Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker DOI Creative Commons

Ruicheng Wu,

Dengxiong Li, Shuxia Zhang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Background The literature on the role of pleomorphic adenoma gene 1 (PLAG1) in malignant tumors is limited. This study aimed to perform pan-cancer analysis PLAG1. Methods expression PLAG1 was analyzed by Human Protein Atlas (HPA). differential and prognosis were based TCGA data. relationship between tumor heterogeneity, stemness immune infiltration investigated. enrichment biological function bladder cancer analyzed. Results increased a variety significantly correlated with patients. Their levels associated key checkpoint genes (CD274, HAVCR2), stimulation factors (CD48, CD27). In cancer, functional indicated that involved epidermal related processes pathways. reduction can inhibit proliferation cells. Conclusions has potential be prognostic marker therapeutic target for patients tumors.

Язык: Английский

Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker DOI Creative Commons

Ruicheng Wu,

Dengxiong Li, Shuxia Zhang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Background The literature on the role of pleomorphic adenoma gene 1 (PLAG1) in malignant tumors is limited. This study aimed to perform pan-cancer analysis PLAG1. Methods expression PLAG1 was analyzed by Human Protein Atlas (HPA). differential and prognosis were based TCGA data. relationship between tumor heterogeneity, stemness immune infiltration investigated. enrichment biological function bladder cancer analyzed. Results increased a variety significantly correlated with patients. Their levels associated key checkpoint genes (CD274, HAVCR2), stimulation factors (CD48, CD27). In cancer, functional indicated that involved epidermal related processes pathways. reduction can inhibit proliferation cells. Conclusions has potential be prognostic marker therapeutic target for patients tumors.

Язык: Английский

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