Functional near-infrared spectroscopy (fNIRS) in patients with major depressive disorder, generalized anxiety disorder and their comorbidity: comparison with healthy controls
Asian Journal of Psychiatry,
Год журнала:
2025,
Номер
105, С. 104382 - 104382
Опубликована: Фев. 7, 2025
Язык: Английский
Changes in degree centrality and its associated genes: A longitudinal study of patients with schizophrenia undergoing pharmacological treatment
Schizophrenia Research,
Год журнала:
2025,
Номер
277, С. 130 - 139
Опубликована: Март 1, 2025
The
role
of
degree
centrality
(DC)
in
schizophrenia
(SCZ),
its
trajectory
following
pharmacological
treatment,
and
potential
as
a
prognostic
biomarker
genetic
mechanism
remain
unclear.
We
recruited
51
healthy
controls
(HC)
56
patients
with
SCZ.
Additionally,
the
SCZ
underwent
three
months
antipsychotic
medication
treatment.
collected
resting-state
functional
magnetic
resonance
imaging
data,
clinical
variables,
conducted
analyses
using
support
vector
machines,
regression,
gene
expression
correlation
analysis.
Our
study
revealed
that
had
generally
reduced
DC
values
cerebral
cortex
compared
to
HC
at
baseline,
increased
observed
left
occipital
gyrus.
After
exhibited
significant
decrease
fusiform
gyrus
an
increase
inferior
parietal
Variations
were
associated
multiple
genes,
primarily
enriched
molecular
functions.
Changes
right
occipital/fusiform
calcarine/middle
may
serve
neuroimaging
markers
differentiate
between
patients.
middle/postcentral
could
be
used
predict
treatment
outcomes.
Transcriptome-neuroimaging
spatial
analysis
provides
valuable
insights
into
neurobiological
mechanisms
underlying
pathology.
Язык: Английский
Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(4)
Опубликована: Март 25, 2025
BACKGROUND
Major
depressive
disorder
(MDD)
with
comorbid
anxiety
is
an
intricate
psychiatric
condition,
but
limited
research
available
on
the
degree
centrality
(DC)
between
anxious
MDD
and
nonanxious
patients.
AIM
To
examine
changes
in
DC
values
their
use
as
neuroimaging
biomarkers
non-anxious
METHODS
We
examined
23
patients,
30
28
healthy
controls
(HCs)
using
for
data
analysis.
RESULTS
Compared
HCs,
group
reported
markedly
reduced
right
fusiform
gyrus
(FFG)
inferior
occipital
gyrus,
whereas
elevated
left
middle
frontal
parietal
angular
gyrus.
The
exhibited
surged
bilateral
cerebellum
IX,
precuneus,
opercular
part
of
Unlike
group,
declined
FFG
calcarine
(CAL).
Besides,
CAL
negatively
correlated
scores
group.
CONCLUSION
This
study
shows
that
abnormal
patterns
MDD,
especially
CAL,
can
distinguish
from
its
subtype,
indicating
a
potential
biomarker.
Язык: Английский