Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder DOI Creative Commons
Qian Xiao,

Liying Shen,

Haoling He

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 26, 2023

Abstract Background The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. study aimed to assess the alterations neural activity within prefrontal cortex with BPD and investigate relationship cognitive function emotional regulation. Methods This enrolled 50 aged 12–17 years 21 gender age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), testing Stroop Color-Word Test (SCWT) clinical questionnaires such as Borderline Personality Features Scale (BPFS), Difficulties Emotion Regulation (DERS), Ottawa Self-Injury Inventory Childhood Trauma Questionnaire (CTQ). Fractional amplitude low-frequency fluctuations (fALFF) seed-based connectivity (FC) were obtained from rs-fMRI analysis. Correlative analysis was also performed evaluate associations neuroimaging metrics fALFF FC scores questionnaire scores. Results Adolescents showed increased values right inferior frontal gyrus decreased left middle compared HC group (p < 0.05, cluster size ≥ 100, FWE correction). In BPD, reduced associated SCWT-A (reading characters) SCWT-B color). Increased related BPFS, DERS-F Inventory-4C. Additionally, both CTQ-D (emotional neglect) 0.05). exhibited hippocampus, temporal (voxel p 0.001, between hippocampus SCWT-C (cognitive flexibility). Conclusions We observed diverging changes intrinsic cortex, compensatory maintain BPD. addition, indicated by dysfunction, while closely dysregulation. These results that may be one underlying markers symptoms

Язык: Английский

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation DOI Creative Commons
Tingting Zhu, Zixu Wang, Chao Zhou

и другие.

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Сен. 27, 2022

Persistent negative symptoms (PNS) include both primary and secondary that persist after adequate treatment, represent an unmet therapeutic need. Published magnetic resonance imaging (MRI) evidence of structural resting-state functional brain abnormalities in schizophrenia with PNS has been inconsistent. Thus, the purpose this meta-analysis is to identify regions patients compared healthy controls.We systematically searched PubMed, Web Science, Embase for studies based on five research methods, including voxel-based morphometry (VBM), diffusion tensor (DTI), connectivity (FC), amplitude low-frequency fluctuation or fractional (ALFF/fALFF), regional homogeneity (ReHo). Afterward, we conducted a coordinate-based by using activation likelihood estimation algorithm.Twenty-five MRI thirty-two were included meta-analyses. Our analysis revealed presence alterations some bilateral insula, medial frontal gyrus, anterior cingulate left amygdala, superior temporal inferior gyrus middle as well differences precuneus, thalamus, lentiform nucleus, posterior gyrus.Our study suggests are consistently located prefrontal, temporal, limbic subcortical regions, concentrated thalamo-cortical circuits default mode network (DMN). This provides new insights targeted treatment intervention delay further progression symptoms.[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022338669].

Язык: Английский

Процитировано

27
Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder DOI
Qian Xiao,

Liying Shen,

Haoling He

и другие.

European Child & Adolescent Psychiatry, Год журнала: 2024, Номер 33(11), С. 3937 - 3949

Опубликована: Апрель 20, 2024

Язык: Английский

Процитировано

4
Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies DOI Creative Commons
Giuseppe Pierpaolo Merola, Livio Tarchi, Luigi F. Saccaro

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Июнь 4, 2024

Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, bipolar disorder. A pathophysiological understanding intrinsic brain activity underlying psychosis is crucial to improve diagnosis treatment. While a potential continuum along psychotic spectrum has been recently described in neuroimaging studies, especially for what concerns absolute relative amplitude low-frequency fluctuations (ALFF fALFF), these efforts have given heterogeneous results. transdiagnostic meta-analysis ALFF/fALFF patients with compared healthy controls currently lacking. Therefore, this pre-registered systematic review PubMed, Scopus, Embase were searched articles comparing between controls. quantitative synthesis differences (f)ALFF was performed Seed-based d Mapping, adjusting age, sex, duration illness, clinical severity. All results corrected multiple comparisons by Family-Wise Error rates. lower ALFF fALFF detected comparison controls, no specific finding survived correction comparisons. Lack might explain discordant findings highlighted previous literature. Other explanations include methodological issues, lack standardization pre-processing or analytical procedures studies. Future research on should prioritize replicability individual Systematic registration https://osf.io/ , identifier (ycqpz).

Язык: Английский

Процитировано

3
Corticolimbic Structural Deficits in Violent Patients with Schizophrenia DOI Creative Commons

Maria Athanassiou,

Alexandre Dumais, Inès Zouaoui

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(3), С. 224 - 224

Опубликована: Фев. 21, 2025

Background/Objectives: Violent behaviors are uncommon in patients with schizophrenia (Sch), but when present, exacerbate stigma and challenge treatment. The following study aimed to identify the structural abnormalities associated violent Sch by implementing a validated tool specifically designed evaluate psychiatric populations, as well performing region-of-interest neuroimaging analyses, focused on areas commonly neurobiology of violence aggression. Methods: Eighty-three participants were divided into three groups: (Sch+V, n = 34), without (Sch-V, 28), healthy controls (HC, 21). Structural analyses performed across groups assess gray matter volume (GMV) cortical thickness (CT) differences regions previously implicated aggressive behaviors. Results: data revealed significant reductions GMV right amygdala diminished bilateral dorsolateral prefrontal cortices (dlPFC) Sch+V compared Sch-V HCs. Right amygdalar also demonstrated negative correlational trend hostility scores Sch+V. Conclusions: These findings underscore disruptions integrity dlPFC—responsible for inhibitory control—and amygdala—central emotional processing Sch. Future research should aim investigate potential functional interactions at network level gain deeper understanding neurobiological underpinnings this population.

Язык: Английский

Процитировано

0
Voxel-based alterations in spontaneous brain activity among very-late-onset schizophrenia-like psychosis: A preliminary resting-state functional magnetic resonance imaging study DOI
Daoguo Yang, Ping Ji,

Jiaojiao Sun

и другие.

World Journal of Psychiatry, Год журнала: 2025, Номер 15(3)

Опубликована: Фев. 26, 2025

Very late-onset schizophrenia-like psychosis (VLOSLP) is a subtype of schizophrenia spectrum disorders in which individuals experience psychotic symptoms for the first time after age 60. The incidence VLOSLP shows linear relationship with increasing age. However, no studies have reported alterations spontaneous brain activity among patients and their correlation cognitive function clinical symptoms. To explore correlations using resting-state functional magnetic resonance imaging. This study included 33 34 healthy controls. assessment utilized Mini Mental State Examination, Montreal Cognitive Assessment, Repeatable Battery Assessment Neuropsychological Status (RBANS). Clinical characteristic acquisition was performed via Positive Negative Syndrome Scale (PANSS). All participants were scanned imaging, data processed amplitude low-frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity, voxel-mirrored homotopic connectivity (VMHC). group presented decreased values left cuneus, right precuneus, precentral gyrus, paracentral lobule; increased fALFF caudate nucleus; calcarine fissure surrounding cortex (CAL) precuneus; homogeneity putamen; VMHC bilateral CAL, superior temporal cuneus. In group, precuneus negatively correlated Examination score PANSS positive subscale score, CAL RBANS total delayed memory score. changes are concentrated regions, may be associated impairment clinically

Язык: Английский

Процитировано

0
The relationship between cognitive function and cortical thickness in first-episode drug-naive schizophrenia patients with agitation DOI Creative Commons
Qian Liang, Yan Li, Chao Zhou

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 24, 2025

This study aims to explore the relationships between agitation behavior, cognitive function and cortical thickness in first-episode drug-naïve schizophrenia (FESN). A total of 55 male healthy controls (HC) 79 inpatients with FESN were enrolled present study. Whole brain was extracted from T1-weighted MRI using Freesurfer Version 7.4.1 software package. Cognitive evaluated MATRICS Consensus Battery (MCCB). The Positive Negative Syndrome Scale-Excited Component (PANSS-EC) is used divide these into group (FESN+A) non-agitation (FESN+NA). Correlation analysis employed investigate potential associations function. FESN+A had higher Scale (PANSS) score, positive symptom general psychopathology score than FESN+NA group. Both FESN+A/NA groups showed significantly worse performance HC symbol coding, working memory, attention/vigilance, reasoning problem solving, social cognition. performed on memory when comparing Furthermore, left paracalcarine gyrus increased group, compared HC. thicker right posterior cingulate cortex (rPCC) rPCC negatively correlated demonstrated that abnormal may be related behavior patients FESN+A, suggesting a treatment target for impairment schizophrenia.

Язык: Английский

Процитировано

0
Resting-state neural correlates of schizotypy and its predictive effect on bulimic symptoms DOI

Haoyu Guo,

Mingyue Xiao, Wei Li

и другие.

Personality and Individual Differences, Год журнала: 2025, Номер 243, С. 113226 - 113226

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0
Aberrant Functional Connectivity of the Orbitofrontal Cortex Is Associated With Excited Symptoms in First-Episode Drug-Naïve Patients With Schizophrenia DOI Creative Commons

Cong‐Xin Chen,

Jingjing Yao,

Yiding Lv

и другие.

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Июль 28, 2022

Schizophrenia (SZ) is associated with the highest disability rate among serious mental disorders. Excited symptoms are core of SZ, which appear in early stage, followed by other stages disease subsequently. These destructive and more prone to violent attacks, posing a economic burden society. Abnormal spontaneous activity orbitofrontal cortex had been reported be excited patients SZ. However, whether abnormality appears first-episode drug-naïve SZ has still remained elusive.A total 56 27 healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI) positive negative syndrome scale (PANSS). First, differences fractional amplitude low-frequency fluctuations (fALFF) between were examined identify cerebral regions exhibiting abnormal local activity. Based on fALFF results, connectivity analysis was performed determine changes Finally, correlation exciting analyzed.Compared controls, showed significant decrease intrinsic bilateral precentral gyrus, postcentral left cortex. In addition, significantly reduced values several regions, mainly distributed right middle frontal paracentral lobules, median cingulate. Further analyses that as well negatively correlated SZ.Our results indicated important role suggested may valuable predict occurrence symptoms. provide new direction explore

Язык: Английский

Процитировано

7
Dysconnectivity between the anterior insula and the dorsal anterior cingulate cortex during an emotion go/nogo paradigm is associated with aggressive behaviors in male schizophrenia patients DOI
Alexandra Fortier, Alexandre Dumais,

Maria Athanassiou

и другие.

Psychiatry Research Neuroimaging, Год журнала: 2022, Номер 328, С. 111579 - 111579

Опубликована: Ноя. 30, 2022

Язык: Английский

Процитировано

7
Neurocognitive Suicide and Homicide Markers in Patients with Schizophrenia Spectrum Disorders: A Systematic Review DOI Creative Commons
Mario Tomé-Fernández,

Marina Berbegal-Bernabeu,

Miriam Sánchez‐SanSegundo

и другие.

Behavioral Sciences, Год журнала: 2023, Номер 13(6), С. 446 - 446

Опубликована: Май 26, 2023

Suicide and homicide are considered important problems in public health. This study aims to identify the cognitive performance of suicidal homicidal behaviors people with schizophrenia spectrum disorders, as well examining whether there shared neuropsychological mechanisms. A systematic review recent literature was carried out from September 2012 June 2022 using Medline (via PubMed), Scopus, Embase, Cochrane databases. Among 870 studies initially identified, 23 were finally selected (15 related 8 behaviors). The results evidenced a relationship between impairment behavior; meanwhile, for behaviors, no consistent found. High seems act protective factor against violent behavior but not indeed, it can even risk behavior. To date, is insufficient evidence that neurocognitive mechanisms exist. However, processing speed visual memory seem be affected presence both behaviors.

Язык: Английский

Процитировано

3