Medicinal Chemistry, Год журнала: 2024, Номер 21(1), С. 11 - 31

Опубликована: Авг. 12, 2024

Thiophene is one of the most important heterocyclic scaffolds with notable pharmacological properties. and its derivatives are particular interest among sulphurcontaining heterocycles because their similarities to numerous natural synthetic compounds identified potential. The purpose this study extensively analyse pathways adopted for synthesising thiophene investigate various biological functions. A comprehensive review existing literature was conducted collect data pertaining methods that employed synthesis derivatives. search carried out through relevant databases, including work published in 2024. variety procedures were arranged, encompassing both traditional approaches like Gewald reaction contemporary ones microwave-assisted green synthesis. In addition, a compilation vitro vivo studies effects 50 distinct primary focus on activities such as anti-cancer, anti-inflammatory, antiprotozoal, antibacterial, antioxidant, antiviral Diverse methodologies have been derivatives, conventional modern methods. Furthermore, potential investigated, demonstrating broad range actions. Key structural elements necessary activity clarified by investigations structure-activity relationship. flexible make them attractive candidates use medicinal pharmaceutical chemistry. Understanding different actions may assist rational design create novel treatments conditions. these be further explored optimised considerable next drug development initiatives.

Язык: Английский