Recent Progress in Alginate-based Nanocomposites for Bone Tissue Engineering Applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114570 - 114570

Опубликована: Фев. 18, 2025

Язык: Английский

Osteomimix: A Multidimensional Biomimetic Cascade Strategy for Bone Defect Repair

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by formation process, multidimensional cascade strategy is developed replicating biomineralization cascade, emulating hierarchical structure bone, and biomimicking its biological functions for efficient regeneration. This involves photocrosslinking sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create self-mineralizing hydrogel. The hydrogel then integrated either naturally derived or synthetic oriented bulk scaffolds. resulting composite, named Osteomimix, provides excellent mechanical support can be customized irregular using CAD/CAM technology. Through vitro vivo studies, this work finds that Osteomimix exhibits spontaneous situ cell-free environment, while modulating immune responses promoting vascularized cell-dependent manner. Built on bone-specific insights, achieves biomimicry across temporal, spatial, functional dimensions, facilitating seamless integration artificial constructs natural tissue dynamics.

Язык: Английский

Addressing musculoskeletal disorders through new treatment strategies

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 48, С. A1 - A2

Опубликована: Сен. 1, 2024

Язык: Английский