Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 104(10), С. 5660 - 5674

Опубликована: Фев. 28, 2024

Abstract Zinc, a crucial trace element is vital for the growth and development of humans. It frequently described as ‘the flower life’ source intelligence’. Zinc supplements play pivotal role in addressing zinc deficiency by serving this essential micronutrients, effectively replenishing depleted levels body. In paper, we first biological behavior human body briefly physiological phenomena associated with levels. The benefits drawbacks various supplement forms are then discussed, emphasis on most recent formulations. Finally, application food, medicine, animal husbandry further summarized. © 2024 Society Chemical Industry.

Язык: Английский

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Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 Therapy

Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(19), С. 12562 - 12593

Опубликована: Сен. 22, 2022

Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst. Alleviating overproduction reactive oxygen species cytokine storm in COVID-19 is essential to counteract the immunogenic damage endothelium alveolar membranes. Antioxidants alleviate oxidative stress, storm, hyperinflammation, diminish risk organ failure. Direct antiviral roles imply: impact on viral spike protein, interference with ACE2 receptor, inhibition dipeptidyl peptidase 4, transmembrane protease serine 2 or furin, helicase, papain-like protease, 3-chyomotrypsin like RNA-dependent RNA polymerase. Prooxidative environment favors conformational changes receptor binding domain, promoting affinity protein for host receptor. imply a vicious cycle, stress responses, vice versa. The same was noticed respect relationship antioxidant impairment-viral replication. Timing, dosage, activities, mutual influences, other antioxidants should be carefully regarded. Deficiency linked illness severity.

Язык: Английский

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The underlying mechanism behind the different outcomes of COVID-19 in children and adults

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has affected hundreds of millions people globally, resulting in deaths. During this pandemic, children have demonstrated greater resistance than adults, exhibiting lower infection rates, reduced mortality, and milder symptoms. Summarizing the differences between adults during COVID-19 can provide insights into protective mechanisms potential implications for future treatments. In review, we focused on summarizing discussing better protection COVID-19. These encompass several factors: baseline expression cell surface receptor ACE2 hydrolase TMPRSS2, impact complications COVID-19, age-related cytokine profiles. Additionally, local systemic immune responses also contribute significantly, particularly interferon responses, heterologous from non-COVID-19 vaccinations, status variations influenced micronutrient levels. The advantageous these may prevention treatment Importantly, while metabolic profiles differential vaccine to children, current comparative research remains limited requires further investigation.

Язык: Английский

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Significance of zinc deficiency correction for practical medicine: a review

Sechenov Medical Journal, Год журнала: 2023, Номер 13(4), С. 4 - 17

Опубликована: Март 15, 2023

Zinc deficiency is highly prevalent ranging from 10% to 30–40% of the population in developed and developing countries respectively. Low zinc level has been found be associated with 0.7% overall mortality 1.0% disability-adjusted life years (DALYs) worldwide. In turn, available research evidence shown that supplementation its can reduce risk preterm birth, promote physical development children, have certain protective effect against components metabolic syndrome. A positive on recovery pneumonia, diarrhea, common cold reported. It expected most pronounced may observed individuals subclinical or severe deficiency. Due high incidence deficiency, as well significant contribution a wide range pathologies, correction low considered economically effective strategy. Thus, results existing studies demonstrated efficiency intake for prophylaxis an adjuvant therapy pathologies.

Язык: Английский

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COVID-19 Excess Deaths in Peru’s 25 States in 2020: Nationwide Trends, Confounding Factors, and Correlations With the Extent of Ivermectin Treatment by State

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Авг. 8, 2023

Introduction In 2020, nations hastened to contain an emerging COVID-19 pandemic by deploying diverse public health approaches, but conclusive appraisals of the efficacy these approaches are elusive in most cases. One medicines deployed, ivermectin (IVM), a macrocyclic lactone having biochemical activity against SARS-CoV-2 through competitive binding its spike protein, has yielded mixed results randomized clinical trials (RCTs) for treatments. Peru, opportunity track IVM with close consideration confounding factors was provided data excess deaths as correlated use under semi-autonomous policies 25 states. Methods To evaluate possible treatment effects, determined from Peruvian national were analyzed state ages ≥60 Peru's These compared monthly summary Peru period 2020-2021 published WHO 2022. identify potential factors, Google mobility data, population densities, genetic variations, and seropositivity rates also examined. Results Reductions over 30 days after peak averaged 74% 10 states intensive use. As across all states, reductions closely extent (p<0.002). During four months before new president restricted use, there 14-fold reduction nationwide then 13-fold increase two following restriction Notably, trends align same Peru. Conclusions The natural experiment that put into motion authorization May using on locality sources, resulted strong evidence drug's effectiveness. Several including effects social isolation mandate imposed variations makeup virus, differences densities considered did not appear have significantly influenced outcomes.

Язык: Английский

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Alternative therapies for viral infections caused by SARS-Cov-2

Fisioterapia em Movimento, Год журнала: 2024, Номер 37

Опубликована: Янв. 1, 2024

Abstract Introduction The relevance of the studied topic lies in complexity treatment infection caused by SARS-CoV-2. Objective To discuss potential advantages and disadvantages alternative treatments compared to conventional medical approaches, highlight importance collaborative communication between patients healthcare providers making informed decisions about SARS-CoV-2 virus. Methods research methodology employed literature analysis methods, including bibliographic bibliosemantic approaches. study used theoretical, systematic, statistical analysis, synthesis, generalization, interpretation, classification, meta-analysis explore for infections, their interrelationships, trends incidence. Results identifies diverse therapies treating highlighting herbal medicine, acupuncture, reflexology, biohacking, homoeopathy, magnetotherapy. It underscores benefits remedies like garlic, ginger, chamomile, honeysuckle, as well vitamins (C, D, B12) minerals (zinc, selenium) managing COVID-19 symptoms. Conclusion While of-fering holistic benefits, these warrant cautious consideration due limited scientific backing interactions. Cultural understanding, patient-provider dialogue, choices are key harnessing medicine along-side approaches challenges.

Язык: Английский

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Deciphering the toxicity mechanism of haloquinolines on Chlorella pyrenoidosa using QSAR and metabolomics approaches

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 257, С. 114943 - 114943

Опубликована: Апрель 24, 2023

The hazardous potential of haloquinolines (HQLs) is becoming an issue great concern due to its wide and long-term usage in many personal care products. We examined the growth inhibition, structure-activity relationship, toxicity mechanism 33 HQLs on Chlorella pyrenoidosa using 72-h algal inhibition assay, three-dimensional quantitative relationship (3D-QSAR), metabolomics. found that IC50 (half maximal inhibitory concentration) values for compounds ranged from 4.52 > 150 mg·L-1, most tested were toxic (1 mg·L-1 < 10 mg·L-1) or harmful (10 100 aquatic ecosystem. Hydrophobic properties dominate their toxicity. Halogen atoms with large volume appear at 2, 3, 4, 5, 6, 7-positions quinoline ring significantly increase In cells, can block diverse carbohydrates, lipids, amino acid metabolism pathways, thereby resulting energy usage, osmotic pressure regulation, membrane integrity, oxidative stress disorder, thus fatally damaging cells. Therefore, our results provide insight into ecological risk HQLs.

Язык: Английский

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Some Doubts Vaccine Boosters, Vaccine Passports, and Prohibition to Use Antivirals Help with Cases and Fatalities of COVID-19 Infection

Indian Journal of Otolaryngology and Head & Neck Surgery, Год журнала: 2022, Номер 75(2), С. 1290 - 1293

Опубликована: Ноя. 6, 2022

Язык: Английский

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Explaining Why Africa had Much Lower COVID-19 Fatalities Per Million than Europe and North America

Coronaviruses, Год журнала: 2023, Номер 4(2)

Опубликована: Июнь 1, 2023

Abstract: This letter aims to explain the observed difference between COVID-19 fatalities in Europe and America compared Africa. At present (May 3, 2023), cumulative number of per million people has been 3,093 South America, 2,761 Europe, 2,662 North America. In particular, United States Kingdom had 3,323 3,320, respectively. With fewer opportunities practice social distancing or hygiene much more limited access health care, Africa only 181 million. The better performances have ascribed positive effects reduced hygiene, increased biome diversity, lack masking mandates restrictions, antivirals, a younger population, lower vaccination rates, which all may contributed against COVID-19.

Язык: Английский

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The different faces of inorganic elements in SARS-CoV-2 infection

Journal of Trace Elements in Medicine and Biology, Год журнала: 2022, Номер 74, С. 127083 - 127083

Опубликована: Сен. 21, 2022

Язык: Английский

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