Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia DOI Creative Commons
Yifan Bu, Songzhe Li, Ting Ye

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 23, 2025

Objective This study aims to elucidate the mitigating effects of volatile oil Acori tatarinowii rhizoma (ATR) on dementia, in order provide a reference for future research and applications ATR field dementia. Materials methods A search strategy was developed using terms such as “Acori rhizoma,” “Acorus Schott,” “Asarone,” “Dementia.” The literature conducted PubMed, Web Science, Google Scholar, studies not meeting inclusion criteria were excluded. summarizes main metabolites, active ingredients, toxicological properties, pharmacokinetic characteristics from with particular focus its potential mechanisms action. Furthermore, highlights limitations existing offers insights into directions. Results mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, neuroinflammation, alleviating vascular risk factors. Conclusion multi-pathway pharmacological are well-aligned complex progression, highlighting significant therapeutic anti-dementia applications. provides new perspectives development more effective drugs. Nonetheless, further rigorous high-quality preclinical clinical investigations required address key issues, chemical characterization ATR, synergistic among toxicity profiles, definitive efficacy.

Язык: Английский

Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia DOI Creative Commons
Yifan Bu, Songzhe Li, Ting Ye

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 23, 2025

Objective This study aims to elucidate the mitigating effects of volatile oil Acori tatarinowii rhizoma (ATR) on dementia, in order provide a reference for future research and applications ATR field dementia. Materials methods A search strategy was developed using terms such as “Acori rhizoma,” “Acorus Schott,” “Asarone,” “Dementia.” The literature conducted PubMed, Web Science, Google Scholar, studies not meeting inclusion criteria were excluded. summarizes main metabolites, active ingredients, toxicological properties, pharmacokinetic characteristics from with particular focus its potential mechanisms action. Furthermore, highlights limitations existing offers insights into directions. Results mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, neuroinflammation, alleviating vascular risk factors. Conclusion multi-pathway pharmacological are well-aligned complex progression, highlighting significant therapeutic anti-dementia applications. provides new perspectives development more effective drugs. Nonetheless, further rigorous high-quality preclinical clinical investigations required address key issues, chemical characterization ATR, synergistic among toxicity profiles, definitive efficacy.

Язык: Английский

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