Phospholipid Nanoemulsion-Based Ocular Lubricant for the Treatment of Dry Eye Subtypes: A Multicenter and Prospective Study DOI Creative Commons

Maria Cristina Nishiwaki-Dantas,

Denise de Freitas,

Denise Oliveira Fornazari

и другие.

Ophthalmology and Therapy, Год журнала: 2024, Номер 13(12), С. 3203 - 3213

Опубликована: Ноя. 1, 2024

Dry eye disease (DED) is a multifactorial condition of the ocular surface (OS) characterized by loss tear film homeostasis, discomfort, and vision disturbances. Most available lubricants target aqueous deficiency tear, restoring only this layer, leaving lipid stratum deficient, as occurs in most patients with evaporative DED. An innovative propylene glycol-hydroxypropyl guar enriched phospholipid nanoemulsion (PG-HPG-PH-N) indicated to restore deficiencies both layers film, its composition was designed increase lubricant retention on OS. The purpose study evaluate, through Ocular Surface Disease Index (OSDI) clinical assessment, treatment who had DED due arising from mixed or subtypes PG-HPG-PH-N at reduced frequency twice day, prospective, multicenter, single-arm study. Patients were screened days − 7 0, day 1 (baseline first treatment) 28 lubricant. After visit (screening visit, 0), pre-treatment OS returned their research center 14 for complete including anamnesis, OSDI, corrected visual acuity, breakup time (TFBUT), staining evaluation, tolerability index, environmental exposure questionnaire. Seventy enrolled (60 women, 10 men), mean age 45 (range 27–64) years. TFBUT results showed an improvement stability vital dyes sodium fluorescein lysamine green decrease corneal after treatment. No significant adverse events reported, demonstrating good can be considered safe effective treating deficiency, subtypes. Brazilian National Research Ethics Commission (ReBEC registration number 16055).

Язык: Английский

Identification of Microplastics in Human Tear Fluid and Meibum: Implications for Dry Eye Disease Pathogenesis DOI Creative Commons
Jingyi Wang, Huanmin Kang,

Xixuan Huang

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137635 - 137635

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

2
Application of bioactive molecular networking to identify corneal-cytoprotective compounds from Dialium cochinchinense Pierre. leaves DOI Creative Commons
Thien Truong Nguyen-Ly, Yu‐Chi Lin,

Nguyen Tuan

и другие.

Current Plant Biology, Год журнала: 2025, Номер unknown, С. 100489 - 100489

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

1
Epidemiology and Risk Factors of Dry Eye Disease: Considerations for Clinical Management DOI Creative Commons
Alexis Ceecee Britten‐Jones, Michael T.M. Wang, Isaac Samuels

и другие.

Medicina, Год журнала: 2024, Номер 60(9), С. 1458 - 1458

Опубликована: Сен. 5, 2024

Dry eye disease is a multifactorial condition characterised by tear film instability, hyperosmolarity and ocular surface inflammation. Understanding the epidemiology of dry recognising both modifiable non-modifiable risk factors can assist care practitioners in assessing, treating, managing patients with condition. This review considers current knowledge surrounding its incidence prevalence, as well associated demographic, systemic, ocular, iatrogenic, lifestyle-related factors. Population-based prevalence estimates vary according to diagnostic criteria used define disease, severity demographic characteristics population. Considering recent data variable population demographics, conservative suggest that 10-20% over 40 years age report moderate severe symptoms and/or seek treatment for disease. Individuals specific may be at increased developing Advanced age, female sex East Asian ethnicity have been identified key features predisposing individuals Systemic conditions an include migraine, Sjögren syndrome, connective tissue disorders, mental health diabetes mellitus androgen deficiency. Medications contribute this antidepressants, antihistamines, hormone replacement therapy. Ocular iatrogenic blepharitis,

Язык: Английский

Процитировано

9
Efficacy and safety of transient receptor potential channel modulators for dry eye: A systematic review and meta-analysis DOI

Xiaohong Duan,

Mohan Ju, Xinquan Liu

и другие.

Contact Lens and Anterior Eye, Год журнала: 2025, Номер unknown, С. 102347 - 102347

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Efficacy of Eyelid Warming Devices as first-step treatment in Meibomian Gland Dysfunction: A systematic review with meta-analysis. DOI Creative Commons
Antonio Ballesteros‐Sánchez, Carlos Rocha‐de‐Lossada, José‐María Sánchez‐González

и другие.

The Ocular Surface, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
The impact of eyeliner usage on dry eye symptoms DOI Creative Commons
Yang Liu,

Yanru Shen,

Amy Gallant Sullivan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

1
Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model DOI Creative Commons
Chih-Chien Hsu, Hao-Kai Chuang, Yu‐Jer Hsiao

и другие.

Translational Vision Science & Technology, Год журнала: 2024, Номер 13(5), С. 13 - 13

Опубликована: Май 20, 2024

The purpose of this study was to conduct a large-scale genome-wide association (GWAS) and construct polygenic risk score (PRS) for stratification in patients with dry eye disease (DED) using the Taiwan Biobank (TWB) databases.

Язык: Английский

Процитировано

5
Recommendations for nutritional supplements for dry eye disease: current advances DOI Creative Commons

Ying Cong,

Yibing Zhang,

Yutong Han

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 30, 2024

Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact oral supplements, varying composition dosage, on symptoms DED. main components these supplements include fish oils (Omega-3 acids), vitamins, trace elements, phytochemical extracts. Beyond well-known nutrients, it necessary explore whether novel nutrients might contribute more management. This review provides comprehensive update therapeutic potential presents new perspectives combination treatment.

Язык: Английский

Процитировано

3
Tear Film Changes and Ocular Symptoms Associated with Soft Contact Lens Wear DOI Creative Commons

Eduardo Ínsua Pereira,

Madalena Lira, Paula Sampaio

и другие.

Vision, Год журнала: 2025, Номер 9(2), С. 27 - 27

Опубликована: Апрель 1, 2025

Discomfort is one of the leading causes associated with contact lens dropout. This study investigated changes in tear film parameters induced by wear and their relationship ocular symptomology. Thirty-four wearers (32.9 ± 9.1 years, 7 men) thirty-three non-lens (29.4 6.8 12 participated this clinical setting. Subjects were categorised into asymptomatic (n = 11), moderate 15), or severe symptomatic 8). Clinical evaluations performed morning, including blink frequency completeness, pre-corneal (NIBUT) pre-lens non-invasive break-up (PL-NIBUT), lipid interference patterns, meniscus height. Contact had a higher percentage incomplete blinks (37% vs. 19%, p < 0.001) reduced height compared to controls (0.24 0.08 0.28 0.10 mm, 0.014). PL-NIBUT was shorter than NIBUT (7.6 6.2 10.7 9.3 s. 0.002). Significant statistical differences between groups found (p 0.01) 0.05), recording times symptomatic. Long-term use silicone–hydrogel lenses can affect stability, production, adequate distribution through blinking. Ocular symptomology correlates stability both non-wearers.

Язык: Английский

Процитировано

0
Hydrophobic Silicon Quantum Dots for Potential Imaging of Tear Film Lipid Layer DOI Creative Commons
Sidra Sarwat, Fiona Stapleton, Mark Willcox

и другие.

Nanomaterials, Год журнала: 2025, Номер 15(7), С. 552 - 552

Опубликована: Апрель 4, 2025

The tear film, consisting of the aqueous and lipid layers, maintains homeostasis ocular surface; therefore, when disturbed, it can cause dry eye, which affects millions people worldwide. Understanding dynamics film layers is essential for developing efficient drug delivery systems eye disease. Quantum dots (QDs) offer potential real-time monitoring evaluating its dynamics. Hydrophilic silicon QDs (Si-QDs) have already been optimised to image layer film. This study was conducted optimise hydrophobic Si-QDs were synthesised in solution characterised by transmission electron microscope spectrofluorophotometry. fluorescence emission monitored vitro mixed with artificial tears. cytotoxicity assessed cultured human corneal epithelial cells using an MTT assay following 24 h exposure. 2.65 ± 0.35 nm size non-toxic at <16 µg/mL. emitted stable green 20 min but demonstrated aggregation higher concentrations. These findings highlight as a biomarker imaging layer. However, further research on surface functionalisation preclinical evaluations are recommended enhanced solubility biocompatibility surface.

Язык: Английский

Процитировано

0