Treatment of early hypertensive renal damage with Quanduzhong capsules: two case reports

Journal of Hypertension, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Background: Hypertensive nephropathy is increasingly prevalent and a leading cause of end-stage renal disease. Current treatment strategies for hypertensive focus on blood pressure control reducing urinary albumin. However, the use angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) medications carries risks, including potential decrease in glomerular filtration rate (GFR). This report aims to assess clinical effectiveness Quanduzhong capsules (QDZCs) early-stage kidney damage, contributing evidence base their traditional Chinese medicine hypertension treatment. Methods: The patients, two middle-aged gentlemen with over decade medical history, were currently early phase grade 1 hypertension. Notably, readings consistently exceeded normal parameters. Furthermore, they exhibited signs microalbuminuria proteinuria presentations. Based these symptoms, received diagnosis specifically at stage. Results: After admission, patients took QDZCs medication method was: 2 times day, 3 each time. results showed that case reduced within 12 weeks after taking medicine, average 24-h was also reduced. Case experienced slight creatinine clearance treatment, but difference not significant. During 12-week follow-up period, there no significant abnormalities serum creatinine, urea nitrogen, clearance, estimated rate. Conclusion: shows capsule can lower improve symptoms may provide promising option management damage. preliminary larger, controlled studies are needed determine its efficacy advantages.

Язык: Английский

Recent discoveries of oral substances’ effects on osteoporosis treatment - novel markers and pathways

Quality in Sport, Год журнала: 2024, Номер 19, С. 54329 - 54329

Опубликована: Авг. 30, 2024

The search for optimal osteoporosis treatments continues, as the medications currently used in clinical therapy carry a risk of rare but acute side effects. New knowledge about etiopathogenetic pathways and biomarkers enabled exact examination various oral substances, often previously recognised their positive impact on bone mass growth. A cross-section novel reports from this year applications many orally administered substances is presented. Diet, gut microbiota aspect, functional food, diabetes drug – empagliflozin variety known Chinese traditional medicine are now characterized context possible mechanism treating or preventing osteoporosis. progress density quality-regulating recognition led to finding multiple with favorable mediation properties. precise diagnosis substances' working mechanisms approves potential use new formulations treatments. Presently only diet supplementation, administrated antiosteoporotic core ingredients modernized medications, provided presumptive adverse effects ruled out.

Язык: Английский

Hierarchical Porous Microspheres-Assisted Serum Metabolic Profile for the Early Diagnosis and Surveillance of Postmenopausal Osteoporosis

Analytical Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

With the aging global population, incidence of osteoporosis (OP) is increasing, putting more individuals at risk. Since postmenopausal (PMOP) often remains asymptomatic until a fracture occurs, making early clinical diagnosis PMOP particularly challenging. In this work, AuNPs-anchored hierarchical porous ZrO

Язык: Английский