International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2263 - 2263
Опубликована: Фев. 13, 2024
Organometallic
drug
development
is
still
in
its
early
stage,
but
recent
studies
show
that
organometallics
having
iron
as
the
central
atom
have
possibility
of
becoming
good
candidates
because
an
important
micro-nutrient,
and
it
compatible
with
many
biological
systems,
including
human
body.
Being
eco-friendly
Lewis
acid,
can
accept
lone
pair
electrons
from
imino(sp2)-nitrogen,
resultant
iron-imine
complexes
a
interacting
several
proteins
enzymes
humans.
Iron-imine
demonstrated
significant
potential
anticancer,
bactericidal,
fungicidal,
other
medicinal
activities
years.
This
article
systematically
discusses
major
synthetic
methods
pharmacological
potentials
vitro
activity
to
clinical
performance
2016
date.
In
nutshell,
this
manuscript
offers
simplistic
view
inorganic
chemistry:
for
instance,
presented
"eco-friendly
non-toxic"
metal
(as
opposed
platinum)
will
lead
non-toxic
pharmaceuticals.
The
abundant
literature
on
chelators
shows
complexes,
particularly
if
redox-active
cells,
be
quite
cytotoxic,
which
beneficial
future
targeted
therapies.
While
we
made
every
effort
include
all
related
papers,
any
omission
purely
unintentional.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Март 18, 2024
Introduction:
Cancer,
a
significant
global
health
concern,
necessitates
innovative
treatments.
The
pivotal
role
of
chronic
inflammation
in
cancer
development
underscores
the
urgency
for
novel
therapeutic
strategies.
Benzothiazole
derivatives
exhibit
promise
due
to
their
distinctive
structures
and
broad
spectrum
biological
effects.
This
study
aims
explore
new
anti-tumor
small
molecule
drugs
that
simultaneously
anti-inflammatory
anticancer
based
on
advantages
benzothiazole
frameworks.
Methods:
compounds
were
characterized
by
nuclear
magnetic
resonance
(NMR),
liquid
chromatograph-mass
spectrometer
(LC-MS)
high
performance
chromatography
(HPLC)
structure
as
well
purity
other
related
physicochemical
properties.
effects
proliferation
human
epidermoid
carcinoma
cell
line
(A431)
non-small
lung
lines
(A549,
H1299)
evaluated
MTT
method.
effect
expression
levels
inflammatory
factors
IL-6
TNF-α
mouse
monocyte
macrophages
(RAW264.7)
was
assessed
using
enzyme-linked
immunosorbent
assay
(ELISA).
apoptosis
cycle
A431
A549
cells
flow
cytometry.
migration
scratch
wound
healing
assay.
protein
Western
Blot
parameters,
pharmacokinetic
properties,
toxicity
drug
similarity
active
compound
predicted
Swiss
ADME
admetSAR
web
servers.
Results:
Twenty-five
designed
synthesized,
with
confirmed
through
spectrogram
verification.
6-chloro-
N
-(4-nitrobenzyl)
benzo[d]
thiazol-2-amine
(compound
B7
)
screened
series
bioactivity
assessments,
which
significantly
inhibited
A431,
H1299
cells,
decreased
activity
TNF-α,
hindered
migration.
In
addition,
at
concentrations
1,
2,
4
μM,
exhibited
apoptosis-promoting
cycle-arresting
similar
those
lead
7-chloro-
-(2,
6-dichlorophenyl)
thiazole-2-amine
4i
).
blot
analysis
both
AKT
ERK
signaling
pathways
cells.
prediction
results
ADMET
indicated
had
good
Discussion:
has
innovatively
developed
derivatives,
focus
its
notable
dual
activities.
stands
out
ability
reduce
A549,
lower
cytokines
TNF-α.
These
position
promising
candidate
dual-action
therapy.
study’s
mechanistic
exploration,
highlighting
’s
simultaneous
inhibition
pathways,
offers
strategy
addressing
survival
mechanisms
tumor
milieu
facilitating
progression.
RSC Advances,
Год журнала:
2025,
Номер
15(10), С. 7571 - 7608
Опубликована: Янв. 1, 2025
Benzimidazole,
a
fused
bicyclic
compound
with
benzene
and
pentacyclic
1,3-diazole
moeities,
has
simple
aromatic
heterocyclic
structure.
The
moiety
become
an
indispensable
anchor
for
the
development
of
new
pharmacologically
active
products,
yielded
several
therapeutic
agents
anticancer,
antihypertensive,
antimicrobial,
antifungal
antiulcer
effects.
Benzimidazoles,
as
synthetically
feasible
pharmacophoric
synthons,
have
been
relentlessly
pursued
preparation
analogues
derivatives,
they
successfully
developed
into
some
most
sought-after
vital
pharmacophores
drug
discovery.
use
varied
substituents
differing
patterns
around
benzimidazole
nucleus
provided
wide
spectrum
biological
activities.
In
addition,
constitutes
building
block
production
drugs,
candidates,
chemical
entities,
lead
molecules.
importance
this
bioactivity,
e.g.,
antibacterial,
antitubercular,
antidiabetic,
antifungal,
anti-inflammatory,
analgesic,
antioxidant,
antihistaminic,
antimalarial
activity,
led
us
to
take
note
provide
overview
synthetic
approaches
various
derivatives
together
their
actions.
This
review
is
projected
further
assist
in
design
benzimidazole-based
compounds
optimized
products
towards
drug-development
strategies.
Inorganics,
Год журнала:
2025,
Номер
13(4), С. 109 - 109
Опубликована: Апрель 1, 2025
In
order
to
design
antimicrobial
species,
a
series
of
methacrylate
(Macr)
complexes,
[Cu(HBzIm)2(Macr)2]
(1),
[Cu2(HBzIm)2(Macr)4]
(2),
[Cu(2-MeBzIm)2(Macr)2]
(3),
[Cu2(2-MeBzIm)2(Macr)4]
(4),
and
[Cu(5,6-Me2BzIm)2(Macr)2]
(5)
(HBzIm
=
benzimidazole,
2-MeBzIm
2-methylbenzimidazole,
5,6-Me2BzIm
5,6-dimethylbenzimidazole)
were
synthesized
characterized
by
several
spectral
techniques,
as
well
single
crystal
X-ray
diffraction.
The
mononuclear
species
exhibit
distorted
octahedral
stereochemistry,
while
the
binuclear
types,
with
paddle-wheel
structure,
adopt
square
pyramidal
surrounding.
acts
either
chelate
or
bridge,
all
benzimidazole
derivatives
are
coordinated
unidentate.
supramolecular
networks
developed
both
intermolecular
π–π
stacking
interactions
hydrogen
bonds.
assays
provided
complexes
ability
inhibit
planktonic
strain
proliferation,
adhere
on
inert
substratum.
All
moderate
activity,
in
regards
standard
clinical
isolate
strains,
most
active
being
compound
5
against
Candida
albicans,
minimum
inhibitory
concentration
(MIC)
0.156
mg/mL.
It
is
worth
mentioning
that
complex
1
inhibited
microbial
adhesion
Escherichia
coli
2
constrained
C.
albicans
strain.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(5)
Опубликована: Апрель 10, 2025
ABSTRACT
In
this
study,
N‐phenylortho‐phenylenediamine
and
N‐phenyl
ethylenediamine
were
utilized
as
amines,
two
novel
ligands,
benzimidazole
(LI)
Schiff
base
(LII),
synthesized
through
condensation
reactions
with
3‐methoxy‐4‐benzyloxybenzaldehyde.
Furthermore,
using
these
same
LIII
(benzimidazole)
3‐phenoxybenzaldehyde
LIV
(Schiff
base)
4‐benzyloxybenzaldehyde
in
accordance
the
literature.
Then,
Pt
(II)
complexes
(Ia,
Ib,
II,
III,
IV)
prepared
it
was
determined
that
Ia
Ib
are
geometric
isomers.
The
ligands
characterized
1
H‐NMR,
13
C‐NMR,
FT‐IR,
elemental
analysis
methods.
cytotoxic
effects
of
evaluated
on
SH‐SY5Y
neuronal
cells.
Low‐toxicity
Ia,
IV
then
tested
for
their
ability
to
inhibit
amyloid
beta
(Aβ
1–42
)
aggregation.
Thioflavin
T
fluorescence
analysis,
AFM
imaging,
MALDI‐TOF
mass
spectrometry
demonstrated
complexes,
particularly
at
a
1:1
complex‐to‐amyloid
molar
ratio,
effectively
inhibited
Aβ
These
findings
suggest
containing
may
be
effective
against
Alzheimer's
disease
by
alleviating
toxicity.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 484 - 484
Опубликована: Янв. 18, 2024
Indole
is
an
important
element
of
many
natural
and
synthetic
molecules
with
significant
biological
activity.
Nonetheless,
the
co-presence
transitional
metals
in
organic
scaffold
may
represent
factor
development
effective
medicinal
agents.
This
review
covers
some
latest
most
relevant
achievements
pharmacological
activity
indole-containing
metal
complexes
area
drug
discovery.
Energy & Fuels,
Год журнала:
2024,
Номер
38(10), С. 8481 - 8515
Опубликована: Апрель 24, 2024
CO2
is
an
important
component
of
the
atmosphere
that
helps
in
balancing
Earth's
atmospheric
temperature
and
channelizes
food
cycles.
However,
increase
or
decrease
concentration
will
severely
affect
climate.
Particularly,
rise
levels
has
immensely
contributed
to
global
warming,
resulting
elevated
temperature,
altered
precipitation
patterns,
glacier
melting,
subsequent
rises
sea
levels,
impacting
human
well-being.
In
response,
researchers
are
exploring
strategies
capture
convert
into
valuable
products,
such
as
methanol,
formic
acid,
organic
compounds.
synthesis
compounds
using
CO2,
like
benzimidazole
quinazolines,
a
high
impact.
Benzimidazole,
widely
used
medicinal
chemistry
for
treating
cancer
stomach
ulcers,
also
exhibits
antiviral
antifungal
properties.
Quinazoline
derivatives,
essential
drugs
prazosin
doxazosin,
have
applications
post-traumatic
stress
disorder
Alzheimer's
disease.
These
were
synthesized
mainly
environmentally
harmful
synthons
phosgene
potassium
cyanide.
To
address
both
environmental
health
concerns,
delving
chemical
fixation
sustainable
green
production.
Catalysis
emerges
key
principle
chemistry,
with
catalysts
reducing
activation
energy
facilitating
processes.
This
review
discusses
recent
state
art
on
development
various
conversion
quinazoline
benzimidazole,
through
homogeneous
heterogeneous
catalysts.
Notably,
while
lack
industrial
recyclability,
show
promise
large-scale
implementation.
comprehensive
mechanistic
aspects
DFT
studies
understanding
better.
Toward
end,
it
gives
future
scope
this
subject.
RSC Advances,
Год журнала:
2025,
Номер
15(2), С. 739 - 747
Опубликована: Янв. 1, 2025
Given
that
stomach
cancer
is
the
fourth
leading
cause
of
cancer-related
death,
there
a
need
to
develop
new
drugs.
Among
various
methods,
metal-based
coordination
compounds
are
considered
as
an
efficient
strategy
against
this
type
cancer.
Similarly,
benzimidazole
moiety
plays
crucial
role
in
biology;
thus,
benzimidazole-based
have
been
found
be
active
potential
anticancer
drugs
and
currently
used
clinical
trials.
In
study,
we
explored
cobalt(ii)
complex
agent
AGS
cell
lines.
Interestingly,
MTT
assay
Co-NTB
shows
lower
IC
