[BPy][OH] Immobilized Hydrotalcite Clay Catalytic System for 1,2-dihyd-roquinazolines Synthesis DOI
Vivek Srivastava

Current Organocatalysis, Год журнала: 2023, Номер 11(1), С. 33 - 43

Опубликована: Июль 27, 2023

Abstract: We easily synthesized two ionic liquids, [BMIM][OH] and [BPy][OH], with high yield. found that hydrotalcite clay, mediated by these is a highly effective catalyst for synthesizing biologically active 1,2-dihydroquinazoline derivatives. Using simple reaction protocol easy product isolation steps, we successfully 18 different derivatives were able to recycle the catalysts up 8 times. Overall, use of [BPy][OH] provide more efficient environmentally friendly method quinazolines compared traditional methods often require harsh conditions toxic reagents. Background: 1,2-Dihydroquinazolines are an important class heterocyclic compounds diverse biological activities, including anticancer, antifungal, antibacterial properties. They also exhibit other pharmacological activities such as antihypertensive, anti-inflammatory, antiviral effects. The synthesis 1,2-dihydroquinazolines dates early 20th century when they first Pictet Huber in 1911 condensation anthranilic acid aldehydes or ketones presence strong acids. Since then, numerous have been developed their synthesis, cyclization o-aminobenzamides, o-aminoaryl ketones, Lewis acids transition metals. In recent years, development new synthetic selective has great interest chemists, particularly pharmaceutical industry. These include microwave irradiation, ultrasound, liquids green solvents. : area research, continue be improve properties various applications. Methods: yields. Results: our results insights into sustainable 1, 2-dihydroquinazolines. Conclusion: summary, studies demonstrated liquid clay catalytic system could used 2-dihydroquinazolines using aromatic carbonyl compounds, amino benzophenone derivatives, aldehydes. electron-donating substituents phenyl group provided higher yields than electron-withdrawing groups, para position aldehyde had significant effect ortho meta position. Our was recyclable eight runs without loss activity.

Язык: Английский

Assessment of quinazoline derivatives as efficient corrosion inhibitor for carbon steel in acidic environment. A theoretical and practical analysis DOI Creative Commons
M. Abdallah,

Arej S. Al-Gorair,

H. Hawsawi

и другие.

International Journal of Electrochemical Science, Год журнала: 2025, Номер unknown, С. 100990 - 100990

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

2
One-pot synthesis of quinazolinone heterocyclic compounds using functionalized SBA-15 with natural material ellagic acid as a novel nanocatalyst DOI Creative Commons

Nazanin Mohassel Yazdi,

Mohammad Reza Naimi‐Jamal

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 16, 2024

The nanoporous compound SBA-15 was functionalized using (3-aminopropyl)trimethoxysilane (APTES). Then the obtained product modified with ellagic acid (ELA), a bioactive polyphenolic compound. structure of prepared composition SBA-15@ELA extensively characterized and confirmed by various techniques, such as Fourier-transform infrared (FT-IR) spectroscopy, Energy dispersive X-ray (EDX) elemental analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), diffraction (XRD), transmission (TEM) N2 adsorption-desorption isotherms (BET). novel, recoverable, heterogenous used to investigate its catalytic effect in synthesis 4-oxo-quinazoline derivatives (19 examples) high yields (78-96%), an important class nitrogen-containing heterocyclic compounds. use inexpensive mesoporous catalyst surface area, along easy recovery simple filtration are among advantages this catalysis research work. has been at least 6 consecutive runs without significant loss activity.

Язык: Английский

Процитировано

5
tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations DOI Open Access
Ravi Varala,

Vittal Seema,

Mohamed Hussein

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(30)

Опубликована: Авг. 6, 2024

Abstract tert‐ Butyl hydroperoxide (tBuOOH, TBHP) is a commonly used in many oxidation processes. The primary factors contributing to the increasing usefulness of TBHP include its affordability, eco‐friendliness, exceptional efficacy, and capacity substitute harmful or rare heavy metal oxidants. In this sexennial update, we thoroughly critically examined most noteworthy applications C−H functionalization heteroatom‐heteroatom bond formation reactions from 2018 till present. review has been subdivided based on nature bonds being formed. focuses advantages disadvantages using synthetic organic transformations, as well breadth their use underlying mechanisms involved.

Язык: Английский

Процитировано

4
Ruthenium(II)-Catalyzed Synthesis of N-Heterocycles via Ac-ceptorless Dehydrogenative Condensation DOI
Chong Zhang, Bowen Hu, Dafa Chen

и другие.

Journal of Organometallic Chemistry, Год журнала: 2025, Номер 1029, С. 123545 - 123545

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
An efficient and green synthesis of 2-phenylquinazolin-4(3H)-ones via t-BuONa-mediated oxidative condensation of 2-aminobenzamides and benzyl alcohols under solvent- and transition metal-free conditions DOI Creative Commons
Vy T. Nguyen,

Dat P. Tran,

Tung T. Nguyen

и другие.

Green Processing and Synthesis, Год журнала: 2023, Номер 12(1)

Опубликована: Янв. 1, 2023

Abstract Quinazolinone synthesis usually requires employing sensitive substrates, hazardous solvents, large excess oxidants, and expensive catalysts. In this study, an efficient environmentally benign pathway was developed to synthesize 2-phenylquinazolin-4(3 H )-one via oxidative coupling between commercially available stable chemicals, including 2-aminobenzamide benzyl alcohol without toxic oxidizing agents transition-metal A high yield of the desired product (up 84%) obtained at 120°C for 24 h in presence oxygen as a green oxidant t -BuONa base. Importantly, study scope expanded toward successfully producing various derivatives moderate-to-good yields. Furthermore, control experiments proposed that conversion involved initial partial oxidation benzaldehyde intermediate under basic conditions, followed by condensation, intramolecular nucleophilic addition, dehydrogenation )-one.

Язык: Английский

Процитировано

3
Synthesis of 2-Amino-quinazolin-4(3H)-ones Using 2-Bromo-N-phenylbenzamide and Cyanamide Ullmann Cross-Coupling DOI
Zhongjie Wang, Yan Wang,

R. AN

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Herein, an approach for synthesizing 2-amino-3-substituted quinoline-4(3

Язык: Английский

Процитировано

0
Impact of Molecular and Crystal Structure on the Melting Points in Halo-Substituted Phenyl-Quinazolinones DOI Creative Commons
Ivica Đilović, Nenad Judaš, Mario Komar

и другие.

Crystals, Год журнала: 2024, Номер 15(1), С. 39 - 39

Опубликована: Дек. 30, 2024

Three halo-substituted phenyl-quinazolinone derivatives were prepared and structurally characterized [1 = 3-(4-chlorophenyl)-6-iodo-2-methylquinazolin-4(3H)-one, 2 6-iodo-3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one, 3 7-chloro-2-methyl-3-[4-(trifluoromethoxy)phenyl]quinazolin-4(3H)-one)] in order to explore the relationship between structure melting point this group of compounds. Depending on compound, molecules are interconnected by weak π∙∙∙π interactions, have I···Cl or Cl···Cl halogen bonding, primarily form C–H∙∙∙N, C–H∙∙∙O, interactions (no bonding). The presence OCF3 leads fluorine atoms that shorter than sum van der Waals radius for fluorine, suggesting these contribute overall lattice energy. sequence points cannot be fully explained intermolecular present solid state (enthalpy factor). To address this, a concept related entropy called functional rotation influence, which relates decrease fusion caused rotational freedom polyatomic groups, was introduced. Analysis previously synthesized 3-phenylquinazolinones showed compounds with highest quinazoline-substituted phenyl-nitro-substituted ones. Among halo-phenyl-substituted compounds, follows ortho < meta para. Regarding atom type, is Cl ≈ Br > F I enantiopure racemic Also, correlates bond energy (I F) only when geometry favorable.

Язык: Английский

Процитировано

0
[BPy][OH] Immobilized Hydrotalcite Clay Catalytic System for 1,2-dihyd-roquinazolines Synthesis DOI
Vivek Srivastava

Current Organocatalysis, Год журнала: 2023, Номер 11(1), С. 33 - 43

Опубликована: Июль 27, 2023

Abstract: We easily synthesized two ionic liquids, [BMIM][OH] and [BPy][OH], with high yield. found that hydrotalcite clay, mediated by these is a highly effective catalyst for synthesizing biologically active 1,2-dihydroquinazoline derivatives. Using simple reaction protocol easy product isolation steps, we successfully 18 different derivatives were able to recycle the catalysts up 8 times. Overall, use of [BPy][OH] provide more efficient environmentally friendly method quinazolines compared traditional methods often require harsh conditions toxic reagents. Background: 1,2-Dihydroquinazolines are an important class heterocyclic compounds diverse biological activities, including anticancer, antifungal, antibacterial properties. They also exhibit other pharmacological activities such as antihypertensive, anti-inflammatory, antiviral effects. The synthesis 1,2-dihydroquinazolines dates early 20th century when they first Pictet Huber in 1911 condensation anthranilic acid aldehydes or ketones presence strong acids. Since then, numerous have been developed their synthesis, cyclization o-aminobenzamides, o-aminoaryl ketones, Lewis acids transition metals. In recent years, development new synthetic selective has great interest chemists, particularly pharmaceutical industry. These include microwave irradiation, ultrasound, liquids green solvents. : area research, continue be improve properties various applications. Methods: yields. Results: our results insights into sustainable 1, 2-dihydroquinazolines. Conclusion: summary, studies demonstrated liquid clay catalytic system could used 2-dihydroquinazolines using aromatic carbonyl compounds, amino benzophenone derivatives, aldehydes. electron-donating substituents phenyl group provided higher yields than electron-withdrawing groups, para position aldehyde had significant effect ortho meta position. Our was recyclable eight runs without loss activity.

Язык: Английский

Процитировано

0