Mussel‐Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июнь 23, 2024

Inadequate osseointegration at the interface is a key factor in orthopedic implant failure. Mechanistically, traditional interfaces fail to precisely match natural bone regeneration processes vivo. In this study, novel biomimetic coating on titanium substrates (DPA-Co/GFO) through mussel adhesion-mediated ion coordination and molecular clicking strategy engineered. vivo vitro results confirm that exhibits excellent biocompatibility effectively promotes angiogenesis osteogenesis. Crucially, targets integrin α2β1 receptor promote M2 macrophage polarization achieves synergistic effect between immunomodulation vascularized regeneration, thereby maximizing interface. Mechanical push-out tests reveal pull-out strength DPA-Co/GFO group markedly greater than control (79.04 ± 3.20 N vs 31.47 1.87 N, P < 0.01) even surpasses sham 63.09 8.52 0.01). summary, developed study matches process of vivo, enhancing interface-related showing considerable potential for clinical translation applications.

Язык: Английский

---

“Disguise strategy” to bacteria: A multifunctional hydrogel with bacteria-targeting and photothermal conversion properties for the repair of infectious bone defects

Bioactive Materials, Год журнала: 2025, Номер 47, С. 343 - 360

Опубликована: Фев. 12, 2025

Язык: Английский

---

Osteogenic and Antibacterial Enhancement by Alloying Design and Microstructural Modification of Additively Manufactured Biodegradable Metals

Опубликована: Янв. 1, 2025

Язык: Английский

---

Orthopedic Implants: Necessity of Coating, Their Advantages, and Challenges

Journal of Bio- and Tribo-Corrosion, Год журнала: 2025, Номер 11(2)

Опубликована: Март 26, 2025

Язык: Английский

---

Primary diaphyseal tuberculosis of the tibia, presenting as a pathological fracture – A case report

Trauma Case Reports, Год журнала: 2025, Номер unknown, С. 101161 - 101161

Опубликована: Апрель 1, 2025

Язык: Английский

---

Coated Bacteria: Advanced Living Materials for Microbial Therapy

Accounts of Materials Research, Год журнала: 2024, Номер 5(7), С. 872 - 883

Опубликована: Июнь 24, 2024

ConspectusLiving materials represent an emerging and innovative concept at the forefronts of science due to distinctive living characteristics. Living organisms, such as microorganisms, plant cells, mammalian have been used major elements for fabrication materials. Given favorable features including reproductivity, genetic modifiability, adaptability, cultivability, bacteria received increasing attention development engineered Particularly, owing inherent abilities target colonize specific in vivo sites, activate immune responses, inhibit pathogens, play key roles maintaining human health currently widely exploited preparation therapeutic agents. However, caused by innate immunogenicity, metabolic activity, movability, use bacteria-based applications often suffers from poor biosafety insufficient bioavailability, inevitably resulting low treatment efficacy. In order address these challenges, extensive efforts invested designing engineering various advanced generate superior agents using modification surface decoration.In this Account, we summarize recent advances our group with a focus on coating material microbial therapy. First, present brief introduction existing nature that possess characteristics reproduction, biosynthesis, self-healing, self-organization, self-adaption, environment responsiveness, particular emphasis advantages composed Second, elaborate current challenges then showcase strategies prepare bacterial therapeutics individual bacteria. Three types are included Account: (1) physical strategy coat eukaryotic cell membranes red blood cells yeast mechanical extrusion; (2) chemical wrap synthetic coatings interfacial self-assembly mineralization; (3) biological encapsulate self-secreted biofilms apoptosis bodies through external stimulations. We highlight coated can be endowed wide range coating-derived exogenous functions enumerate their appealing reduced clearance, increased improved safety, preferential colonization vivo. Third, shift potential treating diseases, especially different cancer intestinal inflammations. Lastly, discuss remaining need addressed further clinic practice outlooks preparing next-generation well future bench bedside translation. anticipate Account offer valuable insights generation therapy encourage ideas new initiatives expand preventing diseases.

Язык: Английский

---

Basic research is the foundation and driving force for clinical translation

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 45, С. A1 - A2

Опубликована: Март 1, 2024

Язык: Английский

---

Multidisciplinary approach and host optimization for fracture-related infection management

Injury, Год журнала: 2024, Номер 55, С. 111899 - 111899

Опубликована: Окт. 31, 2024

Язык: Английский

---

Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology

Nanomaterials, Год журнала: 2024, Номер 14(23), С. 1876 - 1876

Опубликована: Ноя. 22, 2024

3D-printed microporous titanium scaffolds enjoy good biointegration with the residuum's soft and bone tissues, they promote excellent biomechanical properties in attached prostheses. Implant-associated infection, however, remains a major clinical challenge. Silver-based implant coatings can potentially reduce bacterial growth inhibit biofilm formation, thereby reducing risk of periprosthetic infections. In current study, 1-µm thick silver coating was prepared on surface alloy physical vapor deposition (PVD), final content 1.00 ± 02 mg/cm

Язык: Английский

---

A Cross-Linked Coating Loaded with Antimicrobial Peptides for Corrosion Control, Early Antibacterial, and Sequential Osteogenic Promotion on a Magnesium Alloy as Orthopedic Implants

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

---