Medicine,
Год журнала:
2024,
Номер
103(36), С. e39433 - e39433
Опубликована: Сен. 6, 2024
The
causal
effects
of
mental
health
problems
on
the
risk
infectious
diseases
remain
vague.
Investigating
them
via
observational
study
is
challenging
as
it
presents
possible
confounding
factors.
Therefore,
objective
this
was
to
utilize
Mendelian
randomization
(MR)
techniques
evaluate
relationship
between
and
diseases.
Multivariable
MR
analyses
were
performed
using
genome-wide
association
data
for
sleep
disorders
(N
=
216,700),
depression
500,199),
anxiety
290,361),
nervous
feelings
450,700),
unspecified
disorder
218,792),
pneumonia
486,484),
skin
subcutaneous
tissue
infection
(SSTI;
N
intestinal
(IIDs;
urinary
tract
463,010),
central
system
(CNS)
infections
218,792)
among
individuals
European
ancestry.
Independent
genetic
variants
significantly
(P
<
10-8)
associated
with
each
exposure
considered
instruments.
primary
analysis
used
an
inverse
variance-weighted
method,
followed
by
a
series
sensitivity
analyses.
Genetically
predicted
increased
SSTI
(odds
ratio
[OR],
1.29
[95%
confidence
interval
(CI),
1.05-1.59];
P
.017).
linked
CNS
(OR,
1.59
CI,
1.00-2.53];
.049)
(1.24
1.03-1.49];
.024).
IIDs
1.19
1.03-1.37];
.017)
1.21
1.02-1.43];
.029).
There
no
significant
evidence
prediction
in
IIDs,
infections,
SSTI,
pneumonia,
or
infection.
Sensitivity
showed
that
above
estimates
robust.
In
study,
we
demonstrated
disorders,
depression,
anxiety,
However,
found
support
causality
feelings,
Frontiers in Public Health,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 15, 2025
With
the
global
trend
of
aging,
stress
urinary
incontinence
is
becoming
more
common
in
older
adults,
which
may
have
some
impact
on
patients'
quality
life.
Social
alienation
can
generate
negative
emotions
such
as
anxiety,
depression,
loneliness,
and
morbid
stigma,
reduce
However,
current
status
social
different
among
adult
female
patients
with
incontinence.
Therefore,
this
study
categorizes
through
potential
analysis
to
understand
category
characteristics
level
patients,
explores
influencing
factors
categories
provide
a
reference
personalized
intervention
programs
for
future.
A
convenience
sampling
method
was
used
select
365
cases
from
March
2023
April
2024
three
communities
Jinzhou
City.
The
General
Information
Questionnaire,
Family
Care
Index
Scale,
Toronto
Alexithymia
Alienation
Scale
were
conduct
survey.
total
respondents
included,
finally
identified,
namely,
low
(29.0%),
medium
alienation-self
(49.4%),
high
(21.6%).
results
multifactorial
logistic
regression
showed
that
occupational
status,
marital
whether
living
alone,
place
residence,
BMI,
other
chronic
diseases,
narrative
disorders,
family
care
(P
<
0.05).
characterized
by
significant
number
categories,
healthcare
professionals
identify
each
at
an
early
stage,
basis
development
targeted
clinical
interventions
help
alienation.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 29, 2025
Overactive
bladder
(OAB)
is
a
prevalent
condition
among
older
adults
and
may
be
linked
to
cognitive
health.
This
study
explored
relationship
between
OAB
health
aged
60
≥
years
in
the
United
States,
using
NHANES
2011-2014.
A
cross-sectional
analysis
was
conducted
nationally
representative
sample
of
2,324
(45.95%
male,
54.05%
female),
within
755
individuals
have
OAB.
Cognitive
assessed
Consortium
Establish
Registry
for
Alzheimer's
Disease-Word
Learning
(CERAD
W-L),
Animal
Fluency
Test
(AFT),
Digit
Symbol
Substitution
(DSST).
defined
by
score
more
than
3
on
Bladder
Syndrome
Symptom
Score
(OABSS).
Depression
incidence
also
recorded.
Weighted
linear
regression
models
adjusted
demographic,
behavioral
factors,
comorbidities
(e.g.,
diabetes,
kidney
disease
etc.),
were
employed
examine
independent
association
The
results
indicated
that
scores
significantly
lower
group
compared
non-OAB
across
all
tests
(p<0.001).
depression
higher
(15%)
(6.05%)
Regression
revealed
14%
decrease
z-scores
patients
with
(β=-0.14,
CI
(95%)
[-0.22,
-0.06]).
Furthermore,
found
mediate
34.56%
[CI
(95%):
0.20,
0.69].
negative
robust
subgroups
demographics,
comorbidities.
study's
findings,
supported
mediation
analysis,
smoothed
curve
sensitivity
suggest
associated
OAB,
plays
an
important
mediating
role
this
association.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
Background
Urinary
incontinence
(UI)
is
a
common
and
troublesome
global
problem.
The
purpose
was
to
explore
the
relationship
between
muscle
quality
index
(MQI)
UI.
Methods
We
performed
secondary
analysis
of
National
Health
Nutrition
Examination
Survey
(NHANES)
database
(2011
2014).
Weighted
logistic
regression
used
analyze
MQI
Subgroup
analyses
were
further
conducted
investigate
relationship.
P
for
trend
interaction
also
conducted.
Results
A
total
2,779
participants
enrolled
in
study,
comprising
1,241
females
1,538
males
with
median
age
36
years.
prevalence
UI
approximately
25.45%.
In
adjusted
model,
weighted
multivariate
showed
that
significantly
negatively
associated
(OR,0.65;
95%CI,0.50
0.85).
Furthermore,
results
revealed
highest
group
had
33%
reduction
compared
lowest
less
than
0.05.
subgroup
analysis,
(OR,
0.64;
95%CI,
0.45
0.92),
under
40
years
old
0.85),
poverty-to-income
ratio
1
3
0.48;
0.29
0.78),
Non-Hispanic
Black
0.50;
0.87),
some
populations
without
hypertension
or
diabetes.
Conclusion
study
higher
lower
urinary
incontinence.
This
provides
insights
into
potential
preventive
strategies
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
Background
Clinical
observations
indicate
a
correlation
between
the
gut
microbiota
and
overactive
bladder
(OAB)
symptoms.
Nevertheless,
causal
relationship
mechanisms
OAB
symptoms
remain
elusive.
Methods
Two-sample
Mendelian
randomization
(MR)
analyses
were
performed
to
assess
association
symptoms,
including
urinary
incontinence
(UI).
Data
obtained
from
MiBioGen
International
Consortium
genome-wide
studies
(GWAS)
dataset
IEU
GWAS
database.
The
inverse
variance
weighted
method
was
used
as
primary
approach
in
MR
analysis,
with
median,
MR-Egger,
mode
methods
supplementary
approaches.
Sensitivity
employed
potential
violations
of
assumptions.
Results
Our
analysis
identified
seven
bacterial
taxa
nine
associated
UI.
Genera
Eubacteriumfissicatenumgroup
,
LachnospiraceaeNK4A136group
Romboutsia
protective
factors
against
OAB,
while
genera
Barnesiella
FamilyXIIIAD3011group
Odoribacter,
RuminococcaceaeUCG005
an
increased
risk
OAB.
A
higher
abundance
genus
Coprococcus3
order
Burkholderiales,
phylum
Verrucomicrobia
predicted
lower
Conversely,
class
Mollicutes,
Ruminococcus
gauvreauii
group,
Mollicutes
RF9,
Firmicutes
Tenericutes
positively
correlated
UI
risk.
sensitivity
excluded
influence
heterogeneity
horizontal
pleiotropy.
Conclusion
This
study
revealed
providing
new
insights
theoretical
foundation
identify
biomarkers
therapeutic
targets
for
patients
International Journal of Women s Health,
Год журнала:
2024,
Номер
Volume 16, С. 1607 - 1624
Опубликована: Сен. 1, 2024
This
study
examined
the
relationship
between
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
urinary
incontinence
in
adult
women
evaluated
potential
contribution
of
fatty
index
(FLI)
this
context.
International Neurourology Journal,
Год журнала:
2024,
Номер
28(Suppl 2), С. S97 - 105
Опубликована: Ноя. 29, 2024
Purpose:
This
study
aimed
to
provide
foundational
data
enhance
integrated
interventions
by
gaining
an
in-depth
understanding
of
the
perceptions
patients
experiencing
both
mental
illness
and
lower
urinary
tract
symptoms
(LUTS),
which
carry
a
high
risk
comorbidity
potential
mutual
exacerbation.Methods:
Data
were
collected
from
large
online
health
community
in
South
Korea,
active
among
individuals
with
their
families
(as
October
21,
2024:
113,060
members
368,352
posts).
Posts
containing
keywords
‘pee’
or
‘urine’
(a
total
986
posts)
analyzed
including
titles,
content,
categories.
Analyses
included
word
cloud,
latent
Dirichlet
allocation
topic
modeling,
category
frequency
analysis,
qualitative
analysis.Results:
The
findings
indicate
that
illness,
LUTS
are
perceived
as
side
effects
psychiatric
medications
regarded
inevitable.
Many
attempted
self-regulation
discontinuation
medication
instead
seeking
urological
treatment,
but
these
attempts
often
led
failure.
revealed
participants
used
explore
relationship
between
illness.
had
negative
impacts
on
family
social
life,
incontinence
exacerbated
emotional
distress
such
self-blame
despair.Conclusions:
Patients
engage
medication.
It
underscores
need
for
accurate
information
warnings
about
risks.
As
endure
discomfort
frustration
daily
symptom
deterioration
is
likely
necessitates
proactive
intervention
improve
quality
life.
enhances
impact
co-occurring
highlights
proper
guidance.
However,
it
has
limitations
reliance
self-reported
limited
sample
representativeness.
Future
research
can
address
issues
linking
medical
diagnoses
objective
expanding
size.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Abstract
Current
research
indicates
a
strong
association
between
inflammation
and
the
development
of
overactive
bladder
(OAB).
This
study
aims
to
explore
correlation
five
inflammatory
indices—Neutrophil/Lymphocyte
Ratio
(NLR),
Platelet/Lymphocyte
(PLR),
Lymphocyte/Monocyte
(LMR),
Albumin
×
Lymphocyte/(CRP
10)
(CALLY),
Systemic
Immune-Inflammation
Index
(SII)—and
OAB.
We
analyzed
data
from
12,689
participants
2005
2010,
defining
OAB
by
nocturia
urgent
urinary
incontinence.
Logistic
regression
models,
Receiver
Operating
Characteristic
(ROC)
curves,
restricted
cubic
splines
(RCS),
subgroup
analyses
were
utilized
assess
relationship
indices
Results
indicate
that
all
selected
reflect
levels
in
patients,
with
NLR
showing
outstanding
predictive
performance
significant
positive
risk.
Higher
values
are
associated
increased
likelihood
(OR=1.356,
95%
CI=1.241-1.483,
P<0.001),
incidence
rises
increasing
quartiles.
reveals
OAB,
suggesting
could
serve
as
safe,
effective,
independent
indicator
compared
other
markers.
finding
underscores
potential
role
clinical
tool
for
identifying
individuals
at
risk
Reproductive health of woman,
Год журнала:
2024,
Номер
2, С. 45 - 52
Опубликована: Март 29, 2024
Urinary
tract
infections
(UTIs)
are
a
significant
public
health
problem.
Every
year
the
situation
becomes
more
complicated
due
to
high
rate
of
recurrence
and
growth
resistance
among
population.Research
results
show
that
about
150
million
people
suffer
from
bacterial
urinary
every
year,
6
visits
doctor
UTIs
registered
in
US
which
than
2
related
cystitis.
In
Ukraine,
rank
first
all
urological
diseases,
170,000
cystitis
patients
annually
for
time.
20%
girls
till
20
years
old
have
at
least
one
episode
acute
cystitis,
25–40%
women
experience
recurrent
within
after
an
cystitis.Treatment
depends
on
influence
many
factors,
include:
age,
gender,
state
immune
system,
recurrences,
pathologies,
severity
disease
risk
developing
multiple
drug
resistance.
For
prevention
antibiotic
development,
it
is
recommended
use
combined
herbal
preparations
long-term
episodes
cystitis.The
objective:
evaluate
effectiveness
proposed
preparation
complex
treatment
with
uncomplicated
chronometry
onset
action
monotherapy.Materials
methods.
The
study
was
included
main
group
involved
40
persons
who
were
prescribed
antibacterial
therapy
form
single
fosfomycin
trometamol
3
g
per
os
or
sulfamethoxazole/trimethoprim
400
mg/80
mg
tablets
twice
day
5
days
combination
(a
medicinal
plant
components
centaury
herb,
lovage
root
rosemary
leaves)
1
tablet
times
months.
Patients
comparison
(40
subjects)
received
only
therapy.Treatment
side
effects
evaluated
10
its
initiation.
Determination
presence
frequency
carried
out
months
onset.
At
second
stage
study,
as
relief
signs.At
appearance
signs
end
primary
course,
both
groups
immediately
start
using
preparation,
three
day.
To
determine
speed
pharmaceutical
drug,
each
patient
asked
fill
questionnaire
regarding
reduction
disappearance
symptoms.Results.
After
completion
treatment,
positive
effect
observed
38
(95.0%)
37
(92.5%)
group,
leukocyturia
stopped
39
(97.5%)
patients,
respectively,
dysuria
–
(95.0%),
respectively.
maximally
manifested
reducing
has
important
clinical
significance.It
quite
clear
occurrence
sporadic
timely
effective
self-sufficient
accordingly
hides
phytotherapy.
Use
provides
rehabilitation
lower
aquaretic
antimicrobial
prevents
disease.Conclusions.
part
demonstrated
95.0%
patients.
appointment
origin
97.5%
allows
us
recommend
order
prevent
relapses
disease.The
helps
reduce
feeling
incomplete
emptying
bladder,
starting
62.9±17.0
min
pollakiuria
by
179.7±23.0
min,
make
quick
assess
phytotherapy
and,
if
necessary
strengthen