Clinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 3, 2025
The
purpose
of
this
study
was
to
investigate
the
clinical
efficacy
antibiotic-loaded
bone
cement
(ALBC)
combined
with
Negative
pressure
wound
therapy
(NPWT)
aspiration
technique
in
treatment
multidrug-resistant
diabetic
foot
ulcers
(MDRO-DFUs).
A
retrospective
analysis
data
80
patients
MDROs-DFU
who
were
used
Vacuum
sealing
drainage
(VSD)
as
NPWT
excipient
and
met
inclusion
criteria
from
January
2019
2024
at
our
hospital.
Patients
divided
into
an
experimental
group
a
control
group,
40
cases
each.
received
conventional
treatment,
routine
debridement,
while
ALBC
addition
plan
group.
Measurements
blood
inflammatory
indicators,
hemodynamic
bacterial
clearance
time,
healing
hospital
stay
taken
before
after
for
both
groups.
Inflammatory
indexes,
Vascular
endothelial
growth
factor(VEGF),
internal
diameter
dorsalis
pedis
arteriosus
groups
significantly
better
than
those
improvement
more
obvious
that
group;
had
shorter
time
trauma
turnover,
trauma,
hospitalization
compared
(P<0.05).
Язык: Английский
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 1755 - 1772
Опубликована: Фев. 1, 2025
Purpose:
Microinjury
can
trigger
in
situ
tissue
repair.
Bone
transport
consists
of
continuous
microinjuries/microfracture
and
induces
bone
formation
angiogenesis.
Tibial
cortex
transverse
(TTT)
was
found
to
promote
angiogenesis
at
the
foot
healing
diabetic
ulcers
(DFUs).
However,
underlying
mechanism
remains
largely
unknown.
Methods:
We
divided
72
Sprague-Dawley
rats
with
DFUs
into
control,
sham,
TTT
groups.
Wound
measurement
histology
were
performed
evaluate
wound
processes.
Enzyme-linked
immunosorbent
assay,
flow
cytometry,
immunohistochemistry,
Western
Blot
used
assess
activity
endothelial
progenitor
cells
(EPCs)
Ras/Raf/MEK/ERK
signaling
pathway.
Results:
accelerated
healing,
improved
epidermal
continuity,
increased
dermal
thickness
group
than
control
sham
Higher
levels
serum
TGF-β
1,
PDGF-BB,
VEGF
detected
group.
These
changes
parallel
expression
wounds
frequency
EPCs
both
marrow
peripheral
circulation,
which
implied
that
secreted
proliferation
migration
wounds.
The
CD31
+
cells,
SMA-α
pathway
higher
Conclusion:
findings
showed
enhanced
production
growth
factors
turn
activated
EPC
through
pathway,
ultimately
contributing
DFU
healing.
Based
on
these
findings,
we
proposed
a
theory
remote
microinjuries
repair
target
tissues
(ie,
microinjury-induced
repair,
MIRR).
Future
studies
are
needed
validate
this
theory.
Keywords:
microinjury,
transport,
tibial
ulcer,
Язык: Английский
Efficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels
Diabetology & Metabolic Syndrome,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июль 9, 2024
Abstract
Objective
Diabetic
foot
ulcer
(DFU)
is
a
common
and
debilitating
complication
of
diabetes
that
associated
with
an
increased
risk
lower-limb
amputation
reduced
life
expectancy.
Tibial
cortex
transverse
transport
(TTT)
has
become
newly
alternative
surgical
method
to
facilitate
healing
prevent
lower
limb
amputation.
Herein,
we
investigated
the
efficacy
TTT
in
treating
DFU
changes
serum
omentin-1
irisin
levels.
Methods
This
study
prospectively
recruited
52
consecutive
patients
who
were
treated
TTT.
The
follow-up
was
performed
weekly
during
first
12
weeks
postoperatively
every
3
months
until
1
year
after
levels
vascular
endothelial
growth
factor
(VEGF),
omentin-1,
undergoing
determined
by
ELISA
methods
on
preoperative
1st
day,
postoperative
2nd
week
4th
week.
Results
wound
rate
92.3%
(48/52)
at
1-year
follow-up.
visual
analog
scale
(VAS)
pain
scores
showed
significant
reduction
(
p
<
0.001).
dorsal
skin
temperature,
ankle
brachial
index,
blood
flow
significantly
VEGF,
notably
elevated
compared
day
also
higher
than
Conclusion
could
promote
reduce
amputation,
demonstrating
promising
clinical
benefits
treatment
DFU.
Increased
expressions
proangiogenic
factors
including
noted
early
stage
TTT,
which
may
provide
new
mechanism
promoting
heal.
Язык: Английский
Basic research is the foundation and driving force for clinical translation
Journal of Orthopaedic Translation,
Год журнала:
2024,
Номер
45, С. A1 - A2
Опубликована: Март 1, 2024
Язык: Английский
Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)
Experimental and Therapeutic Medicine,
Год журнала:
2024,
Номер
28(6)
Опубликована: Окт. 16, 2024
Stroke,
including
hemorrhagic
stroke
and
ischemic
stroke,
is
a
common
disease
of
the
central
nervous
system.
It
characterized
by
high
mortality
disability
rate
closely
associated
with
atherosclerosis,
hypertension
hyperglycemia,
atrial
fibrillation
unhealthy
living
habits.
The
continuous
development
surgery
medications
has
decreased
patients
greatly
improved
prognosis.
At
present,
direction
clinical
treatment
research
gradually
shifted
to
repair
nerve
function
after
stroke.
Osteopontin
(OPN)
widely
distributed
extracellular
matrix
protein.
Due
its
structural
characteristics,
OPN
can
be
cut
modified
into
terminal
fragments
different
functions,
which
play
roles
in
various
pathophysiological
processes,
such
as
formation
tumors,
inflammation
autoimmune
diseases.
also
become
potential
diagnostic
therapeutic
marker.
In
order
comprehensively
analyze
specific
role
relationship
stroke-related
diseases,
following
key
words
were
used:
'Osteopontin,
atherosis,
neuroplasticity,
neural
repair'.
PubMed,
Web
Science
Cochrane
articles
related
searched
summarized.
present
review
describes
structure,
isoforms,
functions
mechanism,
association
occurrence
diseases
was
explored.
Язык: Английский