The gut–airway microbiome axis in health and respiratory diseases
Nature Reviews Microbiology,
Год журнала:
2024,
Номер
22(8), С. 492 - 506
Опубликована: Май 22, 2024
Язык: Английский
Cytokine Levels in Mother-infant Pairs at Term and Preterm Delivery
The Pediatric Infectious Disease Journal,
Год журнала:
2025,
Номер
44(2S), С. S61 - S65
Опубликована: Фев. 1, 2025
Background:
Cell-mediated
immunity
(CMI),
in
addition
to
the
humoral
immune
response,
is
crucial
clearing
infections.
Cytokines
are
important
mediators
of
system
and
play
a
role
during
pregnancy
childbirth.
This
study
assesses
circulating
cytokine
levels
peripartum
maternal
cord
blood
samples
at
term
preterm
delivery.
Materials
methods:
Samples
from
37
mother-infant
pairs
previously
conducted
immunization
were
used
quantify
6
cytokines
[interferon
(IFN)-γ,
interleukin
(IL)-10,
IL-17A,
IL-1β,
IL-6
tumor
necrosis
factor-α]
using
Meso
Scale
Discovery®
ultrasensitive
S-plex
assay.
The
effect
various
factors
on
measured
was
determined.
Results:
Weak
moderate
correlations
between
found.
A
trend
for
lower
compared
with
delivery
observed.
also
seen
cesarean
section
vaginal
multiparous
primiparous
women,
but
only
serum
samples.
After
correction
other
variables,
effects
gestational
age
parity
significant
for,
respectively,
IFN-γ
serum.
Conclusions:
assessment
deliveries
provides
unique
insight
into
presence
their
interplay
It
highlights
complexity
maternal-fetal
relationship
underscores
need
further
investigation
origin
newborns
impact
vaccination
CMI
Язык: Английский
Prenatal Maternal COVID-19 and Offspring Risk for Morbidities Up to the Age of One Year
The Pediatric Infectious Disease Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Background:
Prenatal
maternal
coronavirus
disease
2019
(COVID-19)
infection
may
worsen
the
clinical
course
of
and
increase
risk
for
adverse
obstetric
neonatal
outcomes
depending
on
severity
timing
exposure.
Data
regarding
long-term
impact
offspring
exposed
to
prenatal
COVID-19
are
still
limited.
Objective:
To
study
association
between
infectious
diseases,
respiratory
complications,
developmental
delay
up
age
1
year.
Study
design:
A
retrospective
cohort
was
conducted.
The
included
19,050
women-offspring
dyads
who
delivered
at
Soroka
University
Medical
Center
December
30,
2020,
July
2022,
them,
2663
(14%)
women
were
diagnosed
with
during
pregnancy.
Pregnancy,
delivery
complications
compared
pregnancy
not.
Multivariable
logistic
regression
models
performed
examine
selected
diagnoses,
while
adjusting
background
characteristics,
among
offspring,
compare
incidence
diagnoses
based
trimester
infection.
Results:
Offspring
mothers
infections
higher
viral
[adjusted
odds
ratio
(OR)
=
1.167;
95%
CI
1.028–1.325,
P
0.017],
specifically
third
trimester.
lower
in
cases
where
second
These
increased
COVID-19;
however,
only
if
infected
earlier
No
associations
observed
(0.8%
vs.
1.1%,
OR
0.724,
0.46–1.14,
0.161)
or
(3.3%
4%,
0.83,
0.662–1.041,
0.107).
Conclusions:
year
old,
late
gestation
including
first
life.
Язык: Английский
Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review
Medicina,
Год журнала:
2024,
Номер
60(9), С. 1457 - 1457
Опубликована: Сен. 5, 2024
Feto-maternal
microchimerism
is
the
bidirectional
transfer
of
cells
through
placenta
during
pregnancy
that
can
affect
health
both
mother
and
offspring,
even
in
childhood
or
adulthood.
However,
seems
to
have
different
consequences
mother,
who
already
has
a
developed
immune
system,
than
fetus,
which
vulnerable
with
immature
defense
mechanisms.
Studies
shown
presence
fetal
microchimeric
be
associated
reduced
growth,
pre-eclampsia,
miscarriage,
premature
birth,
risk
autoimmune
disease
development
future.
some
studies
report
they
may
also
play
positive
role
healing
maternal
tissue,
cancer
cardiovascular
disease.
There
are
few
literature
regarding
autoimmunity.
Even
fewer
examined
their
association
potential
triggering
diseases
later
offspring's
life.
The
objectives
this
review
were
elucidate
mechanisms
underlying
between
conditions
offspring.
Based
on
our
findings,
several
hypotheses
been
proposed
possible
by
trigger
In
Type
1
diabetes,
implicated
either
attacking
pancreatic
β-cells,
producing
insulin,
differentiating
into
endocrine
exocrine
cells,
serving
as
markers
tissue
damage.
Additionally,
suggested
for
onset
neonatal
lupus
erythematosus.
context,
induce
graft-versus-host
host-versus-graft
reaction
function
effectors
within
tissues,
contribute
healing.
These
found
participate
inflammation
fibrosis
processes,
well
differentiate
myocardial
potentially
an
response.
Moreover,
involvement
supported
such
juvenile
idiopathic
inflammatory
myopathies,
Sjögren's
syndrome,
systemic
sclerosis,
biliary
atresia,
rheumatoid
arthritis.
Conversely,
no
celiac
findings
suggest
autoimmunity
remains
controversial
topic
warrants
further
investigation.
Язык: Английский
Fusobacterium necrophorum and Fusobacterium varium are commensal members of the bovine reproductive microbiota and may colonize calf prenatally
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
ABSTRACT
Fusobacterium
necrophorum
is
an
important
pathogen
associated
with
several
infectious
diseases
in
cattle.
However,
recent
sequencing-based
studies
have
indicated
that
F.
positively
pregnancy
beef
cows
and
the
most
abundant
genus
bull
seminal
microbiota,
suggesting
potential
role
of
reproductive
health
fertility.
Here,
we
performed
a
comprehensive
screening
to
1)
determine
whether
(subspecies
[FNN]
funduliforme
[FNF]),
varium
(FV)
are
part
commensal
members
microbiota
cattle;
2)
explore
these
spp.
colonized
calf
prenatally.
For
this,
screened
11
different
sample
types
including
bovine
ram
semen,
vaginal
uterine
swabs,
fecal
samples,
as
well
samples
from
180-
260-days
old
fetuses
their
respective
dams
using
both
quantitative
PCR
(514
samples)
targeted
culturing
(499
samples).
By
qPCR,
all
were
detected
across
types,
FNF
being
highly
prevalent
semen
(66.7%)
maternal
ruminal
fluids
(87.1%),
which
was
confirmed
by
culturing.
All
identified
(3.1%-9.4%)
placental
caruncles,
fetal
fluids,
meconium
(2.7%
-
26.3%)
qPCR
not
isolated
culture
method.
Overall,
our
results
suggest
member
healthy
male
FNF,
FNN
FV
present
vagino-uterine
intestine
Язык: Английский
Placental and fetal microbiota in rhesus macaque: a case study using metagenomic sequencing
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
Abstract
Recent
evidence
challenging
the
notion
of
a
sterile
intrauterine
environment
has
sparked
research
into
origins
and
effects
fetal
microbiota
on
immunity
development
during
gestation.
Rhesus
macaques
(RMs)
serve
as
valuable
non-human
primate
(NHP)
models
due
to
their
similarities
humans
in
development,
placental
structure,
immune
response.
In
this
study,
metagenomic
analysis
was
applied
placenta,
umbilical
cord,
spleen,
gastrointestinal
(GI)
tissues
an
unborn
RM
fetus,
maternal
intestine,
revealing
diversity
functionality
microbes
these
tissues.
We
observed
substantial
microbial
sharing
between
mother
with
composition
placenta
cord
more
closely
resembling
that
organs
than
intestine.
Notably,
compared
other
adult
RMs,
there
clear
convergence
microbiota,
alongside
distinct
differences
adults
which
underscores
unique
profiles
environments.
Furthermore,
displayed
less
developed
carbohydrate
metabolism
capacity
RMs.
It
also
shared
antibiotic
resistance
genes
(ARGs)
both
microbiomes,
indicating
potential
vertical
transmission.
Comparative
metagenomes
fetus
human
revealed
significant
genes,
yet
showed
certain
abundant
microbiota.
Collectively,
our
results
contribute
comprehensive
understanding
macaques.
Язык: Английский
The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits
Seminars in Immunopathology,
Год журнала:
2024,
Номер
46(5)
Опубликована: Авг. 26, 2024
Skin
scar
formation
following
Bacille
Calmette-Guérin
(BCG)
or
smallpox
(Vaccinia)
vaccination
is
an
established
marker
of
successful
and
'vaccine
take'.
Potent
pathogen-specific
(tuberculosis;
smallpox)
pathogen-agnostic
(protection
from
diseases
unrelated
to
the
intentionally
targeted
pathogen)
effects
BCG
vaccines
hold
significant
translational
potential.
Yet
despite
their
use
for
centuries,
how
occurs
local
skin-based
events
relate
systemic
that
allow
these
two
deliver
powerful
health
promoting
has
not
yet
been
determined.
We
review
here
what
known
about
occurring
in
skin
place
this
knowledge
context
overall
impact
on
human
with
a
particular
focus
maternal-child
health.
Язык: Английский