Deciphering the Role of Copper Homeostasis in Atherosclerosis: From Molecular Mechanisms to Therapeutic Targets
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11462 - 11462
Опубликована: Окт. 25, 2024
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
death
globally,
with
atherosclerosis
(AS)
playing
central
role
in
its
pathogenesis
as
chronic
inflammatory
condition.
Copper,
an
essential
trace
element
the
human
body,
participates
various
biological
processes
and
plays
significant
cardiovascular
system.
Maintaining
normal
copper
homeostasis
crucial
for
health,
dysregulation
balance
closely
associated
development
CVD.
When
disrupted,
it
can
induce
cell
death,
which
has
been
proposed
to
be
novel
form
"cuproptosis",
distinct
from
traditional
programmed
death.
This
new
linked
occurrence
progression
AS.
article
elaborately
describes
physiological
mechanisms
explores
interactions
signaling
pathways
related
Additionally,
we
focus
on
process
mechanism
induced
by
imbalances
summarize
relationship
between
homeostasis-related
genes
We
also
emphasize
potential
therapeutic
approaches,
such
regulators
nanotechnology
interventions,
adjust
levels
providing
ideas
strategies
prevention
treatment
Язык: Английский
Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 963 - 963
Опубликована: Апрель 15, 2025
Background/Objectives:
This
review
has
been
prepared
to
promote
interest
in
the
interdisciplinary
study
of
mitochondrial
dysfunction
(MD)
and
atherosclerosis.
aims
describe
state
this
problem
indicate
direction
for
further
implementation
knowledge
clinical
medicine.
Methods:
Extensive
research
literature
was
implemented
elucidate
role
molecular
mechanisms
MD
pathogenesis
Results:
A
view
on
atherosclerosis
through
prism
about
is
presented.
cause
primary
mechanism
onset
progression
It
proposed
that
be
considered
context
a
continuum.
Conclusions:
are
united
by
common
pathogenesis.
Knowledge
should
used
argue
healthy
lifestyle
as
way
prevent
The
development
new
approaches
diagnosing
treating
an
urgent
task
challenge
modern
science.
Язык: Английский
Reply to Klevay, L.M. Comment on “Huang et al. Influence of Varied Dietary Cholesterol Levels on Lipid Metabolism in Hamsters. Nutrients 2024, 16, 2472”
Nutrients,
Год журнала:
2025,
Номер
17(12), С. 1945 - 1945
Опубликована: Июнь 6, 2025
Thank
you
for
your
insightful
comments
and
suggestions
[...]
Язык: Английский
Comment on Huang et al. Influence of Varied Dietary Cholesterol Levels on Lipid Metabolism in Hamsters. Nutrients 2024, 16, 2472
Nutrients,
Год журнала:
2025,
Номер
17(12), С. 1944 - 1944
Опубликована: Июнь 6, 2025
Huang
et
al
[...]
Язык: Английский
Synthesis and characterization of biopolymer-based copper carbonate nanoparticles
Materials Today Communications,
Год журнала:
2024,
Номер
unknown, С. 111149 - 111149
Опубликована: Дек. 1, 2024
Язык: Английский
Impacts of Copper Deficiency on Oxidative Stress and Immune Function in Mouse Spleen
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 117 - 117
Опубликована: Дек. 30, 2024
Introduction:
Copper
is
an
essential
trace
element
crucial
for
enzyme
synthesis
and
metabolism.
Adequate
copper
levels
are
beneficial
maintaining
the
normal
immune
function
of
spleen.
deficiency
disrupts
metabolic
processes
within
spleen
impairs
its
function.
This
research
examines
impact
on
potential
recovery
following
supplementation.
Methods:
Weaned
mice
underwent
a
4-week
copper-deficient
diet,
succeeded
by
1-week
repletion
via
intraperitoneal
sulfate
injection.
Histological
examination
was
used
to
assess
pathological
changes
in
Biochemical
assays
were
performed
measure
oxidative
stress
ELISA,
qPCR,
Western
blot
employed
examine
alterations
inflammatory
markers,
indicators,
regulatory
factors
across
various
levels.
Results:
caused
histological
damage
spleen,
altered
expression
pathways
(Nrf2,
Keap1,
HO-1),
affected
key
enzymes
(iNOS,
COX2)
transcription
factor
NF-κB,
leading
damage.
reflected
decreased
SOD,
GSH,
T-AOC,
along
with
increased
CAT
MDA.
The
cytokines
IL-1β,
TNF-α,
IL-6,
IL-8
notably
increased.
supplementation
significantly
improved
these
changes.
Conclusions:
leads
tissue
mice,
affecting
Nrf2
pathway
inducing
Subsequent
effectively
ameliorates
deficiency.
Язык: Английский