Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery
Life Sciences,
Год журнала:
2025,
Номер
368, С. 123499 - 123499
Опубликована: Фев. 22, 2025
Язык: Английский
Human Plasma-Derived Exosomes: A Promising Carrier System for the Delivery of Hydroxyurea to Combat Breast Cancer
AAPS PharmSciTech,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 22, 2025
Язык: Английский
Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging
Advanced Drug Delivery Reviews,
Год журнала:
2025,
Номер
218, С. 115522 - 115522
Опубликована: Янв. 22, 2025
Язык: Английский
Improvement of drug release and its efficacy in cancer treatment with advanced encapsulation methods in a novel hydrophobic agent into human serum albumin nanoparticles
Results in Chemistry,
Год журнала:
2025,
Номер
unknown, С. 102156 - 102156
Опубликована: Фев. 1, 2025
Язык: Английский
Comparative Study on Drug Encapsulation and Release Kinetics in Extracellular Vesicles Loaded with Snake Venom L - amino acid oxidase
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Background
This
study
aimed
to
evaluate
the
potential
of
plasma-derived
extracellular
vesicles
(EVs)
as
drug
delivery
carriers
by
employing
two
drug-loading
techniques:
coincubation
and
freeze‒thaw
cycles.
Methods
EVs
isolated
via
polyethylene
glycol
(PEG)
precipitation
method
were
characterized
nanoparticle
tracking
analysis
(NTA)
transmission
electron
microscopy
(TEM).
The
size
particles
was
200.1
±
66.6
nm.
loaded
with
1000
µg/ml
snake
venom
L
amino
acid
oxidase
(SVLAAO)
subjected
cycles
prepare
a
novel
formulation.
encapsulation
efficiency
(EE)
analysed
at
30
60
minutes,
in
vitro
release
profiles
evaluated
for
both
methods
kinetic
model
same
determined.
Results
achieved
an
EE
58.08
0.060%
after
which
greater
than
that
(55.80
0.060%).
Drug
studies
demonstrated
93%
released
8.5
hours
method,
whereas
resulted
faster
(99%
6.5
hours)
due
membrane
disruption.
best
fit
value
(R
2)
highest
zero
order
kinetics
model.
Conclusion
In
conclusion,
preserves
EV
integrity,
enabling
sustained
release,
making
it
promising
strategy
targeted
applications.
highlights
innovative
therapeutic
delivery.
Язык: Английский
Cordycepin‐Loaded Dental Pulp Stem Cell‐Derived Exosomes Promote Aged Bone Repair by Rejuvenating Senescent Mesenchymal Stem Cells and Endothelial Cells
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 17, 2024
Aging
impairs
bone
marrow
mesenchymal
stem
cell
(BMSC)
functions
as
well
associated
angiogenesis
which
is
critical
for
regeneration
and
repair.
Hence,
repairing
defects
in
elderly
patients
poses
a
formidable
challenge
regenerative
medicine.
Here,
the
engineered
dental
pulp
cell-derived
exosomes
loaded
with
natural
derivative
of
adenosine
Cordycepin
(CY@D-exos)
are
fabricated
by
means
intermittent
ultrasonic
shock,
dually
rejuvenates
both
senescent
BMSCs
endothelial
cells
significantly
improve
repair
aged
animals.
CY@D-exos
can
efficiently
overcome
senescence
enhance
their
osteogenic
differentiation
activating
NRF2
signaling
maintaining
heterochromatin
stability.
Importantly,
also
potently
overcomes
vascular
promotes
angiogenesis.
In
vivo
injectable
gelatin
methacryloyl
(GelMA)
hydrogels
sustained
release
accelerate
injury
promote
new
blood
vessel
formation
Taken
together,
these
results
thus
demonstrate
that
cordycepin-loaded
display
considerable
potential
to
be
developed
next-generation
therapeutic
agent
promoting
Язык: Английский