Antioxidant and Antidiabetic Activity of Cornus mas L. and Crataegus monogyna Fruit Extracts
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3595 - 3595
Опубликована: Июль 30, 2024
The
present
study
evaluated
three
green
extraction
methods,
accelerated
solvent
(ASE),
ultrasound-assisted
(UAE),
and
laser
irradiation
(LE),
for
the
polyphenolic
compounds
vitamin
C
of
Язык: Английский
Phenolic Composition of Crataegus monogyna Jacq. Extract and Its Anti-Inflammatory, Hepatoprotective, and Antileukemia Effects
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 786 - 786
Опубликована: Июнь 15, 2024
Crataegus
monogyna
(C.
monogyna)
is
a
prominent
plant
used
in
Moroccan
traditional
medicine.
This
study
investigated
the
phenolic
composition
and
anti-inflammatory,
hepatoprotective,
anticancer
activities
of
hydroethanolic
extract
C.
leaves
stems.
Ultra-high-performance
liquid
chromatography
identified
profile.
The
vitro
activity
was
evaluated
using
MTT
assay
on
HL-60
K-562
myeloleukemia
cells
liver
(Huh-7)
cell
lines.
anti-inflammatory
effect
assessed
vivo
carrageenan-induced
paw
edema
rats.
hepatoprotective
at
300
1000
mg/kg
doses
against
acetaminophen-induced
hepatotoxicity
rats
studied
for
seven
days.
Additionally,
molecular
docking
simulations
were
performed
to
evaluate
extract’s
inhibitory
potential
key
targets:
lipoxygenase,
cytochrome
P450,
tyrosine
kinase,
TRADD.
exhibited
significant
cytotoxic
cells,
but
not
lung
cancer
(Huh-7
line).
dose
demonstrated
most
potent
effect,
inhibiting
by
99.10%
after
6
h.
displayed
promising
properties.
Procyanidin
(−7.27
kcal/mol),
quercetin
(−8.102
catechin
(−9.037
kcal/mol)
as
active
molecules
respectively.
These
findings
highlight
untapped
further
exploration
treating
damage,
inflammation,
leukemia.
Язык: Английский
Bioactive Compounds and Antimicrobial Activities in Iranian Crataegus persica Ecotypes for Potential Food and Medicinal Uses
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 1, 2025
The
genus
Язык: Английский
Assessment of genetic diversity by multivariate analysis in Turkish Hawthorn (Crataegus azarolus) genetic resources
Genetic Resources and Crop Evolution,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
Abstract
Due
to
its
diverse
climatic
conditions,
Türkiye
provides
a
suitable
environment
for
the
cultivation
of
many
fruit
species.
This
study
focused
on
natural
hawthorn
(
Crataegus
azarolus
),
one
these
species,
select
94
different
genotypes
collected
from
populations
in
and
determine
their
molecular
morphological
characteristics.
A
significant
variation
was
observed
among
terms
analyzed
traits.
According
results
using
inter
simple
sequence
repeat
(ISSR)
marker
system,
178
polymorphic
bands
were
obtained
12
primers
(Invitrogen
Life
Technologies,
USA),
polymorphism
rate
determined
be
100%.
The
similarity
index
ranged
0.40
0.93,
completely
differentiated
another.
In
characteristics,
there
considerable
genotypes:
width
8.96
mm
(genotype
72)
29.75
101),
length
9.19
24.86
weight
0.45
12.42
g.
foundation
developing
that
will
offer
high
productivity
while
conserving
water
soil
resources
arid
semi-arid
regions
by
revealing
degree
genetic
characteristics
adapted
ecological
conditions
Türkiye.
Furthermore,
demonstrates
with
superior
traits
can
utilized
as
material
breeding
programs,
medical
research,
development
new
cultivars.
Язык: Английский
Natural Diversity of Crataegus monogyna Jacq. in Northeastern Türkiye Encompassing Morphological, Biochemical, and Molecular Features
Horticulturae,
Год журнала:
2025,
Номер
11(3), С. 238 - 238
Опубликована: Фев. 24, 2025
Hawthorn
(Cratageus
monogyna
Jacq.),
one
of
the
important
wild
fruit
species
in
Turkey,
is
an
many
countries
due
to
its
use
traditional
medicine,
landscaping
studies,
and
food
beverage
industry.
In
this
study,
morphological
characterization
revealed
significant
variation
among
genotypes,
with
weight
ranging
from
0.55
g
2.87
g,
width
9.74
mm
18.39
mm,
leaf
19.53
41.19
mm.
Genotype-dependent
variations
were
observed
total
phenolic
content
(151.34
mg–491.88
mg
GAE
100
g−1
flesh),
flavonoid
(16.74–48.13
CAE
anthocyanin
(26.34–79.79
cyn-3
gluc
antioxidant
activity
(29.20%
56.70%).
HPLC-based
profiling
identified
substantial
key
bioactive
compounds,
highest
levels
chlorogenic
acid
(16.16
fw),
caffeic
(10.21
epicatechin
(13.83
rutin
(74.05
protocatechuic
(2.00
fw).
ISSR
marker-based
molecular
analysis
a
high
degree
genetic
polymorphism
(89.12%),
55
out
62
bands
classified
as
polymorphic.
The
polymorphic
information
values
ranged
0.34
0.44.
Jaccard
similarity
coefficient
0.04
(M9
M16)
0.63
(M17
M3),
indicating
variability.
tanglegram
comparing
morphological–biochemical
dendrograms
yielded
entanglement
score
0.714,
alignment
between
phenotypic
data.
These
findings
show
that
hawthorn
genotypes
Kelkit
Valley
exhibit
extensive
biochemical
diversity,
which
critical
for
conservation
efforts,
breeding
programs,
development
high-value
medicinal
functional
products.
Язык: Английский
Investigation of Algerian Crataegus monogyna Jacq Phenolic Compounds (Using LC-ESI-MS/MS Analysis, Antioxidant Activity, and Enzyme Inhibition) and Their Potential Implications for Food and Nutraceutical Applications
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1350 - 1350
Опубликована: Ноя. 4, 2024
Investigations
into
the
phenolic
constituents
of
butanolic
fraction
Crataegus
monogyna
were
optimized
using
LC-ESI-MS/MS
analysis,
identifying
and
quantifying
at
least
23
fingerprint
phytochemical
compounds.
The
major
compounds
epicatechin
(99.916
±
2.208
mg/g),
isoquercetrin
(53.31
1.172
chlorogenic
acid
(47.457
1.010
quinic
(37.819
1.406
rutin
(29.98
0.740
hesperidin
(5.296
0.177
mg/g,
detected
for
first
time
in
C.
species),
astragalin
(1.774
0.020
nicotiflorin
(1.482
0.016
mg/g).
antioxidant
properties
lyophilized
evaluated
DPPH,
GOR,
ABTS,
CUPRAC,
reducing
power
assays,
all
which
demonstrated
that
there
was
strong
activity.
Additionally,
neuroprotective
effect
vitro,
showing
a
potent
inhibitory
on
acetylcholinesterase
(AChE)
with
an
IC50
43.65
2.10
µg/mL.
antidiabetic
investigated
through
α-amylase
inhibition
(IC50
=
91.19
0.10
µg/mL),
high
In
addition,
extract
exhibited
significant
urease
26.36
0.05
These
results
suggest
Algerian
has
potential
as
therapeutic
agent
managing
diabetes
complications
natural
source
AChE
inhibitors,
making
it
promising
subject
treatment
urease-related
conditions.
Its
concentrations
antioxidants,
such
epicatechin,
isoquercetrin,
acid,
rutin,
hesperidin,
astragalin,
make
suitable
integration
medicine,
pharmaceuticals,
cosmetics,
food
sector.
Язык: Английский
CRATAEGUS MONOGYNA JACQ. VE CRATAEGUS LAEVIGATA (POIR.) DC. KIRMIZI ALIÇ TÜRLERİNİN MEYVE, ÇEKİRDEK, SAP KISIMLARININ FİTOKİMYASAL VE ANTİOKSİDAN ÖZELLİKLER AÇISINDAN DEĞERLENDİRİLMESİ
GIDA / THE JOURNAL OF FOOD,
Год журнала:
2024,
Номер
49(4), С. 669 - 681
Опубликована: Июль 23, 2024
Yemişen,
diğer
adı
ile
kırmızı
alıç
(Crataegus
spp.)
Rosaceae
familyasına
ait
bir
bitki
olup
Dünya’da
ılıman
iklime
sahip
Asya,
Avrupa
ve
Kuzey
Amerika’nın
farklı
bölgelerinde
yetişmekte
aynı
zamanda
Türkiye’nin
de
yayılım
göstermektedir.
Meyveleri
beğenilerek
tüketilmekle
birlikte
bitkinin
yaprak
sapları,
fenolik
asitler
flavonoidler
gibi
antioksidan
biyoaktif
bileşenlerce
oldukça
zengindir.
Bu
çalışmada,
bölgelerinden
temin
edilen
iki
yemişen
türünün
fitokimyasal
özellikleri
araştırılmıştır.
Crataegus
monogyna
Jacq.
Ve
laevigata
(Poir.)
DC.
Yemişen
türlerine
meyve,
pulp,
çekirdek
saplarında
toplam
madde
(TFM)
içeriği
DPPH
radikal
süpürme
aktivitesi,
organik
asit
şeker
profili
mineral
dağılımları
belirlenmiştir.
Elde
sonuçlara
göre,
en
bol
bulunan
makro-mineral
K,
mikro-mineral
Fe,
hâkim
malik
baskın
fruktoz
olarak
Her
türünde
meyve
pulplarının
TFM
bakımından
zengin
olduğu
meyvenin
saplarının
ise
daha
yüksek
kapasiteye
Unveiling the Complexity of Herbal Medicine: Safety, Toxicity, and Regulatory Challenges
Опубликована: Янв. 1, 2024
Язык: Английский
Optimization of green ultrasound-assisted extraction of phenolic compounds from Crataegus laciniata leaves and assessing for antioxidant activity, enzyme inhibition, and UPLC-ESI-MS-MS guided identification of metabolites
Chemical Papers,
Год журнала:
2024,
Номер
78(18), С. 9325 - 9339
Опубликована: Окт. 22, 2024
Язык: Английский