TBAB-catalyzed 1,6-conjugate diazotization of para-quinone methides: A very effective access to polysubstituted α-diazocarbonyl compounds DOI Creative Commons
Zhang-Qin Liu,

Sheng-Shu Liu,

Xiaoyu Guan

и другие.

Journal of Saudi Chemical Society, Год журнала: 2024, Номер 28(3), С. 101846 - 101846

Опубликована: Март 20, 2024

A highly efficient diazotization of diazoacetates with para-quinone methides has been established via a tetrabutyl ammonium bromide (TBAB)-catalyzed 1,6-conjugated addition pathway. This methodology affords convenient, safe, and rapid way to generating diverse polysubstituted α-diazocarbonyl compounds, displaying good functional group tolerance, high atom economy, easy accessibility.

Язык: Английский

Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4(2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study DOI Creative Commons
Savan S. Bhalodiya, Mehul P. Parmar, Dipti B. Upadhyay

и другие.

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101304 - 101304

Опубликована: Янв. 1, 2024

A diverse set of tetrahydrobenzofuran-4(2H)-one derivative 4(a-o) were synthesized using a one-pot treatment dimedone, 3-(1H-imidazol-1-yl)benzaldehyde, and different phenacyl bromide by utilizing cesium carbonate as cost-effective catalyst in acetonitrile under mild reaction condition. During the synthesis compounds, two carbon–carbon (C–C) bonds one carbon–oxygen (C–O) bond are formed. All compounds obtained with moderate to good yield. The underwent screening assess their antimicrobial antimalarial properties. Compounds 4 l (117 µM) 4d (145 exhibited highest potency against A. baumannii Car. Resistant P. aeruginosa comparison standard drug chloramphenicol (155 µM), respectively. Compound (234 displayed efficacy C. albicans than that drug, fluconazole (327 while 4f (1018 showed greater niger griseofulvin (1417 µM). In addition, all titled activity. Among them, (1.60 has falciparum quinine (2.71 Since compound exhibits strong antibacterial fungal action among synthetics, it shows remarkable binding affinities −8.5 kcal mol−1 −9.1

Язык: Английский

Процитировано

10

Visible-Light-Induced Imine Hydrogenation Catalyzed by Thioxanthone-TfOH Complex DOI

Shijie Sun,

Jiahong Wang, Hao Guo

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Amino compounds are important molecules, commonly found in nature and widely applied industrial production. Recently, photocatalysis has been discovered as an efficient method to synthesize amino by promoting imine hydrogenation. In this work, a strategy of hydrogenation catalyzed 2e– consecutive photoinduced electron transfer (ConPET) process thioxanthone-TfOH complex (9-HTXTF) was thoroughly investigated with its reaction conditions optimized, substrate scope examined, mechanism elucidated, which provides for synthesizing compounds.

Язык: Английский

Процитировано

0

Ruthenium(II)-Catalyzed Synthesis of N-Heterocycles via Ac-ceptorless Dehydrogenative Condensation DOI
Chong Zhang, Bowen Hu, Dafa Chen

и другие.

Journal of Organometallic Chemistry, Год журнала: 2025, Номер 1029, С. 123545 - 123545

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0

A Comprehensive Investigation of Diverse Synthetic Methodologies for Constructing Quinoline Frameworks: A Critical Overview DOI Open Access
Nagesh Dhanaji Chavan,

Balamurugan Shanmugavel,

Yasinalli Tamboli

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(10)

Опубликована: Март 1, 2025

Abstract Recently, quinoline has emerged as a critical heterocyclic structure, attracting attention for its diverse industrial and synthetic organic chemistry applications. This compound is essential developing novel lead compounds in drug discovery extensively studied therapeutic derivatives medicinal chemistry. An extensive body of literature details the methodologies synthesizing this key scaffold functionalization to enhance biological efficacy. Numerous synthesis protocols have been documented, highlighting significance ongoing chemical research. These include various strategies, such transition metal‐catalyzed reactions environmentally sustainable processes, which are crucial constructing functionalizing derivatives. review aims systematically examine procedures findings, addressing limitations these pathways their environmental impacts. Additionally, curated selection quinolines will be presented.

Язык: Английский

Процитировано

0

TBAB-catalyzed 1,6-conjugate diazotization of para-quinone methides: A very effective access to polysubstituted α-diazocarbonyl compounds DOI Creative Commons
Zhang-Qin Liu,

Sheng-Shu Liu,

Xiaoyu Guan

и другие.

Journal of Saudi Chemical Society, Год журнала: 2024, Номер 28(3), С. 101846 - 101846

Опубликована: Март 20, 2024

A highly efficient diazotization of diazoacetates with para-quinone methides has been established via a tetrabutyl ammonium bromide (TBAB)-catalyzed 1,6-conjugated addition pathway. This methodology affords convenient, safe, and rapid way to generating diverse polysubstituted α-diazocarbonyl compounds, displaying good functional group tolerance, high atom economy, easy accessibility.

Язык: Английский

Процитировано

0