Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4(2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101304 - 101304
Опубликована: Янв. 1, 2024
A
diverse
set
of
tetrahydrobenzofuran-4(2H)-one
derivative
4(a-o)
were
synthesized
using
a
one-pot
treatment
dimedone,
3-(1H-imidazol-1-yl)benzaldehyde,
and
different
phenacyl
bromide
by
utilizing
cesium
carbonate
as
cost-effective
catalyst
in
acetonitrile
under
mild
reaction
condition.
During
the
synthesis
compounds,
two
carbon–carbon
(C–C)
bonds
one
carbon–oxygen
(C–O)
bond
are
formed.
All
compounds
obtained
with
moderate
to
good
yield.
The
underwent
screening
assess
their
antimicrobial
antimalarial
properties.
Compounds
4
l
(117
µM)
4d
(145
exhibited
highest
potency
against
A.
baumannii
Car.
Resistant
P.
aeruginosa
comparison
standard
drug
chloramphenicol
(155
µM),
respectively.
Compound
(234
displayed
efficacy
C.
albicans
than
that
drug,
fluconazole
(327
while
4f
(1018
showed
greater
niger
griseofulvin
(1417
µM).
In
addition,
all
titled
activity.
Among
them,
(1.60
has
falciparum
quinine
(2.71
Since
compound
exhibits
strong
antibacterial
fungal
action
among
synthetics,
it
shows
remarkable
binding
affinities
−8.5
kcal
mol−1
−9.1
Язык: Английский
Visible-Light-Induced Imine Hydrogenation Catalyzed by Thioxanthone-TfOH Complex
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Amino
compounds
are
important
molecules,
commonly
found
in
nature
and
widely
applied
industrial
production.
Recently,
photocatalysis
has
been
discovered
as
an
efficient
method
to
synthesize
amino
by
promoting
imine
hydrogenation.
In
this
work,
a
strategy
of
hydrogenation
catalyzed
2e–
consecutive
photoinduced
electron
transfer
(ConPET)
process
thioxanthone-TfOH
complex
(9-HTXTF)
was
thoroughly
investigated
with
its
reaction
conditions
optimized,
substrate
scope
examined,
mechanism
elucidated,
which
provides
for
synthesizing
compounds.
Язык: Английский
Ruthenium(II)-Catalyzed Synthesis of N-Heterocycles via Ac-ceptorless Dehydrogenative Condensation
Journal of Organometallic Chemistry,
Год журнала:
2025,
Номер
1029, С. 123545 - 123545
Опубликована: Янв. 31, 2025
Язык: Английский
A Comprehensive Investigation of Diverse Synthetic Methodologies for Constructing Quinoline Frameworks: A Critical Overview
ChemistrySelect,
Год журнала:
2025,
Номер
10(10)
Опубликована: Март 1, 2025
Abstract
Recently,
quinoline
has
emerged
as
a
critical
heterocyclic
structure,
attracting
attention
for
its
diverse
industrial
and
synthetic
organic
chemistry
applications.
This
compound
is
essential
developing
novel
lead
compounds
in
drug
discovery
extensively
studied
therapeutic
derivatives
medicinal
chemistry.
An
extensive
body
of
literature
details
the
methodologies
synthesizing
this
key
scaffold
functionalization
to
enhance
biological
efficacy.
Numerous
synthesis
protocols
have
been
documented,
highlighting
significance
ongoing
chemical
research.
These
include
various
strategies,
such
transition
metal‐catalyzed
reactions
environmentally
sustainable
processes,
which
are
crucial
constructing
functionalizing
derivatives.
review
aims
systematically
examine
procedures
findings,
addressing
limitations
these
pathways
their
environmental
impacts.
Additionally,
curated
selection
quinolines
will
be
presented.
Язык: Английский
TBAB-catalyzed 1,6-conjugate diazotization of para-quinone methides: A very effective access to polysubstituted α-diazocarbonyl compounds
Journal of Saudi Chemical Society,
Год журнала:
2024,
Номер
28(3), С. 101846 - 101846
Опубликована: Март 20, 2024
A
highly
efficient
diazotization
of
diazoacetates
with
para-quinone
methides
has
been
established
via
a
tetrabutyl
ammonium
bromide
(TBAB)-catalyzed
1,6-conjugated
addition
pathway.
This
methodology
affords
convenient,
safe,
and
rapid
way
to
generating
diverse
polysubstituted
α-diazocarbonyl
compounds,
displaying
good
functional
group
tolerance,
high
atom
economy,
easy
accessibility.
Язык: Английский