Early Intervention With Boiogito to Suppress Knee Osteoarthritis Progression: An Experimental Approach Using a Medial Meniscus Instability Rat Model

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

Background Knee osteoarthritis (KOA) is a prevalent and chronic condition characterized by swelling, pain, limited range of motion the knee due to degenerative changes in joint structures, leading impairment performing daily activities. Although conservative treatments, such as exercise therapy nonsteroidal anti-inflammatory drugs are employed, there few effective therapeutic options for preventing disease progression. During early KOA, osteoclast proliferation subchondral bone, disruption cartilage homeostasis, elevation matrix metalloproteinase-13 (MMP-13) levels, reduction tissue inhibitors metalloproteinase-1 (TIMP-1) levels. Boiogito (BOT), which traditional Japanese medicinal formula, attenuates KOA progression, however, its effects when administered after progression remain unclear. This study aimed assess efficacy BOT rat model focusing on motor function, bone turnover, degradation relation timing administration. Methods A was created destabilizing medial meniscus (DMM). Rats were divided into Sham, DMM, DMM + (0w, immediately post-surgery), (3w, 3 weeks post-surgery) groups. included diet at 1% (w/w). Motor function evaluated biweekly treadmill running test, while structural assessed measuring extrusion ratio (MMER) using computed tomography (CT). Histological immunohistochemical analyses conducted evaluate degeneration via Osteoarthritis Research Society International (OARSI) score, numbers through tartrate-resistant acid phosphatase (TRAP) staining, MMP-13/TIMP-1 ratios articular cartilage. Results Treadmill testing revealed that (0w) had significantly higher speeds compared with (3w) In all groups underwent surgery, MMER not different. assessments showed group lower OARSI scores reduced group. Immunohistochemical analysis significant MMP-13 expression group, whereas intervention. Conclusion Early administration preserving reducing mitigating degradation. These findings highlight importance intervention achieve optimal outcomes KOA.

Язык: Английский

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Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis

Nutrients, Год журнала: 2025, Номер 17(3), С. 447 - 447

Опубликована: Янв. 26, 2025

Background: Vitamin D is beneficial for musculoskeletal health. Although low levels of vitamin are linked to increased pain in knee osteoarthritis (OA), their association with functionality remains understudied. Objective: This study aimed investigate the between deficiency and functional status elderly individuals OA explore potential correlation plasma tumor necrosis factor alpha (TNF-α) interleukin-6 (IL-6). Methods: The included older adults (≥60 years) from an ageing study, encompassing 105 patients 152 controls. diagnosis was confirmed radiographically, WOMAC questionnaire assessed impairment these patients. Blood samples were collected measure 25(OH) by chemiluminescence TNF-α IL-6 ELISA. Results: Patients insufficiency/deficiency exhibited more severe cases compared those normal (p = 0.04). inversely correlated OA, according Index (global: rS −0.25, p 0.01; pain: −0.21, 0.03). Moreover, showed significantly higher < 0.05, Mann−Whitney test). Conclusions: Reduced associated hip osteoarthritis, pain, greater impairment, elevated serum IL-6. Further research required elucidate mechanisms underlying influence on evaluate benefits supplementation mitigating disease symptoms progression.

Язык: Английский

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Progress of Research on Chinese Medicine Intervention in Ferroptosis for Osteoarthritis

Journal of Contemporary Medical Practice, Год журнала: 2025, Номер 7(1), С. 157 - 162

Опубликована: Янв. 31, 2025

Osteoarthritis is a common chronic joint disease that brings great pain and life burden to patients. In recent years, ferroptosis, novel mode of programmed cell death, has gradually gained attention in the pathogenesis osteoarthritis. As traditional treatment method, Chinese medicine advantages multi-targeting overall regulation regulating ferroptosis This review discusses mechanisms TCM ferroptosis-related signaling pathways, anti-oxidative stress, inhibition inflammatory responses, key regulators regulatory pathways osteoarthritis, comprehends current status research on targeting active ingredients inhibit so as provide reference for mechanism treating osteoarthritis development drugs.

Язык: Английский

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Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620

Опубликована: Фев. 1, 2025

Язык: Английский

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Proposal for Diet Supplementation to Prevent Knee Osteoarthritis in Female Soccer Players

Dietetics, Год журнала: 2025, Номер 4(1), С. 8 - 8

Опубликована: Фев. 20, 2025

Soccer is a widely practiced and highly mediatic sport discipline. For this reason, the incidence of injuries associated with game an active area research. High-impact actions occur during game, affecting knee joint resulting in osteoarthritis. In line, osteoarthritis results from mechanical biological stress due to lesions that are not adequately repaired, inflammatory process. This occurs because degradation extracellular matrix predominates over synthesis by chondrocytes. Therefore, soccer players, traumatic actions, displaying degenerative evolution. Osteoarthritis up 32% male 3 times more than general population. On other hand, female players main target population suffer osteoarthritis, higher significant observed compared men. context, certain diet supplements have instrumental potential prevention and/or treatment aim narrative review present possible research lines implement treatments for players.

Язык: Английский

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Integrating network pharmacology, molecular docking, and experimental verification to demonstrate that Jiawei Duhuo Parasitic Decoction treated osteoarthritis by inhibiting PTGS2 expression

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100601 - 100601

Опубликована: Март 1, 2025

Язык: Английский

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Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain

Frontiers in Veterinary Science, Год журнала: 2025, Номер 12

Опубликована: Март 19, 2025

Background Accelerometry can be used to measure physical activity and is a validated objective for evaluating the impact of osteoarthritis (OA) pain in companion animals. However, several factors other than OA affect dogs, relatively little understood about their influence. Functional linear modeling (FLM) an approach analyzing visualizing high-frequency longitudinal data such as assess influence on patterns. This study aimed use FLM investigate effect various patterns cohort dogs with pain. Methods Ninety-nine client-owned radiographic clinical evidence were fitted collar-based monitor (Actigraph GT3X). Average vector magnitudes recorded once per minute over 7 days averaged create 24-h, per-minute profiles each dog. Demographic information, owner completed Clinical Metrology Instruments (Liverpool Osteoarthritis Dogs Canine Brief Pain Inventory), veterinary examination findings (joint pain, muscle atrophy) collected. Data analyzed using custom R package evaluate factor 24-h activity. Results At times peak within period, hindlimb higher age, Instrument scores, joint greater Body Condition Score atrophy all had decreased profiles. only statistically significant effects Conclusions relevance Several Understanding what how will help refine usage outcome studies.

Язык: Английский

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Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 27, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of ECM and cartilage degeneration. Articular maintained chondrocytes, which secrete ECM, making stability these cells crucial for function. Research has shown that in later stages OA, cavities form, indicating decline chondrocyte Chondrocyte death considered central feature Apoptosis, form programmed cell death, plays key role this process. While controlled apoptosis helps remove damaged chondrocytes protects from injury, excessive disrupts balance microenvironment accelerates OA progression. Therefore, regulating may offer novel approach preventing treating This review examines pathways, interaction between regulatory factors apoptosis, analyzes current drug interventions targeting both preclinical clinical studies. It also discusses challenges outlines future research directions to guide upcoming

Язык: Английский

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Identification and experimental verification of biomarkers related to butyrate metabolism in osteoarthritis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 7, 2025

Abstract Butyrate plays a crucial role in osteoarthritis (OA) development. However, the relationship between butyrate metabolism-related genes (BMRGs) and OA remains unclear. This study investigates potential correlation BMRGs using OA-related datasets (GSE55235, GSE12021 GSE143514). Differential expression analysis identified 38 differentially expressed (DE-BMRGs) from overlap of 782 (DEGs) 385 GSE55235. Enrichment indicated that these DE-BMRGs were tightly associated with cell proliferation, differentiation, apoptosis, which are key processes pathogenesis. Six candidate biomarkers (IL1B, IGF1, CXCL8, PTGS2, SERPINE1, MMP9) through two machine-learning algorithms. IL1B, PTGS2 upregulated controls, exhibiting consistent patterns across validation datasets. Gene set enrichment (GSEA) revealed dysregulated lead to abnormal proliferation contributing progression. Furthermore, significant differences immune infiltration—particularly activated resting mast cells—along correlations regulatory factors (CD86, CXCL12, TNFSF9, IL6), highlighted therapeutic targets. Quantitative RT-PCR further confirmed elevated CXCL8 control group. identifies as linked metabolism, offering theoretical foundation strategies.

Язык: Английский

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Efficacy of Lavender Oil as an Adjunctive Treatment for Patients with Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of Pain & Palliative Care Pharmacotherapy, Год журнала: 2025, Номер unknown, С. 1 - 8

Опубликована: Апрель 7, 2025

Patients with knee osteoarthritis (OA) experience decline in social and physical abilities. Lavender is a promising option. To determine the clinical efficacy of lavender oil comparison Piroxicam gel (PG) for treatment OA. A double-blind trial 90 patients utilized random blocks to divide them into three groups including group, PG control group comparison. The Visual Analogue Scale (VAS) Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) were used measure aspects osteoarthritis, particularly function, pain, stiffness. Control had no change VAS pain scores. reduced scores after one month, but remained unchanged two months. exhibited significant reduction from 5.37 ± 0.68 3.00 0.64, while decreased score 5.45 0.98 3.62 1.26 (p < 0.001). There was difference between groups. Altogether, has similar effect as on severity function recommended an effective natural therapeutic agent safe complementary

Язык: Английский

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