Gut Microbiota: A Modulator and Therapeutic Target for Chronic Pain

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Язык: Английский

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L-methionine and the L-type Ca2+ channel agonist BAY K 8644 collaboratively contribute to the reduction of depressive-like behavior in mice

Frontiers in Neural Circuits, Год журнала: 2024, Номер 18

Опубликована: Авг. 29, 2024

The L-type Ca 2+ channel (LTCC, also known as Cav1,2) is involved in the regulation of key neuronal functions, such dendritic information integration, cell survival, and gene expression. Clinical studies have shown an association between calcium channels onset depression, although precise mechanisms remain unclear. development depression results from a combination environmental genetic factors. DNA methylation, significant epigenetic modification, plays regulatory role pathogenesis psychiatric disorders posttraumatic stress disorder (PTSD), autism. In our study, we observed reduced Dnmt3a expression levels hippocampal DG region mice with LPS-induced compared to control mice. antidepressant Venlafaxine was able increase levels. Conversely, Bay K 8644, agonist channel, partially ameliorated depression-like behaviors but did not elevate Furthermore, when manipulated methylation during 8644 intervention models, found that enhancing could improve depression/anxiety-like behaviors, while inhibiting exacerbated anxiety-like combined use BAY L-methionine can better depressive-like behavior. These findings indicate by further research needed elucidate interactions channels.

Язык: Английский

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Depression: The Vagus Nerve and Gut-Brain Axis

Опубликована: Янв. 1, 2024

Язык: Английский

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