Unveiling the geroprotective potential of Monarda didyma L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
Aging
is
driven
by
fundamental
mechanisms
like
oxidative
stress,
telomere
shortening
and
changes
in
DNA
methylation,
which
together
prepare
the
ground
for
age-related
diseases.
Botanical
extracts,
rich
bioactive
phytoconstituents,
represent
a
promising
resource
developing
therapies
that
target
these
to
promote
healthy
aging.
This
study
explores
geroprotective
potential
of
Monarda
didyma
L.
extract.
In
vitro
analyses
revealed
extract’s
strong
antioxidant
activity,
ability
reduce
shortening,
capacity
protect
against
damage,
thereby
decreasing
cellular
senescence
improving
endothelial
function.
The
randomized,
double-blind
clinical
trial
demonstrated
daily
oral
supplementation
with
extract
significantly
improved
leukocyte
length
(LTL)
stabilized
methylation
age
(DNAmAge)
intervention
group,
while
placebo
group
experienced
accelerated
epigenetic
aging
hypermethylation
critical
genes
(ELOVL2
FHL2).
also
reported
enhanced
quality
life,
particularly
physical
domain,
along
movement
sleep
indices
detected
questionnaire
wearable
sensors.
These
compelling
findings
position
as
powerful
candidate
future
therapies,
impact
Язык: Английский
Anthocyanin Extracts From 11 Superfruits Mitigate Oxidative Stress and Inflammatory Damage in HK‐2 Cells Induced by Cadmium Exposure
Food Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
ABSTRACT
Cadmium
(Cd)
pollution
has
emerged
as
an
escalating
threat
to
human
health,
with
its
induced
kidney
toxicity
being
closely
linked
oxidative
stress
and
inflammation.
In
this
study,
we
extracted
analyzed
primary
anthocyanins
from
11
superfruits
using
UPLC‐Triple‐TOF/MS
evaluated
their
antioxidant
capacity
through
DPPH,
ABTS,
FRAP,
ORAC
assays.
By
employing
a
Cd‐exposed
Human
Kidney‐2
(HK‐2)
cells
injury
model,
investigated
the
protective
effects
of
superfruit
anthocyanin
extracts.
The
results
demonstrated
that
these
extracts
enhanced
HK‐2
cell
viability,
increased
T‐SOD
GSH
levels,
reduced
ROS,
MDA,
NO.
Furthermore,
they
significantly
regulated
inflammation‐related
genes
proteins.
Moreover,
elucidated
mechanisms
by
which
mitigate
Cd‐induced
cellular
damage
via
classical
inflammatory
pathways.
These
findings
highlight
potential
specific
anthocyanin‐rich
fruits
in
reducing
Cd‐related
health
risks
suggest
practical
applications
for
bioactive
properties
promoting
health.
Язык: Английский