all forms alcohol, as well infections with high-risk human papillomaviruses or Epstein–Barr virus. Regardless etiological agent, developing different types HNTs two to more than six times higher males females. reason for such disparities probably lies a combination both biological psychosocial factors. Therefore, it hypothesized that exposure female sex hormones, primarily estrogen, provides women protection against formation metastasis HNTs. In this review, we synthesized available knowledge on role estrogen receptors (ERs) development progression HNTs, special emphasis membrane ERs, are much less studied. We can summarize addition epidemiologic studies unequivocally pointing protective effect women, an increased expression nuclear ERα, ERβ, ERα36, GPER1, NaV1.2, was present HNSCC, anti-estrogens could be used effective therapeutic approach.

Язык: Английский

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