Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3039 - 3053

Опубликована: Фев. 28, 2025

Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.

Язык: Английский

Parainflammation in the Ocular System: Considerations on the Underlying Mechanisms and Treatment of Dry Eye Disease

Ophthalmology and Therapy, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

The transition from regulated to dysregulated parainflammation is a new concept that needs be elucidated clarify the pathogenesis of dry eye disease (DED). This review summarizes recent evidence about mechanisms could lead parainflammation, proposing hypothesis correlate this process with progression chronic inflammation. A group European experts on DED participated in roundtable discuss role most common ocular diseases regard DED. Starting contents, narrative was conducted through PubMed search based main topics discussed, namely: dysfunctional tear film lipid and mucin alterations, cortisol. Parainflammation involved different pathologies characterized by involvement immune system complement factors. In DED, continuous persistent insults are responsible for qualitative quantitative alteration components film. addition, other contributing factors have recently been described, such as reduction cortisol synthesis corneal epithelial cells. altered condition leads excessive macrophage activity, releasing cytokines adhesion molecules, losing tissue homeostasis, possibly progressing Literature supports crucial its usefulness improving diagnosis treatment At same time, further investigations necessary better define functional including surface than

Язык: Английский

Preliminary Study on Total Glucoside of Peony (TGP) Administration in Organ-Specific Autoimmune Diseases at Prof. dr. R. D. Kandou Hospital, Indonesia

Asian Journal of Engineering Social and Health, Год журнала: 2024, Номер 3(3), С. 634 - 647

Опубликована: Март 5, 2024

Autoimmune diseases are a diverse group of conditions characterized by immune disturbances that cause aberrant B cell and T reactivity to normal constituents the host. These can involve essentially any organ system affect individuals age, with much greater prevalence among women. Although certain mechanisms unite these into single category, clinical manifestations autoimmune disease highly varied. This research is an original interventional study. It preliminary analytic observational. The design “the one pre-test – post-test design”. study was conducted at RSUP Prof. dr. R. D. Kandou over six-month period from July 2016 December 2016. included patients diagnosed Graves’ disease, Hashimoto’s aplastic anemia, who were based on their medical history, physical examination, diagnostic workups. also aimed evaluate improvement in symptoms within Aplastic Anemia group, tracking number complaints reported each week. Four study, receiving individualized basic therapy.

Язык: Английский