A biochemical feedback signal for hypothermia treatment for neonatal hypoxic–ischemic encephalopathy: focusing on central nervous system proteins in biofluids
Frontiers in Pediatrics,
Год журнала:
2024,
Номер
12
Опубликована: Май 3, 2024
Hypothermia
has
been
widely
used
to
treat
moderate
severe
neonatal
hypoxic–ischemic
encephalopathy
(HIE),
yet
evaluating
the
effects
of
hypothermia
relies
on
clinical
neurology,
neuroimaging,
amplitude-integrated
electroencephalography,
and
follow-up
data
patient
outcomes.
Biomarkers
brain
injury
have
considered
for
estimating
hypothermia.
Proteins
specific
central
nervous
system
(CNS)
are
components
tissue,
once
CNS
is
damaged,
these
proteins
released
into
biofluids
(cerebrospinal
fluid,
blood,
urine,
tears,
saliva),
they
can
be
as
markers
damage.
Clinical
reports
shown
that
CNS-specific
marker
(CNSPs)
were
early
expressed
in
after
damage
formed
unique
biochemical
profiles.
As
a
result,
may
serve
an
indicator
screening
infants,
monitoring
disease
progression,
identifying
region
brain,
assessing
efficacy
neuroprotective
measures.
In
work,
we
found
there
few
using
CNSPs
biological
signals
HIE.
The
aim
this
article
review
classification,
origin,
composition,
physiological
function
with
changes
their
expression
levels
Hopefully,
will
improve
awareness
among
pediatricians,
encourage
future
studies
exploring
mechanisms
behind
CNSPs,
order
reduce
adverse
outcome
Язык: Английский
Comparative Brain Proteomic Analysis between Sham and Cerebral Ischemia Experimental Groups
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7538 - 7538
Опубликована: Июль 9, 2024
Sham
control
groups
are
essential
in
experimental
animal
studies
to
reduce
the
influence
of
surgical
intervention.
The
intraluminal
filament
procedure
is
one
most
common
models
middle
cerebral
artery
occlusion
(MCAO)
used
study
brain
ischemia.
However,
a
sham
group
usually
not
included
design
these
studies.
In
this
study,
we
aimed
evaluate
relevance
by
analyzing
and
comparing
protein
profiles
MCAO
groups.
group,
98
dysregulated
proteins
were
detected,
compared
171
ischemic
group.
Moreover,
comparative
revealed
existence
pool
57
that
appeared
be
both
animals.
These
results
indicated
required
for
(MCA)
induces
changes
expression
associated
with
lesions.
This
highlights
importance
including
design,
ensure
intervention
does
affect
therapeutic
target
under
study.
Язык: Английский