Advanced NanoBiomed Research,
Год журнала:
2023,
Номер
3(12)
Опубликована: Ноя. 27, 2023
Nonspecific
immunotherapies
often
induce
general
immune
activation
or
suppression.
Conversely,
antigen‐specific
immunotherapy,
which
refers
to
dampening
augmenting
adaptive
immunity
against
a
disease‐specific
antigen,
increases
T‐cell
target
specificity
pathological
tissues,
thereby
reducing
side
effects
on
the
rest
of
system.
Advances
in
engineering
strategies
for
nanomaterials
have
enabled
feasible
modulation
their
physicochemical
features
incorporate
antigens
and
inherently
interact
with
innate
cells,
remarkably
amplifies
orchestration
responses
cancer
autoimmune
diseases.
From
this
contemporary
perspective,
basic
principles
immunotherapy
are
briefly
introduced
we
elucidate
how
latest
nanoengineering
paradigms
regulate
functions
heterogeneous
subsets
such
as
antigen‐presenting
B
regulatory
cytotoxic
T
promoting
treat
diseases
cancer.
An
outlook
prospects
remaining
challenges
been
discussed
for,
translating
scientific
discoveries
powerful
into
medical
advances
thus
offering
new
treatment
modalities
patients
unmet
needs.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(25)
Опубликована: Фев. 21, 2024
Abstract
Peptide‐based
supramolecular
therapeutics
(PST)
refer
to
those
theranostic
nanomedicines
based
on
peptide
or
derivatives
self‐assembly
that
are
constructed
in
vitro
vivo.
Benefiting
from
the
inherent
advantages
of
peptides,
such
as
good
biocompatibility,
high
bioactivity,
and
flexible
tunability,
reported
PST
have
shown
excellent
application
prospects
combating
many
major
diseases
including
cancer,
cardiovascular
disease,
infectious
autoimmune
metabolic
so
on.
Through
thoughtful
design,
can
be
fabricated
various
forms,
self‐assembled
precursor
molecules,
functional
nano‐assemblies,
macroscopic
large‐scale
hydrogels.
The
involved
peptides
play
different
roles,
serving
drug
carriers
for
effective
delivery,
acting
scaffold
materials
cell
culture,
functioning
bioactive
sequences
treating
diseases.
In
this
review,
a
comprehensive
overview
traditional
strategies
is
provided
build
emphasize
their
therapeutic
applications
fighting
pose
threat
human
life
health.
Moreover,
main
challenges
systems
application,
clinical
translation
also
briefly
discussed.
It
hoped
review
arouse
much
more
attention
paid
promote
its
practical
biomedical
field.
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
The
burden
of
Type
1
diabetes
(T1D)
is
vast
and
as
2021,
an
estimated
8.4
million
people
were
living
with
the
disease
worldwide.
Predictably,
this
number
could
increase
to
17.4
by
2040.
Despite
nearly
a
century
insulin
therapy
for
management
hyperglycemia
in
T1D,
no
therapies
exist
treat
its
underlying
etiopathology.
Adequate
dietary
intake
omega-3
fatty
acids
(ω-3)
has
been
reported
observational
studies
Randomized
Controlled
Trials
be
associated
reduced
risk
developing
T1D
but
results
have
inconclusive.
We
conducted
Mendelian
randomization
(MR)
study
explore
relationship
between
ω-3
T1D.
performed
two-sample
MR
analysis
using
single
nucleotide
polymorphisms
levels
sample
114,999
Europeans
their
effects
on
from
genome-wide
association
meta-analysis
24,840
European
participants.
A
main
Inverse-variance
weighted
(IVW)
method
was
validated
MR-Egger,
Weighted
median,
mode
methods.
Sensitivity
analyses
excluding
potentially
pleiotropic
also
performed.
Main
IVW
showed
evidence
causal
(OR:
0.92,
95%
CI:
0.56–1.51,
p
=
0.745).
MR-Egger
methods
similar
while
median
marginally
significant
1.15,
1.00–1.32,
0.048).
revealed
heterogeneity
estimates
(IVW
Q
>
100,
<
0.0001)
directional
pleiotropy
(Egger
intercept:
−0.032,
0.261).
Our
found
limited
only
observed
one
four
This
challenges
proposition
that
ω-3-rich
diets
are
substantial
benefit
prevention
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2144 - 2144
Опубликована: Март 21, 2025
Background:
Type
1
diabetes
(T1D)
is
a
chronic
autoimmune
disorder
characterized
by
the
destruction
of
pancreatic
β-cells,
leading
to
absolute
insulin
deficiency.
Despite
advancements
in
therapy
and
glucose
monitoring,
achieving
optimal
glycemic
control
remains
challenge.
Emerging
technologies
novel
therapeutic
strategies
are
transforming
landscape
T1D
management,
offering
new
opportunities
for
improved
outcomes.
Methods:
This
review
synthesizes
recent
treatment,
focusing
on
innovations
continuous
monitoring
(CGM),
automated
delivery
systems,
smart
formulations,
telemedicine,
artificial
intelligence
(AI).
Additionally,
we
explore
biomedical
approaches
such
as
stem
cell
therapy,
gene
editing,
immunotherapy,
gut
microbiota
modulation,
nanomedicine-based
interventions,
trace
element-based
therapies.
Results:
Advances
digital
health,
including
CGM
integration
with
hybrid
closed-loop
pumps
AI-driven
predictive
analytics,
have
significantly
real-time
management.
AI
telemedicine
enhanced
personalized
care
patient
engagement.
Furthermore,
regenerative
medicine
strategies,
β-cell
replacement,
CRISPR-based
immunomodulatory
therapies,
hold
potential
disease
modification.
Probiotics
microbiome-targeted
therapies
demonstrated
promising
effects
maintaining
metabolic
homeostasis,
while
elements
provide
additional
regulate
sensitivity
oxidative
stress.
Conclusions:
The
future
management
shifting
toward
precision
integrated
technological
solutions.
While
these
present
avenues,
challenges
long-term
efficacy,
safety,
accessibility,
clinical
validation
must
be
addressed.
A
multidisciplinary
approach,
combining
research,
intelligence,
nanotechnology,
will
essential
translate
into
practice,
ultimately
improving
quality
life
individuals
T1D.
Diabetes Obesity and Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Type
1
diabetes
mellitus
(T1DM)
is
an
autoimmune
disease
characterized
by
β-cell
damage
and
absolute
insulin
deficiency.
We
consider
combining
immune
intervention
replacement
biological
scaffold
to
treat
T1DM.
Zinc
transporter
8
(ZnT8)
known
be
a
pancreatic
islet-specific
autoantigen.
Studies
have
shown
that
ZnT8(107-115)/HLA-A2
dimers
can
used
as
antigen-specific
immunosuppressants
for
Mesenchymal
stem
cells
(MSCs)
induced
differentiate
into
insulin-producing
(IPCs)
under
certain
conditions
in
vitro.
In
recent
years,
the
development
of
biomaterials
has
provided
more
suitable
three-dimensional
microenvironment
cell
transplantation.
Our
research
group
previously
prepared
gelatin/polylactic
acid
(PLLA/G)
nanofiber
electrospinning
technology,
fixed
GLP-1
analogues
on
surface
modification
with
polydopamine
(pDA)
confirmed
promote
bone
mesenchymal
(BMSCs)
proliferation
improve
survival
rate.
addition,
differentiation
BMSCs
IPCs.
Subsequently,
dimer
was
constructed
loaded
inhibit
cytotoxicity
specific
CD8+
T
This
study
above
co-load
IPCs
implanted
T1DM
mice
blood
glucose
control
immunomodulatory
effects
First,
PLLA/G
modified
pDA
Liraglutide
(LIR)
obtain
PLLA/G-pDA-LIR
scaffold.
Rat
were
'three-step
induction
method'
induce
The
expression
detected
Dithizone
(DTZ)
staining,
stimulate
secretion
(GSIS)
vitro
intraperitoneal
tolerance
test
(IPGTT)
vivo.
Then,
non
obese
modelled
randomly
divided
5
groups.
Blank
not
treated;
negative
underwent
sham
surgery;
positive
injected
through
tail
vein;
single
load
subcutaneously
transplanted
IPCs;
double
dimer.
Blood
body
weight
measured
weekly
before
after
At
2,
4
6
W
transplantation,
some
taken
from
each
detect
serum
C-peptide,
spleen
lymphocyte
subsets
Tregs
Th1/Th2
inflammatory
factors.
results
differentiated
show
obtained
"three-step
method",
transplanting
effectively
reduce
tolerance.
Compared
non-scaffold
IPCs,
fixing
scaffolds
level
differentiation.
transplantation
showed
compared
group,
significantly
reduced,
C-peptide
increased
lasted
longer.
pathogenic
factors
anti-inflammatory
increased.
dual
functions
controlling
regulating
immunity,
may
Pediatrics & Neonatology,
Год журнала:
2024,
Номер
65(4), С. 395 - 398
Опубликована: Янв. 4, 2024
The
ZnT8
autoantibody
is
used
to
independently
diagnose
type
1
diabetes
(T1D)
and
as
a
prediction
factor
in
high-risk
populations.
This
the
first
report
Taiwan
on
prevalence,
diagnostic
utility,
clinical
characteristics
of
zinc
transporter
8
(ZnT8A)
children
with
T1D.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 14, 2024
Abstract
In
type
1
diabetes,
the
immune
system
destroys
pancreatic
beta
cells
in
an
autoimmune
condition.
To
overcome
this
disease,
a
specific
monoclonal
antibody
that
binds
to
could
be
used
for
targeted
immunotherapy.
Protein
tyrosine
phosphatase
receptor
N
(PTPRN)
is
one
of
important
surface
antigen
candidates.
Due
its
high
sequence
homology
among
mammals,
so
far,
no
single-chain
has
been
produced
against
receptor.
study,
we
developed
novel
variable
fragment
(scFv)
PTPRN
extracellular
domain.
aim,
ostrich
species
was
as
host
far
phylogenetically
birds
from
mammals
construct
phage
display
library
first
time.
An
ostrich-derived
scfv
prepared
and
biopanning
steps
were
done
enrich
screen
isolating
best
anti-PTPRN
binders.
scFv
with
appropriate
affinity
specificity
domain
selected
characterized
by
ELISA,
western
blotting,
flow
cytometry.
The
study
introduced
effective
tool
can
pave
way
creation
antibody-based
targeting
systems
cooperation
detection
therapy
I
diabetes.
Antibodies,
Год журнала:
2024,
Номер
13(2), С. 27 - 27
Опубликована: Апрель 1, 2024
Islet
autoantibodies
predict
type
1
diabetes
(T1D)
but
can
be
transient
in
murine
and
human
T1D
are
not
thought
to
directly
pathogenic.
Rather,
these
signal
B
cell
activity
as
antigen-presenting
cells
(APCs)
that
present
islet
autoantigen
diabetogenic
T
promote
pathogenesis.
Disrupting
APC
function
prevents
mouse
models
has
shown
promise
clinical
trials.
Autoantigen-specific
thus
hold
potential
sophisticated
biomarkers
therapeutic
targets.
receptor
(BCR)
somatic
hypermutation
is
a
mechanism
by
which
increase
affinity
for
autoantigen.
High-affinity
responses
selected
protective
immune
responses,
tolerance
mechanisms
known
censor
highly
autoreactive
clones
autoimmunity,
including
T1D.
Thus,
different
selection
rules
often
apply
autoimmune
disease
settings
(as
opposed
host
immunity),
where
ceilings
tolerated
based
on
variations
genetics
environment.
This
review
will
explore
what
currently
regarding
signaling,
selection,
interaction
with
