International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2263 - 2263
Опубликована: Фев. 13, 2024
Organometallic
drug
development
is
still
in
its
early
stage,
but
recent
studies
show
that
organometallics
having
iron
as
the
central
atom
have
possibility
of
becoming
good
candidates
because
an
important
micro-nutrient,
and
it
compatible
with
many
biological
systems,
including
human
body.
Being
eco-friendly
Lewis
acid,
can
accept
lone
pair
electrons
from
imino(sp2)-nitrogen,
resultant
iron-imine
complexes
a
interacting
several
proteins
enzymes
humans.
Iron-imine
demonstrated
significant
potential
anticancer,
bactericidal,
fungicidal,
other
medicinal
activities
years.
This
article
systematically
discusses
major
synthetic
methods
pharmacological
potentials
vitro
activity
to
clinical
performance
2016
date.
In
nutshell,
this
manuscript
offers
simplistic
view
inorganic
chemistry:
for
instance,
presented
"eco-friendly
non-toxic"
metal
(as
opposed
platinum)
will
lead
non-toxic
pharmaceuticals.
The
abundant
literature
on
chelators
shows
complexes,
particularly
if
redox-active
cells,
be
quite
cytotoxic,
which
beneficial
future
targeted
therapies.
While
we
made
every
effort
include
all
related
papers,
any
omission
purely
unintentional.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Abstract
An
efficient
I
2
‐promoted
Povarov
multicomponent
reaction
for
the
synthesis
of
2,2′‐biquinolines
or
N
‐heteroaromatic
benzothiazole
using
2‐methylquinoline
2‐methylbenzo[
d
]thiazole,
arylamines,
and
α
‐ketoesters
was
developed.
The
methyl
group
aza‐arenes
incorporated
in
via
an
iodination/Kornblum
oxidation
sequence.
This
method
achieved
through
a
one‐pot
two‐step
process
without
need
transition
metals,
demonstrating
excellent
scalability
synthesis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2263 - 2263
Опубликована: Фев. 13, 2024
Organometallic
drug
development
is
still
in
its
early
stage,
but
recent
studies
show
that
organometallics
having
iron
as
the
central
atom
have
possibility
of
becoming
good
candidates
because
an
important
micro-nutrient,
and
it
compatible
with
many
biological
systems,
including
human
body.
Being
eco-friendly
Lewis
acid,
can
accept
lone
pair
electrons
from
imino(sp2)-nitrogen,
resultant
iron-imine
complexes
a
interacting
several
proteins
enzymes
humans.
Iron-imine
demonstrated
significant
potential
anticancer,
bactericidal,
fungicidal,
other
medicinal
activities
years.
This
article
systematically
discusses
major
synthetic
methods
pharmacological
potentials
vitro
activity
to
clinical
performance
2016
date.
In
nutshell,
this
manuscript
offers
simplistic
view
inorganic
chemistry:
for
instance,
presented
"eco-friendly
non-toxic"
metal
(as
opposed
platinum)
will
lead
non-toxic
pharmaceuticals.
The
abundant
literature
on
chelators
shows
complexes,
particularly
if
redox-active
cells,
be
quite
cytotoxic,
which
beneficial
future
targeted
therapies.
While
we
made
every
effort
include
all
related
papers,
any
omission
purely
unintentional.
