Antioxidants,
Год журнала:
2022,
Номер
11(6), С. 1053 - 1053
Опубликована: Май 26, 2022
The
SARS-CoV-2
coronavirus
pandemic
outbreak
in
2019
resulted
the
need
to
search
for
an
effective
and
safe
strategy
treating
infected
patients,
relieving
symptoms,
preventing
severe
disease.
is
RNA
virus
that
can
cause
acute
respiratory
failure
thrombosis,
as
well
impair
circulatory
system
function.
Permanent
damage
heart
muscle
or
other
cardiovascular
disorders
may
occur
during
after
infection.
course
of
disease
associated
with
release
large
amounts
pro-inflammatory
cytokines.
Due
their
documented
anti-inflammatory,
antioxidant,
antiviral
effects,
reactive
sulfur
compounds,
including
hydrogen
sulfide
(H2S),
lipoic
acid
(LA),
N-acetylcysteine
(NAC),
glutathione
(GSH),
some
lesser-known
have
attracted
interest
scientists
treatment
prevention
adverse
effects
diseases
caused
by
SARS-CoV-2.
This
article
reviews
current
knowledge
about
various
endogenous
exogenous
compounds
discusses
possibility,
cases
results,
use
prophylaxis
COVID-19.
Nutrients,
Год журнала:
2022,
Номер
14(11), С. 2194 - 2194
Опубликована: Май 25, 2022
Coronavirus
illness
(COVID-19)
is
an
infectious
pathology
generated
by
intense
severe
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
This
disease
has
emerged
in
2019.
The
COVID-19-associated
pandemic
considerably
affected
the
way
of
life
and
economy
world.
It
consequently
crucial
to
find
solutions
allowing
remedying
or
alleviating
effects
this
disease.
Natural
products
have
been
perpetual
application
from
immemorial
time
given
that
they
are
attested
be
efficient
towards
several
illnesses
without
major
side
effects.
Various
studies
shown
plant
extracts
purified
molecules
a
promising
inhibiting
impact
coronavirus.
In
addition,
it
substantial
understand
characteristics,
susceptibility
diet
on
patients
infected
with
COVID-19.
review,
we
recapitulate
influence
pure
medicinal
plants
We
approach
possibilities
treatment/co-treatment
feeding
applied
also
show
complications
associated
nutrient
deficiencies
then
discuss
food
groups
COVID-19
pathogenesis.
Then,
covered
emerging
technologies
using
plant-based
SARS-CoV-2
vaccine.
conclude
giving
curative
therapy
recommendations
which
potential
interest
infection
could
pave
for
pharmacological
treatments
co-treatments
Alzheimer’s
Disease
(AD),
a
progressive
and
debilitating
condition,
is
reported
to
be
the
most
common
type
of
dementia,
with
at
least
55
million
people
believed
currently
affected.
Many
causation
hypotheses
AD
exist,
yet
intriguing
link
between
viral
infection
its
possible
contribution
known
etiology
has
become
an
attractive
focal
point
research
for
field
challenging
study
task.
In
this
review,
we
will
explore
historical
perspective
milestones
that
led
investigate
connection
AD.
Specifically,
several
viruses
such
as
Herpes
Simplex
Virus
1
(HSV-1),
Zika
virus
(ZIKV),
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
along
others
mentioned,
include
various
presently
considered
within
field.
We
delve
into
strong
evidence
implicating
these
in
development
also
extend
beyond
mere
associations
by
carefully
analyzing
potential
mechanisms
which
may
contribute
pathology.
This
includes
but
not
limited
direct
neuronal
infections,
dysregulation
immune
responses,
impact
on
protein
processing.
Controversies
challenges
viral-AD
relationship
emerge
tease
out
considered.
Looking
forward,
emphasize
future
directions
should
take
tackle
remaining
unanswered
questions
glaring
gaps
persist.
Overall,
review
aims
provide
comprehensive
survey
past,
present,
infections
their
association
development.
This
review
explores
the
therapeutic
potential
of
intranasal
chlorpheniramine
maleate
(iCPM)
in
managing
both
acute
COVID-19
and
Long
COVID
by
integrating
histamine
H1
receptor
antagonism
bitter
taste
(T2R)
activation.
Current
literature
on
histamine-mediated
inflammation,
T2R
activation,
dual-action
mechanisms
iCPM
were
analyzed.
Emphasis
was
placed
its
antiviral,
anti-inflammatory,
mucosal
immunity-enhancing
properties.
demonstrates
significant
efficacy
addressing
symptoms
inhibiting
inflammatory
pathways
reducing
cytokine
storms.
As
a
agonist,
it
enhances
immunity
through
nitric
oxide
production,
mucociliary
clearance,
antimicrobial
peptide
synthesis,
viral
replication
supporting
respiratory
health.
Additionally,
shows
promise
mitigating
persistent
long
COVID,
including
fatigue,
brain
fog,
dysfunction,
chronic
inflammation
residual
activity.
The
integration
activation
positions
as
novel
dual-target
therapy
for
infections.
Its
localized
delivery
broad
mechanism
action
make
promising
candidate
phases
COVID-19.
Future
research
should
focus
large-scale
clinical
trials
personalized
approaches
based
genetic
variations
pathways.
Frontiers in Physiology,
Год журнала:
2021,
Номер
12
Опубликована: Окт. 8, 2021
In
this
article
we
discuss
the
concept
of
accessible
plasma
membrane
cholesterol
and
its
involvement
as
a
signalling
molecule.
Changes
in
cholesterol,
although
only
being
minor
context
total
cell
are
key
regulator
overall
cellular
homeostasis
by
SREBP
pathway.
Accessible
also
provides
second
messenger
between
patched
1
smoothened
hedgehog
pathway
important
during
development,
depletion
may
provide
mechanism
resistance
to
microbial
pathogens
including
SARS-CoV-2.
We
revise
hypothesis
that
oxysterols
form
instance
rapidly
acting
paracrine
version
cholesterol.
Cells,
Год журнала:
2021,
Номер
10(8), С. 2078 - 2078
Опубликована: Авг. 13, 2021
Oxysterols,
or
cholesterol
oxidation
products,
are
naturally
occurring
lipids
which
regulate
the
physiology
of
cells,
including
those
immune
system.
In
contrast
to
effects
that
mediated
through
nuclear
receptors
by
epigenetic
mechanism,
take
tens
minutes
occur,
changes
in
activities
cell-surface
caused
oxysterols
can
be
extremely
rapid,
often
taking
place
within
subsecond
timescales.
Such
receptor
allow
for
regulation
fast
cellular
processes,
such
as
motility,
secretion
and
endocytosis.
These
processes
play
critical
roles
both
innate
adaptive
systems.
This
review
will
survey
two
broad
classes
(G-protein
coupled
(GPCRs)
ion
channels),
mechanisms
products
act
on
them,
their
presence
functions
different
cell
types
Overall,
this
highlight
potential
oxysterols,
synthetic
derivatives
physiological
therapeutic
modulation
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103310 - 103310
Опубликована: Авг. 19, 2024
Post-COVID-19
syndrome
(PCS)
remains
a
major
health
issue
worldwide,
while
its
pathophysiology
is
still
poorly
understood.
Systemic
oxidative
stress
(OS)
may
be
involved
in
PCS,
which
reflected
by
lower
circulating
free
thiols
(R-SH,
sulfhydryl
groups),
as
they
are
receptive
to
rapid
oxidation
reactive
species.
This
study
aimed
investigate
the
longitudinal
dynamics
of
serum
R-SH
after
SARS-CoV-2
infection
and
association
with
development
PCS
individuals
mild
COVID-19.
European Journal of Immunology,
Год журнала:
2023,
Номер
53(9)
Опубликована: Июнь 27, 2023
Abstract
Cholesterol
plays
essential
roles
in
biological
processes,
including
cell
membrane
stability
and
myelin
formation.
can
be
metabolized
to
oxysterols
by
enzymatic
or
nonenzymatic
ways.
Nonenzymatic
cholesterol
metabolites,
also
called
cholesterol‐autoxidation
are
formed
dependent
on
the
oxidation
of
reactive
oxygen
species
(ROS)
such
as
OH•
nitrogen
species,
ONOO
−
.
Cholesterol‐autoxidation
metabolites
abundantly
produced
diseases
inflammatory
bowel
disease
atherosclerosis,
which
associated
with
oxidative
stress.
Recent
studies
have
shown
that
further
regulate
immune
system.
Here,
we
review
literature
summarize
how
25‐hydroxycholesterol
(25‐OHC),
7α/β‐OHC,
7‐ketocholesterol,
deal
occurrence
development
infectious
through
pattern
recognition
receptors,
inflammasomes,
ROS
production,
nuclear
G‐protein‐coupled
receptor
183,
lipid
availability.
In
addition,
include
research
regarding
these
COVID‐19
infection
discuss
our
viewpoints
future
directions.
