Pseudo ternary phase diagram based PEGylated nano-dispersion of linezolid to promote wound regeneration: An in vitro and in vivo evaluation DOI
Bani Kumar Jana,

Ishita Singha,

Nusalu Puro

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Фев. 1, 2025

Open wounds are prone to bacterial infiltration mostly resistant strains like methicillin-resistant Staphylococcus aureus (MRSA), which affects healing of open wounds. Topical linezolid nano-dispersion using essential oils as nanoemulgel can increase solubility drug and bypass side-effects GI-irritation oral administration. Pseudo-ternary phase diagram was built optimise nanoemulsion. Surfactant/co-surfactant mixture (3:1), deionised water Oilmix (4:1) with were vortexed then ultrasonicated. 1% carbopol gel optimised nanoemulsion prepared characterised, exposed antimicrobial study, cytocompatibility study HEK293 cell-line, in vivo wound rat excision model. Histological performed confirm growth stratum corneum. Optimised formulation has particle size (244.6 ± 178.66 nm), polydispersity index (25%), entrapment efficiency (92.3 3.38%) vitro release (87.58 4.16%) best fitted Korsmeyer-Peppas kinetics Nanoemulgel F6 (0.2%w/w) found viscosity 5345 6 cP constituting a very excellent effect against MRSA. cells had shown good formulation. The contraction rate 99.66 0.57% at day 15 on daily application corneum almost fully regenerated. developed potential efficacy promote healing.

Язык: Английский

Wound healing potential of silver nanoparticles embedded in optimized bio-inspired hybridized chitosan soft and dry hydrogel DOI
Roxane Abdel-Gawad, Rihab Osman, Gehanne A.S. Awad

и другие.

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121526 - 121526

Опубликована: Окт. 24, 2023

Язык: Английский

Процитировано

22
Sodium hyaluronate hydrogel for wound healing and human health monitoring based on deep eutectic solvent DOI
Ting Huang, Yingbin Zhang,

Zhao Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 257, С. 128801 - 128801

Опубликована: Дек. 13, 2023

Язык: Английский

Процитировано

17
Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis DOI Creative Commons
Sayed E. El-Sayed, Neveen A. Abdelaziz, Ghadir S. El-Housseiny

и другие.

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Янв. 12, 2024

Abstract Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed promising antimycotic activity. This aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) control skin fungal ailments since nanosponges augment retention tested agents skin. Box-Behnken design used produce optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), particle size (PS) were assigned as dependent parameters, while independent process parameters polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, speed. The carbopol 940 then created by incorporating nanosponges. fit Higuchi’s kinetic release model best, according vitro drug release. Stability photodegradation studies revealed that NS-HG remained stable under conditions. formulation also higher antifungal activity against Candida albicans compared fluconazole. In vivo ODHP-NS-HG increased survival rates, wound contraction, healing gap inhibited inflammation other groups. histopathological examinations Masson’s trichrome staining improved records collagen deposition. Moreover, permeability through rats’ 1.5-folds isoconazole 1%. Therefore, based on these results, is potential carrier for enhanced topical delivery ODHP. Our pioneering research development produced naturally bacteria. Key points • successfully formulated statistically . new formula exhibited good stability, release, C. fluconazole Ex permeability, analysis high evidenced measurement various biochemical examination

Язык: Английский

Процитировано

8
Sertaconazole-Nitrate-Loaded Leciplex for Treating Keratomycosis: Optimization Using D-Optimal Design and In Vitro, Ex Vivo, and In Vivo Studies DOI Creative Commons
Menna M. Abdellatif, Mina Josef, Mohamed A. El-Nabarawi

и другие.

Pharmaceutics, Год журнала: 2022, Номер 14(10), С. 2215 - 2215

Опубликована: Окт. 18, 2022

This study aims to develop efficient topical therapy for keratomycosis using sertaconazolenitrate (STZN)-loaded leciplex (LP). The D-optimal design was used optimize STZN-loaded LP by utilizing soy phosphatidylcholine (SPC) molar ratio (X1), cationic surfactant (X2), and type (X3) as the independent variables, whereas their impact studied entrapment efficiency percent (EE; Y1), particle size (PS; Y2), polydispersity index (PDI; Y3), zeta potential (ZP; Y4), permeability coefficient (Kp; Y5). optimized formula evaluated regarding morphology, ex vivo permeation, mucoadhesion, stability, in studies. spherical showed EE of 84.87 ± 1.71%, PS 39.70 1.35 nm, PDI 0.242 0.006, ZP +54.60 0.24 mV, Kp 0.0577 0.0001 cm/h. permeation revealed that enhanced corneal deposition 2.78 12.49 folds, respectively, compared aqueous drug dispersion. Furthermore, stable promising mucoadhesion properties. Finally, studies superior dispersion treating rats with induced keratomycosis. These results confirmed capabilities a nanocarrier ocular diseases topically.

Язык: Английский

Процитировано

23
Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin infection; D-optimal optimization, ex-vivo, in-silico, and in-vivo studies DOI

Moaz M. El-Naggar,

Mohamed A. El-Nabarawi, Mahmoud H. Teaima

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 633, С. 122621 - 122621

Опубликована: Янв. 21, 2023

Язык: Английский

Процитировано

16
Enhanced Wound Healing Potential of Spirulina platensis Nanophytosomes: Metabolomic Profiling, Molecular Networking, and Modulation of HMGB-1 in an Excisional Wound Rat Model DOI Creative Commons
Hanan Refai, Amira A. El-Gazar, Ghada M. Ragab

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(3), С. 149 - 149

Опубликована: Фев. 24, 2023

Excisional wounds are considered one of the most common physical injuries. This study aims to test effect a nanophytosomal formulation loaded with dried hydroalcoholic extract S. platensis on promoting excisional wound healing. The Spirulina (SPNP) containing 100 mg PC and 50 CH exhibited optimum physicochemical characteristics regarding particle size (598.40 ± 9.68 nm), zeta potential (-19.8 0.49 mV), entrapment efficiency (62.76 1.75%), Q6h (74.00 1.90%). It was selected prepare an HPMC gel (SPNP-gel). Through metabolomic profiling algal extract, thirteen compounds were identified. Molecular docking identified active site HMGB-1 protein revealed that 12,13-DiHome had highest score -7.130 kcal/mol. SPNP-gel showed higher closure enhanced histopathological alterations as compared standard (MEBO® ointment) in wounded Sprague-Dawley rats. Collectively, NPS promoted healing process by enhancing autophagy (LC3B/Beclin-1) NRF-2/HO-1antioxidant pathway halting inflammatory (TNF-, NF-κB, TlR-4 VEGF), apoptotic processes (AIF, Caspase-3), downregulation HGMB-1 expression. present study's findings suggest topical application possesses therapeutic healing, chiefly downregulating

Язык: Английский

Процитировано

14
Lomefloxacin-loaded PLGA hollow nanospheres for healing MRSA-infected diabetic wound; optimization, in vitro and in vivo studies DOI
Rana M. Gebreel, Menna M. Abdellatif,

A El-Gedawy Attia

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106050 - 106050

Опубликована: Авг. 8, 2024

Язык: Английский

Процитировано

5
Sonophoresis mediated diffusion of caffeine loaded Transcutol® enriched cerosomes for topical management of cellulite DOI Creative Commons
Rofida Albash, Manar Adel Abdelbari,

Rovan M. Elbesh

и другие.

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 201, С. 106875 - 106875

Опубликована: Авг. 8, 2024

The goal of this research was to augment the deposition caffeine loaded Transcutol® enriched cerosomes (TECs) gel for efficient topical treatment cellulite utilizing sonophoresis technique. Caffeine-loaded TECs were prepared using thin film hydration method applying 2

Язык: Английский

Процитировано

5
Tanshinone IIA loaded bioactive nanoemulsion for alleviation of lipopolysaccharide induced acute lung injury via inhibition of endothelial glycocalyx shedding DOI Open Access
Riham M. El‐Moslemany,

Amal H. El‐Kamel,

Eman Allam

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113666 - 113666

Опубликована: Сен. 12, 2022

Acute lung injury (ALI) and its more serious form; acute respiratory distress syndrome are major causes of COVID-19 related mortality. Finding new therapeutic targets for ALI is thus great interest. This work aimed to prepare a biocompatible nanoformulation effective pulmonary delivery the herbal drug; tanshinone-IIA (TSIIA) management. A nanoemulsion (NE) formulation based on bioactive natural ingredients; rhamnolipid biosurfactant tea-tree oil, was developed using simple ultrasonication technique, optimized by varying oil concentration surfactant:oil ratio. The selected TSIIA-NE showed 105.7 nm diameter PDI ∼ 0.3. EE exceeded 98 % with biphasic sustained drug release good stability over 3-months. In-vivo efficacy evaluated in lipopolysaccharide (LPS)-induced model. (30 µg/kg) administered once intratracheally 2 h after LPS instillation. Evaluation performed 7days post-treatment. Pulmonary function assessment, inflammatory, oxidative stress glycocalyx shedding markers analysis addition histopathological examination tissue were performed. When compared untreated rats, in-vivo study demonstrated 1.4 1.9-fold increases tidal volume minute volume, respectively, 32 drop wet/dry weight ratio improved levels arterial blood gases. Lung histopathology biochemical different biomarkers homogenate bronchoalveolar lavage fluid indicated that treatment may ameliorate LPS-induced symptoms thorough anti-oxidative, anti-inflammatory effects inhibition degradation. superior free medication blank-NE. enhanced TSIIA significantly suggests pharmacotherapeutic potential as promising nanoplatform ALI.

Язык: Английский

Процитировано

20
Influence of the EPD route and surface preparation of titanium substrates on the microstructure, surface topography and usage properties of chitosan coatings incorporated in Tea Tree Oil and Terpinen-4-ol DOI Creative Commons
Mikołaj Mielczarek, Jakub Marchewka, Alicja Łukaszczyk

и другие.

Applied Surface Science, Год журнала: 2024, Номер 655, С. 159626 - 159626

Опубликована: Фев. 6, 2024

The electrophoretic deposition (EPD) of Tea Tree Oil (TTO)/chitosan and Terpinen-4-ol/chitosan coatings on titanium substrates with different surface preparations was examined. performed vertical horizontal configurations electrodes, called EPD, respectively, following the direction electric field. data obtained showed influence both electrode configuration substrate preparation EPD process as well coating properties, such adhesion, morphology, microstructure, roughness, topography wettability. most promising were for ground substrates. They relatively homogeneous consisted droplets TTO or Terpinen-4-ol embedded in chitosan. formation hydrogen bonds between chitosan chains detected responsible mechanism indicated. exhibited high adhesion strength, low wettability medium roughness. Both improved corrosion resistance Hanks' solution. This work that natural chitosan-based incorporated are antimicrobial protection titanium. surfaces has shown favorable antibacterial but it is interesting can be combined to further increase this potential, besides, they had highest biocompatibility.

Язык: Английский

Процитировано

4