Breast cancer is a threatening scenario resulting from the development of endometriosis and benign breast disease overlap syndrome: literature review

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2025, Номер 21(2), С. 206 - 214

Опубликована: Апрель 1, 2025

Background. According to the National Cancer Registry of Ukraine, mortality from breast cancer (BC) continues be at first places in structure oncological pathology among female population. The overlap syndrome genital endometriosis (GE) and benign disease (BBD) can play a significant role development BC. purpose: using data modern literature sources, consider GE BBD as precancerous pattern BC outline possible steps solve problem. Materials methods. search selection publications was carried out PubMed Google Scholar databases following terms: endometriosis, disease, mastopathy, fibrocystic dysplasia, mastalgia, cancer, hormone therapy. Results. A convincing link between has been established fertile women: prevalence patients with is 36–38 %. Pilot clinical studies have confirmed that women who received dienogest dose 20 mg/day orally for 24 weeks, decrease size (p < 0.023) regression mastopathic changes were observed when assessing effect progestogen on ultrasound. slight = 0.089) maximum diameter ducts observed. At stages increased risk BC, complex pathogenetic matrix formed, processes which are often not linear, but occur parallel, demonstrating diversity unpredictability biological events. high percentage confirms idea unity origin pathological target organs synchronous hyperplastic them. Conclusions. It advisable diseases generalized process reproductive system, develop single therapeutic tactics gynecological combined diseases. BBD, proven factor requires responsible coordinated teamwork endocrinologists, mammologists obstetricians-gynecologists, designed create necessary conditions improvement effectiveness near future an algorithm monitoring will logical justified step, because early diagnosis provides better treatment results increase quality life patients.

Язык: Английский

Quality of life of endometriosis patients: focus on pain syndrome and neurological disorders

INTERNATIONAL NEUROLOGICAL JOURNAL, Год журнала: 2025, Номер 21(2), С. 130 - 138

Опубликована: Апрель 24, 2025

Background. Endometriosis has a significant impact on the quality of life patients, as it is source debilitating pain syndrome, leading to depression, anxiety and sleep disorders. Therefore, studying possibilities effective treatment this disease assessing indicators patients relevant clinical task. The purpose was investigate in with endometriosis using assessment index, presence intensity well neurological disorders dynamics. Materials methods. One hundred twenty genital aged 19 44 years were divided into 2 study groups: one group, hormone therapy prescribed after laparoscopic removal endometrioma, another — peptide immunocorrection. During monitoring, index assessed, effect dynamics regression symptoms its consequences analyzed. Results. Before start treatment, at relatively low level: 41.0 ± 4.8 points group 1 2. In 1, reached maximum 6 months surgery 77.0 5.5 points, which 75.0 % higher compared baseline. 2, similar an increase observed, end observation period 84.0 3.9 exceeding baseline by 104.9 %. both groups throughout entire we observed decrease gradual number complaining insomnia, depressive anxiety. Conclusions. Surgical endometriosis, prescription restoration immune homeostasis involved organs are components comprehensive management category patients. Reducing chronic pain, subsequently elimination, inevitably improves overall condition their life.

Язык: Английский