BMC Infectious Diseases,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 21, 2025
Sepsis-induced
coagulopathy
(SIC)
is
a
severe
complication
of
sepsis,
characterized
by
poor
prognosis
and
high
mortality.
However,
the
predictive
factors
for
development
SIC
in
sepsis
patients
remain
to
be
determined.
The
aim
this
study
was
develop
an
easy-to-use
efficient
nomogram
predicting
risk
developing
intensive
care
unit
(ICU),
based
on
common
indicators
complications
observed
at
admission.
A
total
12,
455
from
MIMIC
database
were
screened
randomly
divided
into
training
validation
cohorts.
In
cohort,
LASSO
regression
used
variable
selection
regularization.
selected
variables
then
incorporated
multivariable
logistic
model
construct
sepsis-induced
(SIC).
model's
performance
evaluated
using
area
under
receiver
operating
characteristic
curve
(AUC),
its
calibration
assessed
through
curve.
Additionally,
decision
analysis
(DCA)
performed
evaluate
clinical
applicability
model.
External
conducted
data
ICU
Xingtai
People's
Hospital.
Among
patients,
5,
145
(41.
3%)
developed
SIC.
occurrence
significantly
associated
with
SOFA
score,
red
blood
cell
count,
distribution
width
(RDW),
white
platelet
INR,
lactate
levels.
hypertension
identified
as
potential
protective
factor.
predict
SIC,
which
showed
AUC
0.
81
(95%
CI:
79-0.
83)
set,
83
82-0.
84)
79
74-0.
external
validation.
good
consistency
between
predicted
probabilities
novel
demonstrates
excellent
incidence
holds
promise
assisting
clinicians
early
identification
intervention
Not
applicable.
Annals of Intensive Care,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 24, 2024
Maintaining
tissue
perfusion
in
sepsis
depends
on
vascular
integrity
provided
by
the
endothelial
glycocalyx,
critical
layer
covering
luminal
surface
of
blood
vessels.
The
glycocalyx
is
composed
proteoglycans,
glycosaminoglycans,
and
functional
plasma
proteins
that
are
for
antithrombogenicity,
regulating
tone,
controlling
permeability,
reducing
interactions
with
leukocytes
platelets.
Degradation
substantial
due
to
thromboinflammation,
treatments
septic
shock
may
exacerbate
endotheliopathy
via
additional
injury.
As
a
result,
therapeutic
strategies
aimed
at
preserving
should
be
considered,
including
modifications
fluid
volume
resuscitation,
minimizing
catecholamine
use,
hyperglycemia,
potential
use
corticosteroids
anticoagulants.
In
this
review,
we
explore
treatment
aligned
recommendations
outlined
Surviving
Sepsis
Campaign
Guidelines
2021
special
emphasis
evidence
regarding
protection.
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2024,
Номер
44(3), С. 545 - 557
Опубликована: Янв. 18, 2024
Trauma
currently
accounts
for
10%
of
the
total
global
burden
disease
and
over
5
million
deaths
per
year,
making
it
a
leading
cause
morbidity
mortality
worldwide.
Although
recent
advances
in
early
resuscitation
have
improved
survival
from
critical
injury,
rate
patients
with
major
hemorrhage
approaches
50%
even
mature
trauma
systems.
A
determinant
clinical
outcomes
injury
is
complex,
dynamic
hemostatic
landscape.
Critically
injured
frequently
present
to
emergency
department
an
acute
traumatic
coagulopathy
that
increases
bleeding,
yet,
within
48
72
hours
after
will
switch
hypocoagulable
hypercoagulable
state
increased
risk
venous
thromboembolism
multiple
organ
dysfunction.
This
review
focus
on
role
platelets
these
processes.
As
effectors
hemostasis
thrombosis,
they
are
central
each
phase
recovery
our
understanding
postinjury
platelet
biology
has
dramatically
advanced
past
decade.
describes
current
knowledge
changes
behavior
occur
following
trauma,
mechanisms
by
which
develop,
implications
outcomes.
Importantly,
supported
research
other
settings,
this
also
reflects
emerging
thromboinflammation
including
cross
talk
between
platelets,
innate
immune
cells,
coagulation.
We
address
unresolved
questions
significant
gaps
remain,
finally
highlight
areas
further
study
help
deliver
improvements
care.
Journal of Intensive Care,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 13, 2025
The
incidence
of
heat-related
illnesses
and
heatstroke
continues
to
rise
amidst
global
warming.
Hyperthermia
triggers
inflammation,
coagulation,
progressive
multiorgan
dysfunction,
and,
at
levels
above
40
°C,
can
even
lead
cell
death.
Blood
cells,
particularly
granulocytes
platelets,
are
highly
sensitive
heat,
which
promotes
proinflammatory
procoagulant
changes.
Key
factors
in
pathophysiology
involve
mitochondrial
thermal
damage
excessive
oxidative
stress,
drive
apoptosis
necrosis.
While
the
kinetics
cellular
from
heat
have
been
extensively
studied,
mechanisms
driving
heat-induced
organ
death
not
yet
fully
understood.
Converse
hyperthermia,
hypothermia
is
generally
protective,
as
seen
therapeutic
hypothermia.
However,
accidental
presents
another
environmental
threat
due
arrhythmias,
cardiac
arrest,
coagulopathy.
From
a
physiology
perspective,
supports
homeostasis
enhances
preservation,
aiding
whole-body
recovery
following
resuscitation.
This
review
summarizes
recent
findings
on
temperature-related
preservation
suggests
future
research
directions
for
understanding
tempo-physiologic
axis.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 29, 2023
Venous
thromboembolism
is
a
very
common
and
costly
health
problem.
Deep-vein
thrombosis
(DVT)
can
cause
permanent
damage
to
the
venous
system
lead
swelling,
ulceration,
gangrene,
other
symptoms
in
affected
limb.
In
addition,
more
than
half
of
embolus
pulmonary
embolism
comes
from
thrombosis,
which
most
serious
death,
second
only
ischemic
heart
disease
stroke
patients.
It
be
seen
that
deep-vein
has
become
affecting
human
health.
recent
years,
with
deepening
research,
inflammatory
response
considered
an
important
pathway
trigger
thromboembolism,
transcription
factor
NF-κB
central
medium
inflammation,
signaling
regulate
pro-inflammatory
coagulation
response.
Thus,
explore
mechanism
make
use
it
may
provide
new
solutions
for
prevention
treatment
thrombosis.
