Combatting BPA‐Induced Neurotoxicity With Purple Carrot Extract (Daucus carota): Modulation of Key Neurotransmitters and Cellular Pathways in Albino Rats DOI Creative Commons
Amira M. Elmoslemany,

Mai Hussein Abd-Elfatah,

Wesam Mohammed Abd Elrahman

и другие.

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Ethnopharmacological Relevance: Bisphenol A (BPA) is a widely used chemical, particularly in producing epoxy resins and polycarbonate plastics, which can contaminate food water sources. Even low levels of BPA exposure have been associated with negative impacts on neural development, leading to neurotoxicity. Purple carrots, known for their health‐promoting properties, are rich bioactive compounds such as polyphenols. Materials Methods: This study aimed evaluate the neuroprotective effects purple carrot extract mitigating BPA‐induced neurotoxicity albino rats. Forty rats were divided into four groups: Group I (control) received standard diet. II (BPA group) was orally administered 50 mg/kg body weight dissolved 1 mL olive oil daily 30 days. III 400 along daily. IV 800 daily, following same 30‐day oral administration protocol. Results: The results showed that treatment increased serum critical neurotransmitters, including serotonin, dopamine, acetylcholine, acetylcholineesterase, gamma‐aminobutyric acid (GABA). Additionally, brain tissue analysis revealed elevated activity antioxidant enzymes, catalase (CAT) superoxide dismutase (SOD), response administration. Conversely, significantly reduced malondialdehyde (MDA), α‐tumor necrosis factor (α‐TNF), interleukin‐6 (IL‐6) tissues compared BPA‐only group. These indicate regulates genes related oxidative stress, inflammation, apoptosis dose‐dependent manner during At dose mg/kg, expression like Nrf2 HO‐1 while reducing pro‐apoptotic marker Bax. higher these protective even more pronounced, enhanced neuroprotection through antiapoptotic gene mainly MAPK pathway. Conclusion: demonstrates reduces by enhancing antioxidants, anti‐inflammatory responses, suggesting natural protection against BPA‐related damage.

Язык: Английский

Combatting BPA‐Induced Neurotoxicity With Purple Carrot Extract (Daucus carota): Modulation of Key Neurotransmitters and Cellular Pathways in Albino Rats DOI Creative Commons
Amira M. Elmoslemany,

Mai Hussein Abd-Elfatah,

Wesam Mohammed Abd Elrahman

и другие.

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Ethnopharmacological Relevance: Bisphenol A (BPA) is a widely used chemical, particularly in producing epoxy resins and polycarbonate plastics, which can contaminate food water sources. Even low levels of BPA exposure have been associated with negative impacts on neural development, leading to neurotoxicity. Purple carrots, known for their health‐promoting properties, are rich bioactive compounds such as polyphenols. Materials Methods: This study aimed evaluate the neuroprotective effects purple carrot extract mitigating BPA‐induced neurotoxicity albino rats. Forty rats were divided into four groups: Group I (control) received standard diet. II (BPA group) was orally administered 50 mg/kg body weight dissolved 1 mL olive oil daily 30 days. III 400 along daily. IV 800 daily, following same 30‐day oral administration protocol. Results: The results showed that treatment increased serum critical neurotransmitters, including serotonin, dopamine, acetylcholine, acetylcholineesterase, gamma‐aminobutyric acid (GABA). Additionally, brain tissue analysis revealed elevated activity antioxidant enzymes, catalase (CAT) superoxide dismutase (SOD), response administration. Conversely, significantly reduced malondialdehyde (MDA), α‐tumor necrosis factor (α‐TNF), interleukin‐6 (IL‐6) tissues compared BPA‐only group. These indicate regulates genes related oxidative stress, inflammation, apoptosis dose‐dependent manner during At dose mg/kg, expression like Nrf2 HO‐1 while reducing pro‐apoptotic marker Bax. higher these protective even more pronounced, enhanced neuroprotection through antiapoptotic gene mainly MAPK pathway. Conclusion: demonstrates reduces by enhancing antioxidants, anti‐inflammatory responses, suggesting natural protection against BPA‐related damage.

Язык: Английский

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