Copper-Catalyzed Decarboxylative Phosphorylation of Coumarin-3-carboxylic Acids
Rajnikant N. Ghoghari,
A. Patel,
Parth P. Patel
и другие.
Synlett,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
We
report
a
novel,
efficient,
one-pot,
copper-catalyzed,
decarboxylative
strategy
for
the
cross-coupling
of
coumarin
3-carboxylic
acids
with
H-phosphonates.
The
approach
involves
decarboxylation
followed
by
phosphonation
through
radical
pathway,
and
uses
an
inexpensive
copper
catalyst.
Optimizations
were
carried
out
using
various
catalysts,
oxidants,
solvents.
reaction
is
highly
effective,
broad
functional-group
tolerance,
affords
good
to
excellent
yields.
This
transformation
provides
versatile
useful
synthetic
pathway
construction
bioactive
scaffolds
valuable
C–P
bonds.
Язык: Английский
Tf2O/DMSO-Promoted Umpolung Phosphorylation for C(sp2)–P or C(sp3)–P Bond Formation
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
We
have
developed
an
umpolung
method
utilizing
the
Tf2O/DMSO-based
system
for
C(sp2)-P
bond
or
C(sp3)-P
formation.
This
employs
both
P(O)-H
and
P(O)-OH
compounds
as
phosphorus
sources
demonstrates
excellent
compatibility
with
a
wide
range
of
Grignard
reagents.
Without
requirement
precious
transition
metals
additives,
this
one-pot
protocol
provides
practical
efficient
synthetic
pathway
to
variety
aryl
alkyl
phosphine
oxides.
The
broad
substrate
scope
diverse
applications
highlight
utility
method.
Язык: Английский